^18F-FDG PET/CTを用いた非小細胞肺癌縦隔リンパ節転移評価における偽陰性リンパ節と真陽性リンパ節の GLUT-1,SGLT-1,及びSGLT-2の発現の比較

医学専攻琉球大

Endobronchial electrocautery wire snare prior to wedge bronchoplastic lobectomy for central-type lung cancer: A case report

AbstractIntroductionOccasionally, it is difficult to design an appropriate treatment plan for central-type lung cancer. We present the usefulness of combined treatment with a bronchoscopic electrocautery wire snare prior to wedge bronchoplastic lobectomy for patients with central-type lung cancer.Presentation of caseA 64-year-old man, who was a long-term corticosteroid user, complicated with left obstructive pneumonia. Chest CT scan showed total atelectasis of the left lung due to obstruction of the left main bronchus by an endobronchial tumor, which protruded from the left lower lobe. He was diagnosed with squamous cell carcinoma of c-T3N0M0 Stage IIB. Endobronchial tumor resection of the left main bronchus was initially performed, which resulted in an improvement of the patient’s symptoms; the patient’s pulmonary function was evaluated and bronchial extension of the tumor was also observed. He subsequently underwent elective bronchoplastic left lower lobectomy and lymphadenectomy, with no recurrence 2 years after surgery.DiscussionA variety of therapeutic bronchoscopic intervention are available for the treatment of advanced central-type lung cancer. The effectiveness of endobronchial electrocautery using the snare wire has been reported for the treatment of respiratory tract tumors, which allowed planning of the following treatment procedure.ConclusionThe combination of a bronchoscopic electrocautery wire snare and bronchoplastic surgical procedure was useful for the treatment of central-type lung cancer such as in our case

Visualization of dietary docosahexaenoic acid in whole-body zebrafish using matrix-assisted laser desorption/ionization mass spectrometry imaging

Zebrafish models have been developed for several studies involving lipid metabolism and lipid-related diseases. In the present study, the migration of dietary docosahexaenoic acid (DHA) in whole-body zebrafish was estimated by stable-isotope tracer and matrix-assisted laser desorption/ionization mass spectrometry imaging.Administration of 1-13C-2,2-D2-labeled DHA ((+3)DHA) ethyl ester to male zebrafish was conducted to evaluate its accumulation, migration, and distribution in the body. The (+3)DHA content in the body of zebrafish after administering (+3)DHA for 10 and 15 d was significantly higher than that in the control group. (+3)DHA was observed as a constituent of phosphatidylcholine (PC) in the intestine of zebrafish that were administered (+3)DHA for 5 and 10 d. (+3)DHA-containing PC tended to accumulate in the intestines of zebrafish administered (+3)DHA for 1 d, indicating that recombination of (+3)DHA from ethyl ester to PC occurs quickly at intestine.After administration for 15 d, (+3)DHA-containing PC accumulated in the intestine, liver, and muscle of whole-body zebrafish. In contrast, (+3)DHA-containing PC was not detected in the brain.These results showed that dietary DHA is initially constructed into PC as a structural component of intestinal cell membranes and gradually migrates into peripheral tissues such as muscle.公開日: 2022-12-0

Giant pedunclated lipoma of the esophagus: A case report

Introduction: Although Esophageal lipoma is extremely rare and pathologically benign, surgical excision of the lipoma is recommended when symptomatic or uncertain biological behavior. In general, some of the esophageal lipoma has a stalk. The pedunclated non-invasive tumor can be removed by stalk ligation, which is either endoscopic or surgical approache. Therefore, the preoperative evaluation is essential. We herein present a case of a huge esophageal lipoma. Case report: A 82-year-old man, with a wet cough and dyspnea for 6 months, who had the huge mass that almost completely occupied the esophageal lumen, was referred to our institution for the treatment.We diagnosed the mass as non-invasive tumor that has a stalk at the close to the esophageal orifice, by the CT image using air injection into esophageal lumen. We performed excision of the pedunclated huge mobile mass by esophagotomy via right thoracic approach with use of endoloop. Pathological examination showed a lipoma. Conclusion: In conclusion, an adequate preoperative evaluation to identify the correct origin of the stalk is mandatory for a successful treatment. In order to do the adequate preoperative evaluation and successful surgery, our diagnostic method of CT image can be effective