Perinatal backgrounds of subjects (2).

<p>Perinatal backgrounds of subjects (2).</p

Relationship between PI and ‘Deciduitis’ by a mixed model analysis.

<p>Upper and lower panels indicate the marginal mean and SD values of the ponderal index (PI) and relative ratio of the marginal mean of PI. Red and blue dots indicate infants with and without ‘Deciduitis’. Error bars indicate standard deviations. ‘Deciduitis’ was a significant predictor of a small composition during the first 18 months of life by mixed model analysis (p = 0.035).</p

Perinatal backgrounds of subjects (1).

<p>Perinatal backgrounds of subjects (1).</p

Mixed model analysis of infantile PI during the first 18 months of life.

<p>Mixed model analysis of infantile PI during the first 18 months of life.</p

Representative pathological findings by HE staining in placentas.

<p>(A) ‘Accelerated villous maturation’; the yellow arrow indicates increases in the numbers of placental villi with the focal formation of tight adherent villous clusters with syncytial knots. (B) ‘Decidual vasculopathy’; the yellow arrow indicates the thrombus in decidual vessels. (C) ‘Thrombosis or Intramural fibrin deposition’; the yellow arrow indicates the fibrin cushion in the walls of stem villous vessels. (D) ‘Avascular villi’: the yellow arrow indicates a villi with hyalinized stroma which is devoid of vessels. (E) ‘Delayed villous maturation’; the yellow arrow indicates increases in the size of distal villi, increases in the numbers of stromal cells, and interstitial fluid uniformly distributed throughout the villous stroma. (F) ‘Maternal inflammatory response’; the yellow arrow indicates the infiltration of neutrophils in to the chorionic plate. (G) ‘Fetal inflammatory response’; the yellow arrow indicates the infiltration of neutrophils in to the umbilical vessel. (H) ‘VUE’; the yellow arrow indicates lymphohistiocytic inflammation predominantly in the stroma of terminal villi. (I) ‘Deciduitis’; the yellow arrow indicates the infiltration of lymphocytes and macrophages.</p

Relationship between body weight and ‘Maternal vascular malperfusion’ by a mixed model analysis.

<p>Upper and lower panels indicate the marginal mean and SD values of body weights and the relative ratio of the marginal mean of body weights. Red and blue dots indicate infants with and without ‘Maternal vascular malperfusion’, respectively. Error bars indicate standard deviations. ‘Maternal vascular malperfusion’ was a significant predictor of a light body weight in the first 18 months of life by mixed model analysis (p = 0.020).</p

Mixed model analysis of infantile body weight during the first 18 months of life.

<p>Mixed model analysis of infantile body weight during the first 18 months of life.</p

Relationship between body weight and ‘Accelerated villous maturation’ by a mixed model analysis.

<p>Upper and panels indicate the marginal mean and SD values of body weights and the relative ratio of the marginal mean of body weights. Red and blue dots indicate infants with and without ‘Accelerated villous maturation’, respectively. Error bars indicate standard deviations. ‘Accelerated villous maturation’ was a significant predictor of a light body weight in the first 18 months of life by mixed model analysis (p<0.001).</p

Placental measurement of the subjects in 258 placentas investigated.

<p>Placental measurement of the subjects in 258 placentas investigated.</p

Detection of pathological findings in 258 placentas investigated.

<p>Detection of pathological findings in 258 placentas investigated.</p