Letter to the editor concerning “Liver transplantation for metastatic wild-type gastrointestinal stromal tumor in the era of molecular targeted therapies: Report of a first case"

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Does Explainable AI Have Moral Value?

Explainable AI (XAI) aims to bridge the gap between complex algorithmic systems and human stakeholders. Current discourse often examines XAI in isolation as either a technological tool, user interface, or policy mechanism. This paper proposes a unifying ethical framework grounded in moral duties and the concept of reciprocity. We argue that XAI should be appreciated not merely as a right, but as part of our moral duties that helps sustain a reciprocal relationship between humans affected by AI systems. This is because, we argue, explanations help sustain constitutive symmetry and agency in AI-led decision-making processes. We then assess leading XAI communities and reveal gaps between the ideal of reciprocity and practical feasibility. Machine learning offers useful techniques but overlooks evaluation and adoption challenges. Human-computer interaction provides preliminary insights but oversimplifies organizational contexts. Policies espouse accountability but lack technical nuance. Synthesizing these views exposes barriers to implementable, ethical XAI. Still, positioning XAI as a moral duty transcends rights-based discourse to capture a more robust and complete moral picture. This paper provides an accessible, detailed analysis elucidating the moral value of explainability.Comment: Preprint. Work in progress. Accepted at the workshop MP2 at NeurIPS 2023, 15 December 2023, New Orleans, U

SDHA Germline Mutations in SDH-Deficient GISTs: A Current Update

Loss of function of the succinate dehydrogenase complex characterizes 20-40% of all KIT/PDGFRA-negative GIST. Approximately half of SDH-deficient GIST patients lack SDHx mutations and are caused by a hypermethylation of the SDHC promoter, which causes the repression of SDHC transcription and depletion of SDHC protein levels through a mechanism described as epimutation. The remaining 50% of SDH-deficient GISTs have mutations in one of the SDH subunits and SDHA mutations are the most common (30%), with consequent loss of SDHA and SDHB protein expression immunohistochemically. SDHB, SDHC, and SDHD mutations in GIST occur in only 20-30% of cases and most of these SDH mutations are germline. More recently, germline mutations in SDHA have also been described in several patients with loss of function of the SDH complex. SDHA-mutant patients usually carry two mutational events at the SDHA locus, either the loss of the wild type allele or a second somatic event in compound heterozygosis. This review provides an overview of all data in the literature regarding SDHA-mutated GIST, especially focusing on the prevalence of germline mutations in SDH-deficient GIST populations who harbor SDHA somatic mutations, and offers a view towards understanding the importance of genetic counselling for SDHA-variant carriers and relatives

Thermal Noise-Boosting Effects in Hot-Wire-Based Micro Sensors

This article proposes an original approach aimed at modelling the noise density in sensors based on a single hot wire or pairs of thermally coupled wires. The model consists in an original combination of a previous electrothermal model of the wire with well-established assumptions on the thermal noise in conductors that carry moderate current densities. A simple method for estimating the model parameters with simple impedance spectroscopy is suggested. The predicted power spectral densities of the wire thermal noise differ from the result of previously presented analytical models, stimulating further experimental studies. The effects of the electrothermal feedback of both hot wires and hot-wire pairs on flicker noise is also intrinsically covered by the proposed approach

Extinction and paleoecology of the Late Pleistocene cave bear from northeastern Italy: radiocarbon and stable isotope evidence

We present here the chronometric, isotopic and taphonomic evidence of cave bear from three Palaeolithic sites in north-eastern Italy: Paina, Trene and Buso doppio del Broion (Berici Hills - Vicenza). Two direct radiocarbon dates yielded an age around 24 ka BP, which make these remains the latest known representatives of the species in Europe and confirmed that demise of cave bear falls during the LGM. The carbon and nitrogen isotopic values of bone collagen do not show any marked ecological change since 33 ka BP, suggesting an essential vegetarian diet. Several bear bones preserved traces of human modification such as cut marks, which en-ables a reconstruction of the main steps of butchering process

Experimental and archaeological data for the identification of projectile impact marks on small-sized mammals

The role of small game in prehistoric hunter-gatherer economy is a highly debated topic. Despite the general assumption that this practice was uneconomic, several studies have underlined the relevance of the circumstance of capture – in terms of hunting strategies and technology – in the evaluation of the actual role of small mammals in human foraging efficiency. Since very few studies have focused on the recognition of bone hunting lesions, in a previous work we explored the potential of 3D microscopy in distinguishing projectile impact marks from other taphonomic marks, developing a widely-applicable diagnostic framework based on experimental data and focused on Late Epigravettian projectiles. Even though we confirmed the validity of the method on zooarchaeological remains of large-sized mammals, the reliability of the experimental record in relation to smaller animals needed more testing and verification. In this report we thus present the data acquired through a new ballistic experiment on small mammals and compare the results to those previously obtained on medium-sized animals, in order to bolster the diagnostic criteria useful in bone lesion identification with specific reference to small game. We also present the application of this renewed methodology to an archaeological context dated to the Late Glacial and located in the eastern Italian Alps

18F-FDG-PET/CT imaging in cardiac tumors: illustrative clinical cases and review of the literature.

Cardiac tumors are a very rare condition. Mostly, they are benign tumors (75%), with myxomas being the most frequent. The remaining 25% are malignant; either primary malignant sarcoma or secondary metastases. Given the small number of cases reported and the lack of prospective and randomized clinical trials, the level of evidence for the optimal multimodal treatment of primary cardiac sarcomas is very low and the optimal imaging diagnostic workup is not well established. In particular, 18F-FDG-PET/CT is not yet included in routine diagnosis of cardiac masses. Here, we report four illustrative clinical cases and a review of the literature on the current available data on the role of 18F-fluorodeoxyglucose PET/CT imaging in cardiac tumors

Successful selective arterial embolizations for bone metastases in renal cell carcinoma integrated with systemic therapies: A case report

the initial cytoreductive nephrectomy to 3 successive lines of medical treatment (sunitinib, everolimus, and sorafenib) and multiple locoregional treatments (spinal surgery, radiation therapy, and selective arterial embolization), resulting in a surprisingly long survival of over 75 months. In the era of target therapy, integration strategies, including additional locoregional treatment to medical therapy, are essential to optimize the clinical benefit, to maximize treatment duration overcoming focal progressive disease, and to improve the quality of life. In this context, we would highlight that selective transcatheter embolization of bone metastases from renal cell carcinoma should be considered as an effective and safe option in the palliative setting for patients with bone metastasis, especially for pain relief

Thoracic myopericytoma in an older adult, rare but possible: A case report

Myopericytoma is a rare tumor generally arising from skin and soft tissues of extremities, trunk, head, and neck regions, rarely from visceral sites. An intrathoracic visceral localization may carry a broad differential diagnosis including primary lung, pleura and chest wall lesions, or metastatic lesions. To date, any radiological features have been recognized and diagnosis of myopericytoma with intrathoracic localization remains still challenging. Here, we describe the case of a subpleural lesion incidentally diagnosed in an older adult affected by gastric cancer. Radiological features did not allow a differential diagnosis between a benign lesion, a primary tumor, or a metastasis. After resection, the histological examination showed histopathological features congruent with the diagnosis of myopericytoma. This unusual presentation reflects the need to share clinical, radiological, and histopathological data about this uncommon but frequently misdiagnosed disease