Regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles by reusable AlCl₃ immobilized on ϒ-Aɭ₂O₃

Abstract: There is rapidly growing interest in the synthesis and use of substituted 1,2,3- triazoles. We report an easy and interesting procedure that demonstrates the effectiveness of surface-modified c-Al2O3, which is reusable, efficient, catalytic, safe, and environmentally acceptable for the regioselective synthesis of 1,5-disubstituted-1,2,3- triazoles via [3þ2] cycloaddition of phenyl and benzyl azides with a series of aryl nitroolefins in good yields. No adverse effect on substituents such as nitro, cyano, hydroxy, ether linkage, and halogens was observed. The catalyst could easily be recycled and was reused for nine runs without losing its activity

Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles by Reusable AlCl₃ Immobilized on γ-Al₂O₃

<div><p></p><p>There is rapidly growing interest in the synthesis and use of substituted 1,2,3-triazoles. We report an easy and interesting procedure that demonstrates the effectiveness of surface-modified γ-Al₂O₃, which is reusable, efficient, catalytic, safe, and environmentally acceptable for the regioselective synthesis of 1,5-disubstituted-1,2,3-triazoles via [3 + 2] cycloaddition of phenyl and benzyl azides with a series of aryl nitroolefins in good yields. No adverse effect on substituents such as nitro, cyano, hydroxy, ether linkage, and halogens was observed. The catalyst could easily be recycled and was reused for nine runs without losing its activity.</p></div

Novel synthesis of 1,5-disubstituted-1,2,3-triazolines catalysed by Zepto™ magnetic microspheres under the influence of rotating magnetic field

The novel reactor has been designed to perform chemical reactions under the influence of magnetic field generated by alternating magnetic poles as a function of time and successfully employed the system to synthesize a series of 1,5-disubstituted-1,2,3-triazolines via the regioselective [3+2] cycloaddition reactions between alkyl/aryl azides and nitro-olefins catalysed by Zepto™ (para magnetic ultra-blue carboxy functionalized) microspheres (bead diameter 2.5 μm). All the reactions went smoothly without any adverse effect on nitro, cyano, thienyl, hydroxy, halogens and ether functions at 25±2°C, to afford 82-99% pure products at magnetic field and exposure time of 18.99 mT and 180-240 min. The influence of magnetic force exerted on the magnetic materials was found to enhance the catalytic activity of microspheres. The catalyst could easily be separated by simple centrifugation which could be reused for at least 15 runs with no loss in activity.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author