Dynamic response of the protein biosynthesis pathway following heat shock

<p><b>Copyright information:</b></p><p>Taken from "Dynamic resolution of functionally related gene sets in response to acute heat stress"</p><p>http://www.biomedcentral.com/1471-2199/8/46</p><p>BMC Molecular Biology 2007;8():46-46.</p><p>Published online 5 Jun 2007</p><p>PMCID:PMC1904231.</p><p></p> (A) Overview depiction of the dynamic response of the protein biosynthesis pathway gene set following heat shock over 24 hours. Data is represented as for Figure 5. (B) Dotplot diagram showing the upregulation in expression of the same gene set after 1 hour post-heat shock

Stress response gene set is bi-directional during response to heat shock in C2C12 cell

<p><b>Copyright information:</b></p><p>Taken from "Dynamic resolution of functionally related gene sets in response to acute heat stress"</p><p>http://www.biomedcentral.com/1471-2199/8/46</p><p>BMC Molecular Biology 2007;8():46-46.</p><p>Published online 5 Jun 2007</p><p>PMCID:PMC1904231.</p><p></p> Distribution in stress response-related gene sets during response to heat shock of C2C12 myotubes. All probes representing the stress response gene set are presented as an expression ratio of time against time . Frequency () represents the number of probes in each gene set with the corresponding expression ratio (). The statistical significance of the mean expression variance ratio for the gene set relative to all other probesets is indicated. Variance between 0 – 8 hours (A) and 8 – 24 hours (B) post-heat shock are depicted in the figure. Dotplot representations of GSEA as a function of C2C12 response to heat shock is also presented. The of each plot represents expression levels at time , and the represents expression at time . Each dot represents a single probe on the GeneChip. The total probe set (grey dots) and the specific gene set (blue dots) are presented on the same plot to give direct perspective of gene set regulation. The stress response probe set is represented by 122 gene probes, previously annotated as related to the stress response. The list is attached in Additional file

Additional file 1: of Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy

Table S1 Definition of adapted ACR JIA response. Table S2 Genes with ≥3-fold differential expression between patients with SJIA and healthy controls, prior to canakinumab treatment. Table S3 List of independent ethics committees or institutional review boards (trial 1). Table S4 List of independent ethics committees or institutional review boards (trial 2). (DOCX 53 kb