Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries

NRC publication: Ye

Combinatorial synthesis of the peptidomimetic inhibitors of HIV 1 protease

498-506A cobalt-catalyzed combinatorial synthesis of various β-phenylisoserinederivatives is described. This methodology is applied to a one-pot synthesis of pyrrolidine- containing α-hydroxyamidecore structure β-phenylisoserine-valinedipeptide isostere and α-acetyl- or α-hydroxyethyl- β -amino acid derivatives