Synthesis and antihistaminic activity of 3H-benzo [4,5] thieno [2,3-d][1,2,3] triazin-4-ones

AbstractIn the present study the antihistaminic activity of tricyclic benzothieno 1,2,3-triazine derivatives namely CP-3 (3-(phenyl)-5,6,7,8-tetrahydro,3H-benzo[4,5] thieno [2,3-d][1,2,3] triazin-4-one), CP-5 (3-(3-methyl phenyl)-5,6,7,8-tetrahydro,3H-benzo[4,5] thieno [2,3-d][1,2,3] triazin-4-one) and CP-8 (3-(4-chloro phenyl)-5,6,7,8-tetrahydro,3H-benzo[4,5] thieno [2,3-d][1,2,3] triazin-4-one) were evaluated using in vitro (isolated guinea pig ileum) and in vivo (bronchodilator activity in guinea pigs) models and the sedative potential of the test compounds were evaluated using actophotometer in mice. In in vitro antihistaminic study, the CP-3, CP-5, CP-8 and chlorpheniramine maleate (CPM) have shown a rightward shift in concentration response curve (CRC) of histamine with a change in EC50 values of histamine in all the four tissue preparations. The slope obtained in the schild plot indicated that CP-5, CP-8 and CPM were competitive in nature for H1-receptors. However, CP-3 has shown non-competitive antagonism. In in vivo antihistaminic study, the CP-3, CP-5, CP-8 and CPM have shown mean increase in exposition time against histamine challenge compared to control group (p<0.001). All the test drugs (10mg/kg) and CPM (2mg/kg) have offered a significant (p<0.001) protection against preconvulsive dyspnoea (PCD) compared to control. In conclusion, all the test drugs have shown very good antihistaminic activity and the test drugs have very little sedative action compared to CPM

How can Japan help create a sustainable hydrogen society in Asia?

Japan has adopted several policies that signal its intent to rely on hydrogen to achieve net-zero climate goals. However, many of those same policies are unclear about its support for a transition to green hydrogen. Relying on gray and blue hydrogen without a transition to green hydrogen will harm the climate. It will also result in several other lost international cooperation and local socioeconomic benefits. This paper argues that greater clarity about the transition to green hydrogen will help strengthen the alignment with Japan's international climate strategy and local revitalization policies. It then proposes a set of recommendations that can clarify its support for transitioning to green hydrogen in national policies as well as international climate and local revitalization strategies

Quantifying the Climate Co-Benefits of Hybrid Renewable Power Generation in Indonesia: A Multi-Regional and Technological Assessment

Quantifying the co-benefits of renewable energy investments can aid policymakers in identifying technologies capable of generating significant social, economic, and environmental benefits to effectively offset mitigation costs. Although there has been a growing body of work evaluating co-benefits, few studies have compared the potential co-benefits of several technologies across different regions in key countries. This study fills this gap by formulating a new modeling structure to assess the environmental–health–economic co-benefits of hybrid renewable energy systems (HRESs) in different parts of Indonesia. The proposed model is unique in that it incorporates various techno-economic activities to assess air quality, health, and economic benefits and then presents results as part of a cost–benefit analysis. From the intervention scenario, the modeling results show that installing 0.5 GW grid-connected solar PV, 100 MW of wind turbines, and a 100 MW biomass generator to cover a total of 1.64 million residential load units in the Bali province can avoid GHGs, PM2.5, disability-adjusted life years (DALYs), and provide health savings of 1.73 Mt/y, 289.02 t/y, 1648, and 6.16 million USD/y, respectively. In addition, it shows that the payback period is enhanced by one year, while the net present value is increased by 28%. In Jakarta, a 3 GW solar PV plant and a 100 MW biomass generator that supply 5.8 million residential load units can deliver 32,490 averted DALYs and 652.81 million USD/y of health care savings. Nationally, the contribution of renewable energy to the electricity supply mix could grow from the 2020 baseline of 18.85% to 26.93%, reducing dependence on oil and coal contribution by 5.32%