Brain regions with negative correlation between grey matter volume and the number of optic neuritis attacks.

<p>P, P value corrected for multiple comparisons at cluster level; GM, grey matter.</p

Brain perfusion positive correlation with the number of optic neuritis attacks in RNMO patients.

<p>The same slices as shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066271#pone-0066271-g001" target="_blank">Figure 1</a>, presenting the perfusion positive correlation statistical parametric map, which was found in an extensive brain area mainly located in the white matter. Note that perfusion changes included periventricular areas. Statistical parametric map was thresholded at p value <0.01 (p value <0.05 corrected for multiple comparisons at the cluster level).</p

Demographic and clinical characteristics of patients with relapsing neuromyelitis optica (n = 15).

<p>Data shown as median and range (minimum, maximum). EDSS, Kurtzke Expanded Disability Status Scale <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066271#pone.0066271-Kurtzke1" target="_blank">[24]</a>; ON, optic neuritis; LETM, longitudinally extensive transverse myelitis; NMO-IgG, antiaquaporin-4 autoantibody;</p>*<p>Last attack MRI/SPECT time interval.</p

Multimodal negative correlation pattern with the number of optic neuritis attacks in RNMO patients.

<p>Axial, sagittal and coronal selected slices at four brain levels (levels shown as white lines in the figures on the right side), presenting overlays of negative correlation statistical parametric maps of white matter volume (in green), grey matter volume (in blue) and perfusion (in pink) on a T1-weighted high resolution MRI template. Decreases of tissue volumes and perfusion with the increase of the number of optic neuritis attacks comprised extensive brain regions, including important components of the visual system such as posterior thalamic radiations (white matter volume), middle and superior temporal gyri (grey matter volume) and the primary visual area (perfusion). Also note that tissue volume decreases included regions close to periaqueductal areas. Statistical parametric maps were thresholded at p value <0.01 (p value <0.05 corrected for multiple comparisons at the cluster level).</p

Brain regions with positive correlation between perfusion and the number of optic neuritis attacks.

<p>P, P value corrected for multiple comparisons at cluster level; DWM, deep white matter; SWM, superficially located white matter; GM, grey matter.</p

Brain regions with negative correlation between white matter volume and the number of optic neuritis attacks.

<p>P, P value corrected for multiple comparisons at cluster level; DWM, deep white matter; SWM, superficially located white matter.</p