Sensorimotor Behavioral Tests for Use in a Juvenile Rat Model of Traumatic Brain Injury: Assessment of Sex Differences

Modeling juvenile traumatic brain injury (TBI) in rodents presents several unique challenges compared to adult TBI, one of which is selecting appropriate sensorimotor behavioral tasks that enable the assessment of the extent of injury and recovery over time in developing animals. To address this challenge, we performed a comparison of common sensorimotor tests in Long-Evans rats of various sizes and developmental stages (postnatal days 16–45, 35–190 g). Tests were compared and selected for their developmental appropriateness, scalability for growth, pre-training requirements, and throughput capability. Sex differences in response to TBI were also assessed. Grid walk, automated gait analysis, rotarod, beam walk, spontaneous forelimb elevation test, and measurement of motor activity using the force-plate actometer were evaluated. Grid walk, gait analysis, and rotarod failed to meet one or more of the evaluation criteria. Beam walk, spontaneous forelimb elevation test, and measurement of motor activity using the force-plate actometer satisfied all criteria and were capable of detecting motor abnormalities in rats subjected to controlled cortical impact on postnatal day 17. No sex differences were detected in the acute effects of TBI or functional recovery during the 28 days after injury using these tests. This demonstrates the utility of these tests for the evaluation of sensorimotor function in studies using rat models of pediatric TBI, and suggest that pre-pubertal males and females respond similarly to TBI with respect to sensorimotor outcomes

Adolescents Who Play and Spend Money in Simulated Gambling Games Are at Heightened Risk of Gambling Problems

Simulated gambling, such as playing a virtual slot machine for points rather than money, is increasingly part of the online gaming experience for youth. This study aimed to examine (1) if youth participation in simulated gambling games is associated with participation in monetary gambling; (2) if youth participation in simulated gambling games is associated with increased risk of problematic gambling when controlling for breadth of monetary gambling (i.e., number of gambling forms); and (3) if monetary expenditure and time spent playing simulated gambling games increase the risk of problematic gambling. Two samples of Australians aged 12–17 years were recruited—826 respondents through an online panel aggregator (mean age 14.1 years) and 843 respondents through advertising (mean age 14.6 years). Aim 1 was addressed using chi-square and correlation analyses. Linear multiple regression analyses were conducted to address Aims 2 and 3. The findings in both samples supported the study’s hypotheses—that (1) youth who play simulated gambling games are more likely to participate in monetary gambling, and that (2) participation and (3) time and money expenditure on simulated gambling are positively and independently associated with risk of problematic gambling when controlling for the number of monetary gambling forms, impulsivity, age and gender. To better protect young people, simulated gambling should, at minimum, emulate the consumer protection measures required for online gambling

Identifying the Tuskegee Syphilis Study: implications of results from recall and recognition questions

<p>Abstract</p> <p>Background</p> <p>This analysis assessed whether Blacks, Whites and Puerto-Rican (PR) Hispanics differed in their ability to identify the Tuskegee Syphilis Study (TSS) via open-ended questions following lead-in recognition and recall questions.</p> <p>Methods</p> <p>The Tuskegee Legacy Project (TLP) Questionnaire was administered via a Random-Digit Dial (RDD) telephone survey to a stratified random sample of Black, White and PR Hispanic adults in three U.S. cities.</p> <p>Results</p> <p>The TLP Questionnaire was administered to 1,162 adults (356 African-Americans, 313 PR Hispanics, and 493 non-Hispanic Whites) in San Juan, PR, Baltimore, MD and New York City, NY. Recall question data revealed: 1) that 89% or more of Blacks, Whites, and PR Hispanics were not able to name or definitely identify the Tuskegee Syphilis Study by giving study attributes; and, 2) that Blacks were the most likely to provide an open-ended answer that identified the Tuskegee Syphilis Study as compared to Whites and PR Hispanics (11.5% vs 6.3% vs 2.9%, respectively) (p ≤ 0.002). Even when probed by a recognition question, only a minority of each racial/ethnic group (37.1%, 26.9%, and 8.6%, for Blacks, Whites and PR Hispanics, respectively) was able to clearly identify the TSS (p < 0.001).</p> <p>Conclusions</p> <p>The two major implications of these findings for health disparity researchers are 1) that it is unlikely that detailed knowledge of the Tuskegee Syphilis Study has any current widespread influence on the willingness of minorities to participate in biomedical research, and 2) that caution should be applied before assuming that what community leaders 'know and are aware of' is equally 'well known' within their community constituencies.</p

Loot box purchasing is linked to problem gambling in adolescents when controlling for monetary gambling participation

BACKGROUND AND AIMS: Purchasing loot boxes in digital games is akin to gambling as it involves risking money for a chance-based reward of uncertain value. Research has linked buying loot boxes to problem gambling amongst adolescents, but has not examined co-occurring gambling participation. This study examined links between loot box purchasing and problem gambling amongst adolescents while controlling for monetary gambling participation. METHODS: Two survey samples of Australians aged 12–17 years were recruited through advertisements (n = 843) and online panels (n = 826). They included n = 421 and n = 128 adolescents, respectively, who met criteria for problem gambling. RESULTS: Past-month loot box purchasing was significantly related to gambling problems in bivariate analyses. When including age, gender and past-month monetary gambling, loot box purchases were still associated with at-risk and problem gambling in both samples. As expected, these other predictors attenuated the predictive value of recent loot box purchases in relation to gambling problems. The odds-ratios, nevertheless, were still in the predicted direction and remained significant. When controlling for monetary gambling, age and gender, recent loot box purchasing increased the odds of problem gambling 3.7 to 6.0 times, and at-risk gambling 2.8 to 4.3 times. DISCUSSION AND CONCLUSIONS: While causal relationships between loot box purchasing and problem gambling remain unclear, the results indicate that loot boxes disproportionately attract adolescents experiencing gambling problems, adding to the financial stress already caused by gambling. Consumer protection measures, youth and parental education, and age restrictions on loot box games are needed to protect young people

Electric Field Effects on Fiber Alignment Using an Auxiliary Electrode during Electrospinning

This viewgraph presentation reviews auxiliary and electric field effects on fiber alignment during the process of electrospinning. The contents include: 1) Electrospinning Overview; 2) Experimental Set-up; 3) Jet Exit; 4) Auxiliary Electrode Effects; 5) Electrospinning High Speed Video; 6) Effect of Auxiliary Electrode Position; 7) Micro & Nano Fibers Produced; 8) Micro and Nano Fibrous Mats; 9) Field Effect on Fiber Distribution; 10) Modeling; 11) Calculated trajectories: 5, 10, 15 & 20cm electrode spacing; 12) Off Axis Auxiliary Electrode; 13) Field Strength Effects; and 14) Potential Applications

Portable Unit for Metabolic Analysis

The Portable Unit for Metabolic Analysis measures human metabolic function. The compact invention attaches to the face of a subject and it is able to record highly time-resolved measurements of air temperature and pressure, flow rates during inhalation and exhalation, and oxygen and carbon dioxide partial pressure. The device is capable of `breath-by-breath` analysis and `within-breath` analysis at high temporal resolution

Choral Classics Concert

Sololists: Ivin Bellamy, bass, will perform the Benedictus. He is a junior who participates in basketball, volleyball, track and field, orchestra and chorus. He plans to at-tend the University of North Carolina majoring in music. Kiyah Bracy, soprano, performs as soloist on the Kyrie. She is a senior who par-ticipates in theatre and chorus. She plans on attending Georgia State University with a major in human biology, aspiring to be a pediatric surgeon. Taniyah Colter, soprano, sings as soloist on the Gloria. She is a senior and is the vice president of the choral program. She hopes to attend college to major in psychology and minor in vocal music. Her goal is to become a psychologist. Alona Fransis, soprano, is heard today as soloist on the piece Benedictus. She is a junior who participates in the marching band, and chorus. In the future, she plans to attend Regent University and major in criminal justice. Christopher Freeman, bass, is heard as soloist on the Gloria. He is a senior who participates in volleyball, chorus, enjoys writing and plans to attend Norfolk State University for psychology. Markle Juste, tenor, will perform the Benedictus. Markle is a senior who partici-pates in the theatre program and chorus. After high school, he would like to be a merchant seaman. Sidney Mapp, soprano, will solo on the Gloria. As a sophomore, she is in volley-ball, chorus, and enjoys reading. She plans to attend the University of Virginia to become a nurse. Savion White, bass, is a soloist on the Agnus Dei. Savion is a senior who partici-pates in volleyball and the Teens With a Purpose poetry club. After high school, he hopes to attend The American Musical and Dramatic Academy for music performance and production. Jordan Wright, soprano, will perform as soloist on the Agnus Dei. Jordan is a junior who participates in chorus and enjoys drawing and writing. She plans is to attend Old Dominion University and major in graphic design