A study of effects of disparity between support expectation and receipt in dyadic relationship(Department of Sciences for Biospheric Coexistence)

博士学位論文要

Acclimation of Chlamydomonas to changing carbon availability

Aquatic organisms, including Chlamydomonas reinhardtii, are faced with a variable supply of dissolved inorganic carbon (Ci). Accordingly, C. reinhardtii has the ability to acclimate to the changing Ci supply through a variety of responses, including induction of a CO2 concentrating mechanism (CCM) when Ci is limiting. The CCM uses active Ci uptake to accumulate a high internal concentration of bicarbonate, which is dehydrated by a specific thylakoid carbonic anhydrase to supply CO2, the substrate used in photosynthesis. In addition to the changes demonstrably related to the function of the CCM, C. reinhardtii exhibits several other acclimation responses to limiting Ci, such as changes in cellular organization and induction or upregulation of several genes. A key area currently under investigation is how C. reinhardtii cells recognize the change in Ci or CO2 concentration, and transduce that signal into needed gene expression changes. Mutational analyses are proving very useful for learning more about the CCM and about the acclimation response to changes in Ci availability. Cloning of the gene disrupted in cia5, a mutant apparently unable to acclimate to limiting Ci, has opened opportunities for more rapid progress in understanding the signal transduction pathway. The Cia5 gene appears to encode a transcription factor that may control, either directly or indirectly, much of the gene expression responses to limiting Ci in C. reinhardtii. Several additional new mutants with potential defects in the signal transduction pathway have been isolated, including three new alleles of cia5

Regulation of endothelin-1 production in cultured rat mesangial cells

Regulation of endothelin-1 production in cultured rat mesangial cells. We investigated the regulatory mechanisms of endothelin (ET)-1 production in cultured rat mesangial cells (MC), with a special focus on the roles of protein kinase A (PKA)- and protein kinase C (PKC)-mediated signaling systems. Vasoactive agents and growth promoting factors, including platelet-derived growth factor, vasopressin and thrombin, which act through receptors coupled to the phospholipase C-mediated signaling system, as well as phorbol ester and fetal calf serum stimulated ET-1 production. This effect was attenuated in PKC-depleted or H-7 (a PKC inhibitor) treated MC. On the other hand, an increase in intracellular cyclic AMP by forskolin or β-adrenergic agonist, isoproterenol, which act as anti-mitogenic agents, inhibited serum-stimulated ET-1 production. In addition this effect was mimicked by the addition of 8-bromo-cyclic AMP to the medium. The effect of isoproterenol was abolished by propranolol. H-8, a PKA inhibitor, attenuated the inhibitory effect of forskolin. These findings suggest that ET-1 production in MC is regulated by interaction of both positive and negative signals mediated by PKC- and PKA-dependent mechanisms

Japón: servicio universal, alta definición y movilidad

“Diversidad cultural y audiovisual: buenas prácticas e indicadores” (ref. CSO2011-26241), pertenece al Plan Nacional I+D+i del Ministerio de Economía y Competitividad de España. “Convergencia digital: el futuro de las tecnologías y los contenidos de la información y la comunicación”, está financiado por la Comisión de Apoyo al Personal de Educación Superior (CAPES), de Brasil, y cuenta con la participación de investigadores de las universidades Carlos III de Madrid, do Vale do Rio dos Sinos y Federal de Sergipe

Phase diagram of the pairing symmetry in two-dimensional strong-coupling superconductors

Two-dimensional Eliashberg equations have been solved by use of a mixed interaction with $s$- and $d$-channels. It is discussed what kind of pairing symmetry of the superconducting state can be realized when the channel mixing parameters and the band-filling are varied. By changing the mixing parameters and varying the chemical potential $\mu$ between zero- and half-filling, the pairing symmetry is determined and summarized into a phase diagram of the symmetry. It is revealed that there is an effective threshold in $\mu$ for the appearance of the d-wave superconductivity regardless of the strength of the $d$-channel interaction. It is also shown that, although the s-wave superconductivity can occur for any value of $\mu$ if the $s$-channel interaction is mixed sufficiently, the d-wave superconductivity has the advantage of achieving a high $T_{c}$ over the s-wave one, once it occurs.Comment: 11 pages, LaTe