小児肺高血圧症における肺組織ヘムオキシゲナーゼ1発現の特徴

取得学位 : 博士（医学）, 学位授与番号 : 医博甲第1648号, 学位授与年月日 : 平成16年9月30日, 学位授与大学 : 金沢大

Cystatin C in children with malignancies

Several factors besides renal function influence serum cystatin C (CysC) levels. The present study evaluates the value of serum CysC and the equation for CysC based estimated glomerular filtration rate (CysC-eGFR) for Japanese children with malignancies.We collected information at 36 time points from 13 patients aged ≤ 17 years with malignancies. We assessed tumor activity, cell recovery phase after chemotherapy, neutropenia phase, inflammation response and medication with granulocyte-colony stimulating factor, steroid, and levothyroxine as risk factors associated with serum CysC levels. Although no 24-h creatinine clearance (CCr) data collected at 36 time points indicated renal dysfunction, serum CysC levels were above and below the reference values at four and five time points, respectively. The frequency of elevated serum CysC levels was higher in patients without therapy or with stable or progressive disease than among those with a complete or partial response (p = 0.0046). The correlation coefficient between CCr and CysC-eGFR was 0.355 (p = 0.054), but this improved to 0.663 (p = 0.0010) when restricted to patients with a complete or partial response. Levels of serum CysC might become elevated regardless of renal function, and CysC-eGFR might become unpredictable during the active phase of tumors

X-Ray Single-Grating Interferometry for Wavefront Measurement and Correction of Hard X-Ray Nanofocusing Mirrors

X-ray single-grating interferometry was applied to conduct accurate wavefront corrections for hard X-ray nanofocusing mirrors. Systematic errors in the interferometer, originating from a grating, a detector, and alignment errors of the components, were carefully examined. Based on the measured wavefront errors, the mirror shapes were directly corrected using a differential deposition technique. The corrected X-ray focusing mirrors with a numerical aperture of 0.01 attained two-dimensionally diffraction-limited performance. The results of the correction indicate that the uncertainty of the wavefront measurement was less than λ/72 in root-mean-square value.Yamada, J.; Inoue, T.; Nakamura, N.; Kameshima, T.; Yamauchi, K.; Matsuyama, S.; Yabashi, M. X-Ray Single-Grating Interferometry for Wavefront Measurement and Correction of Hard X-Ray Nanofocusing Mirrors. Sensors 2020, 20, 7356. https://doi.org/10.3390/s20247356

Magnetic phase boundary of BaVS3 clarified with high-pressure mu+SR

The magnetic nature of the quasi-one-dimensional BaVS3 has been studied as a function of temperature down to 0.25 K and pressure up to 1.97 GPa on a powder sample using the positive muon spin rotation and relaxation (mu(+) SR) technique. At ambient pressure, BaVS3 enters an incommensurate antiferromagnetic ordered state below the Neel temperature (T-N)31 K. T-N is almost constant as the pressure (p) increases from ambient pressure to 1.4 GPa, then T-N decreases rapidly for p > 1.4 GPa, and finally disappears at p similar to 1.8 GPa, above which a metallic phase is stabilized. Hence, T-N is found to be equivalent to the pressure-induced metal-insulator transition temperature (T-MI) at p > 1.4 GPa

The Practical Research of the Support for the Preschooler from Abroad: To Construct Early Childhood Education for Promote Communication

本研究では，近年増加傾向にある外国籍幼児の支援に関する実践的研究を行った。外国籍の幼児は，母語しか話せない場合がほとんどであり，制度としても就学児のような手厚いサポートが受けられない。そのため，保育における意思疎通の難しさが問題となるため，コミュニケーションの広がりを目指した保育の構築を検討した。エピソード収集及びカンファレンスを行うことで対象児の変容と支援の内容を把握することを通して，外国籍幼児のコミュニケーションを広げるためには，以下の四点が有効であることが示唆された。①遊びを通して幼児同士が通じ合える経験の重要性，②双方の言葉を用いたアプローチの有効性，③保育者の意識変容の重要性，④保護者と保育者の隙間を埋めることの必要性。This study aimed to support the preschoolers from abroad. Most of them speak an only mother tongue. There is no institutional support for them. Accordingly the communication between the children from abroad and the children who speak Japanese faces many difficulties. This study examined what is important to improve their communication. Two caregivers have made documents describing the characteristics of subject's communication for two years and some caregivers in the kindergarten have held conferences in which they revealed the relationship between the supports which caregivers have done and the changes of subject's communication. The result shows that it is important that (1) caregivers speak a word in Japanese with a corresponding word in subject's language, (2) caregivers attempt not to adapt subject's behavior to the classroom culture but to attract his/her interest in the classroom activities, and (3) caregivers and subject's parents get to know each other

Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo

Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level