Mn\mathcal{M}_n is connected

We consider the sets of zeros of some families of power series. We prove that the sets of zeros in the unit disk are connected. Furthermore, we apply this result to the study of the connectedness locus $\mathcal{M}_n$ for fractal $n$-gons. We prove that for each $n$, $\mathcal{M}_n$ is connected.Comment: 17 pages, and 2 figure

THE HAUSDORFF DIMENSION OF SOME PLANAR SETS WITH UNBOUNDED DIGITS

We consider some parameterized planar sets with unbounded digits. We investigate these sets by using the method of “transversality”, which is the main tool in investigating self-similar sets with overlaps. We calculate the Hausdorff dimension of these sets for typical parameters in some region with respect to the 2-dimensional Lebesgue measure. In addition, we estimate the local dimension of the exceptional set of parameters

Z_N Structure of Deconfinement Vacuum and Emergence of a Nambu-Goldstone Mode in the large-N Yang-Mills Theory

In this study, we use lattice QCD formalism to analyze the structure of spontaneously broken Z_N symmetry in the deconfinement vacuum of SU(N) pure Yang-Mills theory at high temperatures, with a focus on the large-N limit. We extend the conventional SU(3) strong-coupling model to the more general SU(N) gauge theory case and consider an effective action of the Yang-Mills theory associated with the Polyakov loops. First, we examine local fluctuations around a chosen vacuum in the Z_N-broken deconfinement phase, and show that in the large-N limit, the fluctuation in a certain direction becomes a quasi-Nambu-Goldstone mode. This mode exhibits spatially long-range correlation in the Z_N-broken vacuum. Second, we consider global vacuum-to-vacuum transitions in the Z_N-broken system with finite volume, which can be observed in quark-gluon-plasma phases created in high-energy heavy-ion collisions. We calculate the vacuum instability as a function of N and volume, and discuss the properties of Z_N-broken domains in the quark-gluon-plasma phase.Comment: 15 pages, 8 figure

The Hausdorff dimension of some planar sets with unbounded digits (Recent Developments in Dynamical Systems and their Applications)

反復関数系の自然な類推で，作用する関数の組が単位時刻に依って構わない関数系を非自励的反復関数系という．本講演で扱う非自励的反復関数系は，単位円盤内の点でパラメータ付けられ，単位時刻毎に作用する関数の組は常に，平面上の二つの縮小的な「線形写像」からなるが，二つのうち片方は，時刻が無限大にいくにつれ無限大に発散する平行移動項（ディジットと呼ぶ）を有するものを考えるすると，単位円盤内の点でパラメータ付けられた極限集合が定義される．上記設定下で，「横断性」という性質を持つパラメータ集合上の二次元ルベーグ測度に関するほとんど全てのパラメータに対応した極限集合のハウスドルフ次元を計算するまた，例外的なパラメータ集合のハウスドルフ次元の上からの評価も与える

慢性肺疾患の早産児におけるプロテインC経路 : 前向き研究

Background: Chronic lung disease (CLD) is a major neonatal pulmonary disorder associated with inflammation. Recent studies have shown that protein C anticoagulant pathways, such as those for protein C (PC), protein S (PS), and thrombomodulin (TM), could be useful indices for reflecting pulmonary injury. However, the involvement of these factors in preterm infants with very low birthweight (VLBW) who have developed CLD remains to be investigated. Here, we investigated whether PC pathway-related factors could predict the development of CLD in preterm infants with VLBW. Methods: We collected plasma samples from 26 preterm infants with VLBW (13 each from those with and without CLD) at the time of birth and measured TM, PC, and PS levels in their plasmas. We analyzed prospectively the relationship between these factors in infants with and without CLD. Results: There were significant differences in gestational age, birthweight, Apgar score (5 min), and duration of mechanical ventilation between the CLD and non-CLD groups. No significant differences in the PC and PS levels at birth were observed between the two groups, whereas the TM levels in the CLD group were significantly higher than those in the non-CLD group (P = 0.013). The TM levels correlated with gestational age and duration of mechanical ventilation. However, covariance analysis demonstrated that gestational age was significantly associated with TM levels, and consequently, development of CLD was not associated with TM level at birth. Conclusions: Thrombomodulin, PC, and PS levels at birth could not predict the development of CLD in preterm infants with VLBW.博士（医学）・甲第850号・令和4年9月28日© 2022 Japan Pediatric Society.This is the peer reviewed version of the following article: [https://onlinelibrary.wiley.com/doi/10.1111/ped.15221], which has been published in final form at [https://doi.org/10.1111/ped.15221]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.発行元が定める登録猶予期間終了の後、本文を登録予定（2023.01

Development of fast-response PPAC with strip-readout for heavy-ion beams

A strip-readout parallel-plate avalanche counter (SR-PPAC) has been developed aiming at the high detection efficiency and good position resolution in high-intensity heavy-ion measurements. The performance was evaluated using 115 MeV/u $^{132}$Xe, 300 MeV/u $^{132}$Sn, and 300 MeV/u $^{48}$Ca beams. A detection efficiency beyond 99% for these beams is achieved even at an incident beam intensity of 0.7 billion particles per second. The best position resolution achieved is 235 um (FWHM).Comment: 16 pages, 18 figures, 2 table

MCL1 inhibition is effective against a subset of small-cell lung cancer with high MCL1 and low BCL-XL expression

There have been few advances in the treatment of small-cell lung cancer (SCLC) because of the lack of targets. MCL1, a member of the anti-apoptotic BCL-2 family, may be a treatment target in several cancers, including SCLC. However, whether the expression profile of the anti-apoptotic BCL-2 family affects MCL1 inhibition strategy is unknown. A tissue microarray (TMA) was created from consecutive patients who were diagnosed with SCLC and had previously undergone surgery at Kyoto University Hospital (Kyoto, Japan) between 2001 and 2017. We used S63845, a MCL1 inhibitor, to assess the cytotoxic capacity in SCLC cell lines including a patient-derived cell line in vitro and in vivo. The combination of S63845 with navitoclax, a double BCL-XL/BCL-2 inhibitor, was also employed to examine the comprehensive inhibition of the anti-apoptotic BCL-2 family. Immunohistochemistry of a TMA from patients with surgically resected SCLC demonstrated high MCL1 expression with low BCL-XL and BCL-2 to be the most common expression profile. S63845 was effective in high MCL1- and low BCL-XL-expressing SCLC cell lines. S63845 induced BAK-dependent apoptosis in vitro, and the anti-tumor efficacy was confirmed in an in vivo model. Although knockdown of BCL-XL and BCL-2 improved the cytotoxic activity of S63845 and its combination with navitoclax increased the anti-tumor cytotoxicity, the therapeutic range of S63845 with navitoclax was narrow in in vivo studies. Our study suggests MCL1 inhibition therapy be applied for high MCL1- and low BCL-XL-expressing SCLC patients

Status of 48Ca double beta decay search in CANDLES

We study a strategy to reduce veto-time in the search for neutrino-less double-beta decay (0υββ) with CANDLES-III system. We develop a new likelihood analysis and apply it to our new Run010 data. We show that we can increase the un-vetoed live-time by 11.8%. Thanks to this improvements, We expect to increase a limit on the life-time of 0υββ by a factor of three by analyzing both Run009 and Run010 data