Roundabout relaxation: collective excitation requires a detour to equilibrium

Relaxation to equilibrium after strong and collective excitation is studied, by using a Hamiltonian dynamical system of one dimensional XY model. After an excitation of a domain of $K$ elements, the excitation is concentrated to fewer elements, which are made farther away from equilibrium, and the excitation intensity increases logarithmically with $K$. Equilibrium is reached only after taking this ``roundabout'' route, with the time for relaxation diverging asymptotically as $K^\gamma$ with $\gamma \approx 4.2$.Comment: 4 pages, 5 figure

肝臓がん遺伝子治療用T細胞受容体の選択と機能評価

金沢大学医薬保健研究域医学系研究課題/領域番号:15K21014, 研究期間(年度):2015-04-01 – 2018-03-31出典：研究課題「肝臓がん遺伝子治療用T細胞受容体の選択と機能評価」課題番号15K21014（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K21014/）を加工して作

In vivo immunological antitumor effect of OK-432-stimulated dendritic cell transfer after radiofrequency ablation

13301甲第4008号博士（医学）金沢大学博士論文要旨Abstract 以下に掲載：Cancer Immunology, Immunotherapy 63(4) pp.347-356 2014. Springer. 共著者：Hidetoshi Nakagawa, Eishiro Mizukoshi, Noriho Iida, Takeshi Terashima, Masaaki Kitahara, Yohei Marukawa, Kazuya Kitamura, Yasunari Nakamoto, Kazumasa Hiroishi, Michio Imawari, Shuichi Kanek

Analysis of coronary vascular development in an animal model of congenital heart disease - in vivo and in vitro studies to detect a role of proepicardial organ derived cells

科学研究費補助金研究成果報告書研究種目: 基盤研究(B)研究期間: 2004～2005課題番号: 16390299研究代表者: 中川 雅生（滋賀医科大学・医学部・講師）研究分担者: 藤野 英俊（滋賀医科大学・医学部・助手

Mechanism of coronary artery anomalies and myocardial growth disturbance in bis-diamine treated rat using whole embryo culture technique

科学研究費補助金研究成果報告書研究種目: 基盤研究(C)研究期間: 2001～2002課題番号: 13670797研究代表者: 中川 雅生（滋賀医科大学・医学部・講師）研究代表者: 藤野 英俊（滋賀医科大学・医学部・助手

Red thermoluminescence of enstatite from the Chainpur meteorite

For most ordinary chondrites feldspar is mainly responsible for thermoluminescence [TL], but in type 3 ordinary chondrites, especially those which are most primitive, other minerals are important. We observed red TL with a ∿660nm spectral peak in an ordinary chondrite, Chainpur (LL3.4). The mineral responsible for the red TL was identified as iron-free enstatite. Spatial distribution of TL and cathodoluminescence [CL] for the same specimen was also investigated, and it was found that the red TL areas corresponded to the high-sensitivity areas of red CL

A case of locally advanced adenosquamous carcinoma of the cecum with long-term survival

A 63-year-old woman was admitted to our hospital with a right lower abdominal mass and general fatigue. Preoperative examination suggested a large ovarian tumor or cecal carcinoma. However, her intraoperative diagnosis was colon cancer; we therefore performed an ileocecal resection with oophorectomy. The tumor was pathologically diagnosed as adenosquamous carcinoma T4bN1M-stage IIIa. We administrated CapeOX adjuvant chemotherapy for 6 months. Adenosquamous carcinoma is extremely rare, at around 0.1% of all colorectal cancers, and usually has a poor prognosis. The patient is still alive without recurrence after 84 post-operative months, even with later developments of metachronous early colorectal cancer and breast cancer. We herein report a rare case of cecal ASC with good prognosis

Noninvasive assessment of the cardiac baroreflex Response to downward tilting and comparison with the phenylephrine method

AbstractOBJECTIVESWe studied the relation between changes in systolic blood pressure and RR interval during downward tilting in comparison with assessment of baroreflex sensitivity (BRS) measured by the phenylephrine method (Phe-BRS) and with measures of heart rate variability (HRV).BACKGROUNDThe method most extensively used for assessing BRS involves bolus injections of phenylephrine. Several noninvasive methods proposed to assess BRS have not been widely applied in the clinical setting.METHODSSixteen healthy male volunteers were studied (mean age ± SD 27.5 ± 4.6 years). Arterial blood pressure using tonometry and electrocardiogram was simultaneously recorded. After 20 min of 70° upright tilting, the table was returned to supine position at a speed of 3.2°/s. Subsequently, BRS was assessed using an intravenous bolus injection of phenylephrine (2 to 3 μg/kg). Heart rate variability under resting conditions also was analyzed.RESULTSIn all subjects, a beat to beat systolic blood pressure increase associated with corresponding RR interval lengthening was observed during downward tilting as well as during phenylephrine administration. During both testing procedures, these two variables showed linear correlation, and the slope of regression line during downward tilting (DT-BRS) correlated significantly with Phe-BRS (r = 0.79, p = 0.0003). The DT- and Phe-BRS also correlated significantly with the high frequency component of resting HRV (r = 0.70, p = 0.0023 for DT-BRS; r = 0.58, p = 0.0185 for Phe-BRS).CONCLUSIONSWe conclude that in a small homogeneous group DT-BRS provided an assessment of reflex cardiac vagal function comparable to that obtained by the phenylephrine method

Antitumor effect after radiofrequency ablation of murine hepatoma is augmented by an active variant of CC chemokine ligand 3/macrophage inflammatory protein-1á

金沢大学医薬保健研究域医学系Several chemokines are used for immunotherapy against cancers because they can attract immune cells such as dendritic and cytotoxic T cells to augment immune responses. Radiofrequency ablation (RFA) is used to locally eliminate cancers such as hepatocellular carcinoma (HCC), renal cell carcinoma, and lung cancer. Because HCC often recurs even after an eradicative treatment with RFA, additional immunotherapy is necessary. We treated tumor-bearing mice by administering ECI301, an active variant of CC chemokine ligand 3, after RFA. Mice were injected s.c. with BNL 1ME A.7R.1, a murine hepatoma cell line, in the bilateral flank. After the tumor became palpable, RFA was done on the tumor of one flank with or without ECI301. RFA alone eliminated the treated ipsilateral tumors and retarded the growth of contralateral non-RFA-treated tumors accompanied by massive T-cell infiltration. Injection of ECI301 augmented RFA-induced antitumor effect against non-RFA-treated tumors when administered to wild-type or CCR5-deficient but not CCR1-deficient mice. ECI301 also increased CCR1-expressing CD11c+ cells in peripheral blood and RFA-treated tumors after RFA. Deficiency of CCR1 impairs accumulation of CD11c+, CD4+, and CD8+ cells in RFA-treated tumors. Furthermore, in IFN-ã-enzyme-linked immunospot assay, ECI301 augmented tumor-specific responses after RFA whereas deficiency of CCR1 abolished this augmentation. Thus, we proved that ECI301 further augments RFA-induced antitumor immune responses in a CCR1-dependent manner. ©2010 AACR