Swashbuckling in Vietnam: Reading American Mythical Landscapes in Robin Moore’s The Green Berets

　Drawing upon previous studies on American Vietnam War literature and the myth of the frontier, America’s dominant national creation myth that romanticizes European settlers’ violent confrontation with native Americans in the New World wilderness, this essay examines Robin Moore’s novel The Green Berets (1965), one of the earliest American fictions to write about the war. It contends that Moore tries to define the land and the people of Vietnam in terms heavily loaded with the conventional images of the frontier mythology, and that those images helped to form the society’s earliest view on the war. 　This essay reads Moore’s Vietnam combat novel with a special focus upon “Home to Nannette,” a chapter that recounts a Special Forces man’s secret mission to fight with Communist guerrilla forces in Laotian mountains. Narrating the protagonist’s lonesome, perilous journey into the heart of Indochinese wilderness, its plot bears striking similarities to that of what Amy Kaplan calls “swashbuckling romances,” popular historical novels widely read in the latenineteenth-century America. Both Moore’s Vietnam novel and nineteenthcentury historical romances have a white American male endowed with traditional virtues of frontiersmen as their protagonist and dramatizes his violent adventure and romance with an exotic, native woman in foreign landscapes. This essay attempts an in-depth investigation into the narrative similarities between the two to understand further the colonial ideology that underlies Moore’s Vietnam War novel and its close ties with the myth of the frontier

Vietnam fought and imagined: the images of the mythic frontier in American Vietnam War literature

This thesis seeks to examine how a particularly American ideological formation called the frontier myth has been re-enacted, challenged, and redefined in the literary works written by several American authors. Existing researches about the pervasiveness of the frontier mythology in American culture written by scholars such as Richard Slotkin, Richard Drinnon, and others demonstrate that, as the myth of the frontier–––the popular discourse that romanticizes early white settlers’ violent confrontation with American Indians in the New World wilderness–––has been deeply inscribed in America’s collective consciousness, when they faced with the war in a remote Southeast Asian country, many Americans have adopted its conventional narrative patterns, images, and vocabulary to narrate their experiences therein. The word, Indian Country–––a military jargon that US military officers commonly used to designate hostile terrains outside the control of the South Vietnamese government–––would aptly corroborate their argument. Drawing upon Edward Said’s exegesis of a structure of power that privileged Europeans assumed when they gazed at and wrote about the place and people categorized as “Oriental,” I contend that the images of the frontier frequently appearing in US Vietnam War accounts are America’s “imaginative geography” of Vietnam. By closely looking at the Vietnamese landscapes that American authors describe, I intend to investigate the extent to which the authors’ view of Vietnam are informed, or limited, by the cultural imperatives of the myth. At the same time, I will also look for instances in which the authors attempt to challenge the very discourse that they have internalized. I will read several novels and stories of American Vietnam War literature in a loosely chronological manner––from earlyier American Vietnam novels such as William Lederer’s and Eugene Burdick’s The Ugly American (1958), through three notable Vietnam–vet writers’ works published between the late ’70s and ’90s that include Tim O’Brien’s Going After Cacciato (1978) and The Things They Carried (1990), to Denis Johnson’s Tree of Smoke (2007), a recent novel produced after 9/11. Hereby, I aim to explain the larger cultural/political significances that underlie the images of the frontier appearing in American Vietnam War narratives, and their vicissitude through time. While the authors of early US Vietnam War narratives reproduced stereotypical representations of the land and people of Vietnam that largely reflected the colonial/racist ideologies embedded in the myth, the succeeding generations of authors, with varying degrees of success, have undermined what has conventionally been regarded as America’s master narrative, by, for instance, deliberately subverting the conventional narrative patterns of the frontier myth, or by incorporating into their narratives the Vietnamese points of view that have often been omitted in earlier US Vietnam War accounts

Murdering the Myth of America’s Cultural Fathers: Reading Denis Johnson’s Tree of Smoke as an Updated Critique of America’s Frontier Mythology

In this paper, I will read Denis Johnson’s Tree of Smoke (2007), asserting that, throughout his massive Vietnam novel, the author resists the revisionist discourse to reinterpret Vietnam as America’s noble effort emerging amidst the tide of the nationwide anger and victimhood in the aftermath of 9/11. Like several previous US authors, Johnson depicts the battlefield of Vietnam as an anti-frontier that frustrates American male characters’ expectations to reenact their mythic fathers’ heroic adventures. However, comparing, in particular, the portrayals of WW II veteran characters in Johnson’s novel and O’Brien’s Going After Cacciato, I would argue that the former’s nightmarish vision of the inverted frontier more thoroughly questions the legitimacy of America’s myth about its essential goodness and power

Criticising the Metaphor of Vietnam as a Diseased Land: Stephen Wright’s Meditations in Green

　This essay firstly focuses upon the images of a “diseased land” and “vermin–like natives” that were commonly used by American military personnel to describe the land and the people of Vietnam. Referring to Francis Fitzgerald’s classic study of the war, I would argue that those images reflect America’s desires to place Vietnam in its mythological perspective, to downplay the complexities of the conflict, and to make it a simplistic battle between good and evil. By figuring Vietnam and its people as insanitary and disease-ridden, and, in turn, describing US military as a physician bound by a moral oath to sanitize/medicate the Vietnamese land and people, US military officials in effect endorsed their aggressive actions against Vietnam, including the use of chemical defoliants and napalm bombing.　　The discussion about the pathologized images of Vietnam leads us to examine Vietnam-vet author Stephen Wright’s novel Meditations in Green (1983), which attempts to criticize America’s neocolonialism by explicating the racist/colonialist ideologies underlying those images. The protagonist of the novel is James I. Griffin, an herbicide researcher working for the army’s Agent Orange operation in Vietnam. By narrating the war through the protagonist’s unique perspective, Wright describes US military’s erroneous efforts to control/sanitize the resilient forces of the Vietnamese natural world, which American officials regard as cumbersome, diseased, and insanitary. Informed by Susan Sontag’s reflection on illness as metaphor, I will especially illuminate the ways in which Wright challenges the discourse of diseased Vietnam, by destabilizing the binary oppositional imagery of the technologically advanced American order and the backward, unsanitary Vietnamese chaos that Americans have fabricated

A novel superior factor widely controlling the rice grain quality

Synthesis of storage starch and protein accumulation is the main action of endosperm organogenesis in term of the economic importance of rice. This event is strongly disturbed by abiotic stresses such as high temperature; thus, the upcoming global warming will cause a crisis with a great impact on food production^1,2^. The enzymes for the protein storage and starch synthesis pathway should work in concert to carry out the organogenesis of rice endosperm^3-5^, but the regulatory mechanism is largely unknown. Here we show that a novel regulatory factor, named OsCEO1, acts as the conductor of endosperm organogenesis during the rice grain filling stage. The physiological properties of _floury-endosperm-2_ (_flo2_) mutants showed many similarities to symptoms of grains developed under high-temperature conditions, suggesting important roles of the responsible gene in sensitivity to high-temperature stress. Our map-based cloning identified the responsible gene for the _flo2_ mutant, _OsCEO1_, which has no homology to any genes of known function. The _OsCEO1_ belongs to a novel conserved gene family and encodes a protein composed of 1,720 amino acid residues containing a TPR (tetratricopeptide repeat) motif, which is considered to mediate a protein-protein interaction. The yeast two-hybrid analysis raised an unknown protein showing homology to a late embryogenesis abundant protein and a putative basic helix-loop-helix protein as candidates for the direct interactor for _OsCEO1_, whereas no enzyme genes for the synthesis of storage substances were detected. The _flo2_ mutant exhibited reduced expression of several genes for putative regulatory proteins as well as many enzymes involved in storage starch and proteins. These results suggest that _OsCEO1_ is a superior conductor of the novel regulatory cascade of endosperm organogenesis and may have important roles in the response to high-temperature stress

Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes

Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload. Mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that regulates cell growth, metabolism, and survival. We have shown previously that mTOR activity is increased in response to myocardial ischemia-reperfusion injury. However, whether Trx1 interacts with mTOR to preserve heart function remains unknown. Using a substrate-trapping mutant of Trx1 (Trx1C35S), we show here that mTOR is a direct interacting partner of Trx1 in the heart. In response to H2O2 treatment in cardiomyocytes, mTOR exhibited a high molecular weight shift in non-reducing SDS-PAGE in a 2-mercaptoethanol-sensitive manner, suggesting that mTOR is oxidized and forms disulfide bonds with itself or other proteins. The mTOR oxidation was accompanied by reduced phosphorylation of endogenous substrates, such as S6 kinase (S6K) and 4E-binding protein 1 (4E-BP1) in cardiomyocytes. Immune complex kinase assays disclosed that H2O2 treatment diminished mTOR kinase activity, indicating that mTOR is inhibited by oxidation. Of note, Trx1 overexpression attenuated both H2O2-mediated mTOR oxidation and inhibition, whereas Trx1 knockdown increased mTOR oxidation and inhibition. Moreover, Trx1 normalized H2O2-induced down-regulation of metabolic genes and stimulation of cell death, and an mTOR inhibitor abolished Trx1-mediated rescue of gene expression. H2O2-induced oxidation and inhibition of mTOR were attenuated when Cys-1483 of mTOR was mutated to phenylalanine. These results suggest that Trx1 protects cardiomyocytes against stress by reducing mTOR at Cys-1483, thereby preserving the activity of mTOR and inhibiting cell death

Lower FEV1 in non-COPD, nonasthmatic subjects: association with smoking, annual decline in FEV1, total IgE levels, and TSLP genotypes

Few studies have investigated the significance of decreased FEV1 in non-COPD, nonasthmatic healthy subjects. We hypothesized that a lower FEV1 in these subjects is a potential marker of an increased susceptibility to obstructive lung disease such as asthma and COPD. This was a cross-sectional analysis of 1505 Japanese adults. We divided the population of healthy adults with no respiratory diseases whose FEV1/FVC ratio was ≥70% (n = 1369) into 2 groups according to their prebronchodilator FEV1 (% predicted) measurements: <80% (n = 217) and ≥80% (n = 1152). We compared clinical data – including gender, age, smoking habits, total IgE levels, and annual decline of FEV1 – between these 2 groups. In addition, as our group recently found that TSLP variants are associated with asthma and reduced lung function, we assessed whether TSLP single nucleotide polymorphisms (SNPs) were associated with baseline lung function in non-COPD, nonasthmatic healthy subjects (n = 1368). Although about half of the subjects with lower FEV1 had never smoked, smoking was the main risk factor for the decreased FEV1 in non-COPD, nonasthmatic subjects. However, the subjects with lower FEV1 had a significantly higher annual decline in FEV1 independent of smoking status. Airflow obstruction was associated with increased levels of total serum IgE (P = 0.029) and with 2 functional TSLP SNPs (corrected P = 0.027–0.058 for FEV1% predicted, corrected P = 0.015–0.033 for FEV1/FVC). This study highlights the importance of early recognition of a decreased FEV1 in healthy subjects without evident pulmonary diseases because it predicts a rapid decline in FEV1 irrespective of smoking status. Our series of studies identified TSLP variants as a potential susceptibility locus to asthma and to lower lung function in non-COPD, nonasthmatic healthy subjects, which may support the contention that genetic determinants of lung function influence susceptibility to asthma

Portal Venous Gas Following Ingestion of Hydrogen Peroxide Successfully Treated with Hyperbaric Oxygen Therapy

The primary toxicity of hydrogen peroxide results from its interaction with catalase, which liberates water and oxygen. We report the case of a 14-year-old Japanese girl with portal venous gas that was caused by oxygen liberated from intentionally ingested hydrogen peroxide. Although she had a past history of atrial septal defect, recovery without cardiac or neurological sequelae was achieved using hyperbaric oxygen therapy. Emergency physicians must be aware of the danger of liberated oxygen due to hydrogen peroxide ingestion

Neonatal Lethality in Knockout Mice Expressing the Kinase-Dead Form of the Gefitinib Target GAK Is Caused by Pulmonary Dysfunction

Gefitinib (Iressa) is an inhibitor of the epidermal growth factor receptor (EGFR) that has shown promising activity in the treatment of patients with non-small cell lung cancer (NSCLC). However, adverse side effects of gefitinib treatment, such as respiratory dysfunction, have limited the therapeutic benefit of this targeting strategy. The present results show that this adverse effect can be attributed to the inhibition of the novel gefitinib target GAK (Cyclin G-associated kinase), which is as potently inhibited by the drug as the tyrosine kinase activity of EGFR. Knockout mice expressing the kinase-dead form of GAK (GAK-kd) died within 30 min after birth primarily due to respiratory dysfunction. Immunohistochemical analysis revealed that surfactant protein A (SP-A) was abundant within alveolar spaces in GAK-kd+/+ mice but not in GAK-kd-/- pups. E-cadherin and phosphorylated EGFR signals were also abnormal, suggesting the presence of flat alveolar cells with thin junctions. These results suggest that inhibition of GAK by gefitinib may cause pulmonary alveolar dysfunction, and the present study may help prevent side effects associated with gefitinib therapy in NSCLC patients