3 research outputs found
An Appraisal of the Marine Fisheries of Karnataka and Goa
Karnataka, on the West coast, plays an important role in the fisheries
development of India and has a prominent place in the country's fisheries map,
It has a shelf area of 25000 Sq. Km. and a coastline of 270 Km, about 1/22 of
the country's coastline. The State's contribution to the total marine fish production
in the country is of the order of ^.0%. The State has two coastal
districts, namely Dakshin Kannada and Uttar Kannada. The lengths of coastline
of both the districts are almost the same. Many rivers such as the Nethravathi,
the Saravathi and the Kali flow into the Arabian sea and render the inshore
area rich in nutrients
A study of the thermal decomposition of allyl t-butyl peroxide and 3-hydroperoxy-1-propene (allyl hydroperoxide) in toluene /|nby Krishnankutty Nair V. G. -- 260 St. Catharines [Ont. : s. n.],
Kinetics and product studies of
the decompositions of allyl-t-butyl peroxide and 3-hydroperoxy-
l-propene (allyl hydroperoxide ) in tolune were investigated.
Decompositions of allyl-t-butyl peroxide in toluene at 130-1600
followed first order kinetics with an activation energy of
32.8 K.cals/mol and a log A factor of 13.65. The rates of decomposition
were lowered in presence of the radical trap~methyl
styrene. By the radical trap method, the induced decomposition
at 1300 is shown to be 12.5%. From the yield of 4-phenyl-l,2-
epoxy butane the major path of induced decomposition is shown
to be via an addition mechanism. On the other hand, di-t-butYl
peroxyoxalate induced decomposition of this peroxide at 600
proceeded by an abstraction mechanism. Induced decomposition
of peroxides and hydroperoxides containing the allyl system is
proposed to occur mainly through an addition mechanism at these
higher temperatures. Allyl hydroperoxide in toluene at 165-1850
decomposes following 3/2 order kinetics with an Ea of 30.2 K.cals
per mole and log A of 10.6. Enormous production of radicals
through chain branching may explain these relatively low values
of E and log A. The complexity of the reaction is indicated a
by the formation of various products of the decomposition. A
study of the radical attack of the hydro peroxide at lower temperatures
is suggested as a further work to throw more light on
the nature of decomposition of this hydroperoxide
ROS Dependent Antifungal and Anticancer Modulations of Piper colubrinum Osmotin
Osmotin, a plant defense protein, has functional similarity to adiponectin, an insulin sensitizingsensitising hormone secreted by adipocytes. We speculated that Piper colubrinum Osmotin (PcOSM) could have functional roles in obesity-related cancers, especially breast cancer. Immunofluorescence assays, flow cytometry, cell cycle analysis and a senescence assay were employed to delineate the activity in MDAMB231 breast cancer cell line. PcOSM pre-treated P. nigrum leaves showed significant reduction in disease symptoms correlated with high ROS production. In silico analysis predicted that PcOSM has higher binding efficiency with adiponectin receptor compared to adiponectin. PcOSM was effectively taken up by MDAMB231 cancer cells which resulted in marked increase in intracellular ROS levels leading to senescence and cell cycle arrest in G2/M stage. This study provides evidence on the ROS mediated direct inhibitory activity of the plant derived osmotin protein on the phytopathogen Phytophthora capsici, and the additional functional roles of this plant defense protein on cancer cells through inducing ROS associated senescence. The strong leads produced from this study could be pursued further to obtain more insights into the therapeutic potential of osmotin in human cancers