8 research outputs found
PANC Study (Pancreatitis: A National Cohort Study): national cohort study examining the first 30 days from presentation of acute pancreatitis in the UK
- Author
- Aal Yasser Abdul
- Abbadessa Francesco
- Adesuyi Abidemi
- Adiamah Alfie
- Afza Asma
- Ahmad Jawad
- Ahmad Mustafa Nabeel
- Ahmed Shehzad
- Ain Quratul
- Al-Azzawi Marwa
- Al-Hamed Layal
- Al-Hijaji Mohammed
- Al-Rashedy Mohammed
- Alamassi Amro
- Albalkiny Sherif
- Alfred Joshua
- Ali Sakhawat
- Ali Uzair
- Amir Farhat
- Anele Chukwuemeka
- Angamuthu Natarajan
- Anyomih Theophilus
- Apollos Jeyakumar
- Arambepola Devika
- Argyropoulos Susannah
- Aroori Somaiah
- Arumugam Danaradja
- Arumugam Sathyaseelan
- Assaf Nazrin
- Athwal Tejinderjit
- Awan Altaf
- Azam Saima
- Babalola Olaitan
- Baker Annalie
- Bandyopadhyay Samik
- Banerjee Amlan
- Bardoli Antonio
- Barman Sowrav
- Baron Ryan
- Bashiti Hazem
- Basra Nersheranjeet
- Beatson Kevin
- Bee Charlotte
- Behmida Rami
- Belgaumkar Ajay
- Bell Richard
- Beniwal Abhijeet
- Benjafield Anastasia
- Bennett John
- Berry David
- Bevan Katharine
- Beynon Victoria
- Bhandari Mayank
- Bharucha Shameena
- Bhat Srushti
- Bhatti Sumbal
- Blacklock Callum
- Bleything Zoe
- Bodla Ahmed Salman
- Body Samantha
- Bond Amanda
- Bond-Smith Giles
- Bonomaully Matthew
- Borakati Aditya
- Borg Cynthia-Michelle
- Bota Emil
- Bourne Hannah
- Boven Carine
- Bradley Alison
- Brignall Rhiannon
- Brindle Rachel
- Britton Emily
- Brooks Adam
- Brown Ashley
- Brown Keiran
- Buhain Robert
- Buksh Mahfooz
- Burridge Isobel
- Byrom Richard
- Caldwll Jade
- Cambridge William
- Carr Jenna
- Chakravartty Saurav
- Chan Juen Hao
- Chase Thomas JG
- Chhabra Raunaq
- Chidumije Nnaemeka
- Chin Carven
- Choa George
- Choh Clarisa Thian Puay
- Chohda Ezzat
- Chowdhury Shihab
- Clark James
- Clark Robert
- Claxton Mary
- Clayton Bethan
- Clifford Rachael
- Coe Peter O
- Coles Jennifer
- Collins Alma
- Collins Chris
- Conroy Soraya
- Convie Liam
- Cotton Arthur
- Courtney Michael
- Cowie Stuart
- Craig Eoin
- Cromwell Paul
- Currow Chelise
- Dai Nick
- Damaskos Dimitrios
- Davidson Brian R
- Davis George N
- De Prendergast Alexandra
- Delaney Christopher
- Dhannoon Amenah
- Di Franco Filippo
- Di Mauro Davide
- Difford Tabitha
- DiMaggio Francesco
- Doshi Neel
- Dosis Alexios
- Duncan James
- Dunne Declan
- Dyer Sarah
- Ebied Husam
- Ebraheem Mohamed
- Edwards Katie
- El-Abbassy Islam
- Elkalbash Rema
- Elnaghi Mohamed
- Elnogoomi Ahmed
- Elserafy Amr
- Etherson Kevin
- Eves Peter
- Fagan Leah
- Fallis Simon
- Farrow Emily
- Farrugia Alexia
- Faulkner Gemma
- Ferguson Chanoka
- Finch Guy
- Findlay Alasdair
- Findlay John
- Fisher Simon
- Foster Kate
- Fox Katherine
- Frampton Adam
- Fraser Tessa
- Freeman Rebecca
- Froghi Farid
- Gaber Mohannad
- Gadhvi Adam
- Gala Tanzeela
- Galanopoulos Georgios
- Galea Mark
- Gallagher Tom K
- Gammeri Emanuele
- Gemmill Elizabeth
- Gerogiannis Ioannis
- Ghaneh Paula
- Gilmore Catherine
- Girard Louis-Pierre
- Gismondi Martha
- Golpe Antonio Leyte
- Gray Joanna
- Grey Grace
- Griffith David
- Gulnaz Nadia
- Gunia Dariusz
- Gupta Aayush
- Gupta Ajay
- Gurung Ganga
- Hakeem Abdul
- Halloran Christopher
- Hamid Hytham KS
- Hanbali Nabih
- Handa Siddhartha
- Haq Ehsan Ul
- Harris Chad
- Harrison William
- Hart Patrick
- Hassan Asma
- Hassasing Sapna
- Hawkins William
- Healey Albert
- Heaphy Deborah
- Heer Priya
- Heugh Claire
- Hollyman Marianne
- Hou David
- Hudson Victoria E
- Huppler Lucy
- Husain Najam
- Ibrahim Basil
- Ireland Philip
- Isand Karl
- Islam Muhammad Ariful
- Itobi Emmanuel
- Jackman Jamaall
- Jalil Omar Abdel
- Jamieson Elias
- Janardhanan Pradeep
- Javanmard-Emamghissi Hannah
- Jayawardena Panduka
- Jenkins Bethan
- Johnstone Callum
- Jones Andrew
- Jones Michael
- Jones Rebecca M
- Jones Simon
- Kadambot Safwan Shafeeque
- Kaistha Sumesh
- Kanakala Venkatesh
- Kansal Nisheeth
- Karagiannidis Georgios
- Katbeh Tarek
- Kaul Anil
- Kenington Cleo
- Kennedy-Dalby Andrew
- Kerans George
- Khaddar Ziad Al
- Khalid Ayesha
- Khalil Amjad
- Khalil Hany
- Khan Amnah
- Khan Hamad
- Khanna Chaitra
- Khor Bo Yuan
- Kim Hyun
- Kirmani Naveed
- Knight Stephen R
- Ko Kar Yeung Kenneth
- Koh Amanda
- Kong Keh
- Korwar Vijay
- Kosti Angeliki
- Kourdouli Amar
- Krzak Ada Maria
- Kumar Anil
- Kumar Bhaskar
- Kumar Nagappan
- Kumar Rahul Mohan
- Kuzman Matta
- Kyriakides Charis
- Lahiri Rajiv
- Laing Richard W
- Lango Artemisia
- Larsen Katy
- Latif Javed
- Lavery Lauren
- Lawther Roger
- Lee Rachel Xue Ning
- Lees Bryony
- Lenzi Elisa
- Leswas Dhya Al
- Levy Raphael
- Lim Jie
- Lim Rachel Qian Hui
- Lloyd Emily
- Lo Tammy
- Lo Terence
- Longbotham David
- Luhmann Andreas
- Lund Jonathan N
- Lunevicius Raimundas
- Mack Eleanor
- Magro Tania
- Mahgoub Ahmed
- Majid Shaukat
- Malam Yogeshkumar
- Maliyil Jed
- Manby Paul
- Mann Kulbir
- Manzelli Antonio
- Marriott Paul
- Marsh Luke
- Martin Allie
- Martin Julia
- Mashar Ruchir
- Massella Virginia
- Mathew Malayil
- May-Miller Peter
- McCabe Gerard
- McCallion Stephen
- McCrorie Alan
- McGarry Jennifer
- Meilak Joseph
- Menezes Neville
- Menon Ashok
- Merali Nabeel
- Michel Martin
- Milburn James
- Minicozzi Annamaria
- Mistry Pritesh
- Mitra Smrthi
- Mitton David
- Mohamed Mohamed Saleem Noor
- Mohamed Samy
- Mohammadi-Zaniani Ghazaleh
- Mole Damian
- Moran Emily
- Morrison-Jones Victoria
- Moug Susan J
- Muhammad Fahad Ullah
- Mukherjee Rajarshi
- Murali Navanith
- Murphy Ben
- Murray Hannah
- Mustafa Abdalla
- Muthukumarasamy Girivasan
- Nair Ashitha
- Naqvi Ahmed
- Naqvi Mushal
- Nawaz Ghulam
- Nayar Manu
- Nazir Shahani
- Needham Paul
- Neophytou Christodoulos
- Newman Matthew
- Newton Lydia
- Ng Hwei Jene
- Ng Sherwin
- Ng Vivian
- Nip Lawrence
- Nizami Kulsoom
- Nunes Quentin
- O'Connor Olivia
- Oh Ke En
- Oliphant Raymond
- Olivier James
- Ong Seok Ling
- Ooi Setthasorn Zhi Yang
- Osilli Dixon
- Owen Amy
- Oyende Olamide
- Oyewole Bankole
- O’Kelly James
- Pandanaboyana Sanjay
- Parekh Vishal
- Parmar Chetan
- Patel Ameet G
- Patel Ishaan
- Patel Kamlesh
- Patel Panna
- Patel Puja
- Patel Rikhilroy
- Patel Roshni
- Patil Pradeep
- Patnam Varun
- Pawlik Olga
- Pearman Douglas
- Peleki Katerina
- Pervez Ahmed
- Phillips Simon
- Piramanayagam Balasubramanian
- Popa Mariuca
- Porter Darren
- Pournaras Dimitri J
- Powezka Katarzyna
- Prabhu Aishwarya
- Prasanth Manju Nadh
- Presa Roberto
- Puri Aiysha
- Qayum Mohammed Kaif
- Quddus Abdul
- Rahman Rafid
- Rai Jason
- Rajamanickam Shenbaga Kumar
- Rajebhosale Ramprasad
- Rajendran Ilayaraja
- Rajput Kunal
- Ransome Marina
- Rao Milind
- Rao Pawan Kumar Dhruva
- Rao Sudhi
- Rarity Michael
- Rashid Muhammad Umair
- Ravi Prabhu
- Razi Kasra
- Regan Azel
- Richardson Tom
- Rink James
- Roberts Keith J
- Roslan Farah
- Rottenburg Hannah
- Royle James
- Rozwadowski Sophie
- Rybinski Blazej
- Ryska Ondrej
- Saafan Tamer
- Saeed Samerah
- Saha Arin
- Sahl Abdullah Bin
- Saint-Grant Alexander Les
- Saleh Dina
- Salinas Camila Hidalgo
- Sallam Ali
- Sallam Mahmoud
- Sarathy Kasturi
- Sarmah Panchali
- Sawdon Lauren
- Schuijtvlot Nicolaas
- Seeralakandapalan Sarangan
- Sellahewa Sujeewa
- Seretny Luke
- Seta Pooja
- Seymour Keith
- Shah Nehal Sureshkumar
- Shajpal Arjun
- Shamali Awad
- Shanti Hiba
- Sharp Catherine
- Shikh-Bahaei Tamanna
- Shirazi Shahram
- Sivakumar Aran
- Small Sarah
- Smart Chris J
- Smith Andrew M
- Spearman John
- Spellar Kayleigh
- Spiers Harry VM
- Spurring Eleanor
- Strachan David
- Sutton Robert
- Szatmary Peter
- Taha Ahmed
- Talbot Adam
- Tan Yan Yu
- Tanaka Ermal
- Tandon Ashutosh
- Tasleem Sadia
- Tawfik Ahmed
- Taylor Mark
- Telfah Muwaffaq
- Tezas Stergios
- Thanki Sonam
- Thomas Joel
- Tierney Gillian M
- Toh Wei
- Toh Wei Hann
- Toumi Zaher
- Tucker Sophie
- Van Boxel Gijs
- van Laarhoven Stijn
- Varma Aarti
- Vaz Osborne
- Virupaksha Suvi
- Wadley Martin
- Wajed Saj
- Walker Cerys
- Walker Thomas
- Ward Thomas
- Watton Leo
- Wei Rui
- Welsh Joshua
- White Annabelle
- Whitelaw Douglas
- Wiggins Tom
- Wijeyaratne Manuk
- Williams Olatoyosi
- Willis Kevin
- Wilson Iain
- Wilson Michael
- Wolstenholme Caroline
- Wong Alicia
- Wong Grace
- Worku Dawit
- Wright Hannah
- Wyatt Craig
- Yahia Shuker
- Yassin Nuha
- Yeung Denise
- Young John
- Youssef Fahed
- Zafar Muneeb
- Zafar Shahbaz
- Zakeri Roxanna
- Zourob Mohammed
- Zuccarrelli Andrea
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 10/05/2023
- Field of study
Abstract
Background
Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment.
Methods
All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals.
Results
A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death.
Conclusion
Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions.
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- Author
- Adeniji Kayode
- Aggleton John P.
- Agranoff Daniel
- Agwuh Ken
- Ahmed Katie A.
- Ail Dhiraj
- Al-Chalabi Ammar
- Aldera Erin L.
- Alegria Ana
- Alex Beatrice
- Allen Christopher M.
- Allen Sam
- Amin Jay
- Andrikopoulos Petros
- Angus Brian
- Armour Cherie
- Armstrong Jane A.
- Ashish Abdul
- Ashworth Milton
- Asiimwe Innocent G.
- Atkinson Dougal
- Bach Benjamin
- Baillie J. Kenneth
- Baillie J. Kenneth
- Baker Mark R.
- Bakshi Siddharth
- Barclay Wendy S.
- Bari Shahedal
- Barlow Gavin
- Barlow Samantha L.
- Barnass Stella
- Barrett Nicholas
- Barrett Suzanne
- Bassford Christopher
- Basu Neil
- Basude Sneha
- Batra Rahul
- Baxter David
- Beadsworth Michael
- Benjamin Laura
- Bernatoniene Jolanta
- Berridge John
- Berry Colin
- Best Nicola
- Bethlehem Richard
- Blackledge Bethan
- Boardman Sarah A.
- Bogaert Debby
- Booth Laura
- Bothma Pieter
- Bradley John R.
- Bradley John R.
- Breen David P.
- Breen Gerome
- Breen Gerome
- Brennan Benjamin
- Breuer Judith
- Brittain-Long Robin
- Broome Matthew R.
- Bullmore Edward
- Bullock Katie
- Bulteel Naomi
- Burden Tom
- Burtenshaw Andrew
- Butler Matthew
- Carlucci Nicola
- Carracedo Alejandra D.
- Carson Alan
- Carson Gail
- Caruth Vikki
- Cass Emily
- Catterall Benjamin W.
- Cavanagh Jonathan
- Cavanagh Jonathan
- Chadwick David
- Chambler Duncan
- Chand Meera
- Chechi Kanta
- Chee Nigel
- Child Jenny
- Chinnery Patrick F.
- Chiollaz Anne-Cecile
- Christmas David
- Christmas David M.
- Chukkambotla Srikanth
- Clark Jordan J.
- Clark Jordan J.
- Clark Richard
- Clark Tom
- Clarke Emily A.
- Clohisey Sara
- Cole Sarah
- Coleman Jonathan R.
- Coles Alaisdair
- Coles Alasdair J.
- Collie Ceryce
- Collie Ceryce
- Collini Paul
- Connor Marie
- Cooke Graham S.
- Cooper Louise
- Cosgrove Catherine
- Cossette Nadine
- Cousins David
- Coutts Audrey
- Cox Helen
- Cupitt Jason
- Cutino-Moguel Maria-Teresa
- da Silva Ana
- Dalton Jo
- Darby Alastair
- Dark Paul
- David Anthony S.
- Davies Nicholas
- Davis Christopher
- Dawson Chris
- de Silva Thushan
- Defres Sylviane
- Dervisevic Samir
- Digby Richard
- Dincarslan Oslem
- Docherty Annemarie B.
- Dodd Katherine C.
- Donegan Cara
- Donnelly Lorna
- Donnison Phil
- Donohue Chloe
- dos Santos Gonçalo
- Douthwaite Sam
- Drake Thomas M.
- Dregan Alex
- Drummond Andrew
- Duff Eugene
- Dumas Marc-Emmanuel
- Dunai Cordelia
- Dunai Cordelia
- Dunn Chris
- Dunning Jake
- DuRand Ingrid
- Dushianthan Ahilanadan
- Dyer Philip
- Dyer Tristan
- Easton Ava
- Ebrahimi Soraya
- Egbe Franklyn N.
- Elliott Angela
- Ellul Mark A.
- Evangelou Nikos
- Evans Anthony
- Evans Cariad
- Eziefula Chi
- Facer Bethany
- Fairfield Cameron J.
- Fawkes Angie
- Fegan Chrisopher
- Fernandes Peter M.
- Finch Lorna
- Finn Adam
- Fisher Lewis W.
- Flaherty Lisa
- Fletcher Tom
- Foster Terry
- Fower Andrew
- Fox Hannah
- Francis Richard
- Fullerton Duncan
- Gamble Carrol
- Garcia-Dorival Isabel
- Garg Atul
- Garg Sanjeev
- Garjani Afagh
- George Lily
- Gilchrist Tammy
- Girvan Michelle
- Gkrania-Klotsas Effrossyni
- Glen Kiran
- Godden Jo
- Goldsmith Arthur
- Graham Clive
- Grammatikopoulos Tassos
- Green Christoper A.
- Greenhalf William
- Gregory Rebecca
- Griffin Julian L.
- Griffiths Fiona
- Griffiths Michael
- Griffiths Michael
- Grimbly Victoria
- Grundmann Alexander
- Grundmann Alexander
- Gunatilake Savini
- Gunning Philip
- Gupta Rishi K.
- Hafezi Katarzyna
- Halpin Sophie
- Hamid Shahd H.
- Hampshire Adam
- Hannah C.
- Hardwick Hayley
- Hardwick Marc
- Hardy Elaine
- Harris Jade D.
- Harrison Ewan
- Harrison Ewen M.
- Harrison Janet
- Harrison Neil
- Harrison Neil A.
- Harrison Paul J.
- Hartley Catherine
- Hartmann Monika
- Hartshorn Stuart
- Harvey Daniel
- Havalda Peter
- Hawcutt Daniel B.
- Held Marie
- Hendry Ross
- Hetherington Claire
- Hiscox Julian
- Hobrok Maria
- Hodel Eva M.
- Hodgson Luke
- Holden Karl
- Holland Angela E.
- Holmes Anthony
- Horby Peter W.
- Hormis Anil
- Hotopf Matthew
- Howard Joanne
- Huang Yun
- Hughes Stella
- Husain Masud
- Ijaz Samreen
- Irani Sarosh
- Irani Sarosh R.
- Jackson Clare
- Jackson Thomas
- Jacobs Michael
- Jain Susan
- Jenkins Thomas M.
- Jennings Paul
- Jensen Rebecca L.
- Jezzard Peter
- Jones Christopher B.
- Jones Trevor R.
- Kaliappan Agilan
- Kasipandian Vidya
- Keating Seán
- Kegg Stephen
- Keller Simon
- Kelsey Michael
- Kendall Jason
- Kerrison Caroline
- Kerslake Ian
- Khandaker Shadia
- Khoo Saye
- King Katharine
- Kingston Nathalie
- Kiy Robyn T.
- Klenerman Paul
- Knight Stephen R.
- Knight Susan
- Koch Oliver
- Koduri Gouri
- Koshy George
- Koukorava Chrysa
- Kyaw Sandar
- Laha Shondipon
- Lahnsteiner Eva
- Laird Steven
- Lake Annette
- Lant Suzannah
- Larkin Susan
- Latawiec Diane
- Lavelle-Langham Lara
- Law Andrew
- Lee James
- Leek Charles
- Leeming Gary
- Lefteri Daniella
- Leibowitz Maya
- Leiner Tamas
- Lett Lauren
- Lewis Gabriella
- Lewis Matthew R.
- Liggi Sonia
- Lilleker James B.
- Lillie Patrick
- Lim Wei S.
- Limb James
- Linnett Vanessa
- Little Jeff
- Livoti Lucia A.
- Lunn Michael P.
- Lyttle Mark
- MacGillivray Louise
- MacIver Claire L.
- Maclean Alan
- MacMahon Michael
- MacNaughton Emily
- Madarshahian Daniel
- Mancini Maria
- Mankregod Ravish
- Mansoori Parisa
- Marsh Laura
- Martin Naomi
- Maslen Lynn
- Massey Hannah
- Masson Huw
- Matovu Elijah
- Maziere Nicole
- McCafferty Sarah
- McCullough Katherine
- McDonald Sarah
- McDonald Sarah E.
- McDonnell Gavin
- McEvoy Laurence
- McEwen Ruth
- McGlinchey Emily
- McIlwaine Ryan
- McIntosh Andrew M.
- McLauchlan John
- Mclean Kenneth A.
- Meda Manjula
- Menon David K.
- Menon David K.
- Mentzer Alexander J.
- Merson Laura
- Metelmann Soeren
- Meynert Alison M.
- Miah Nahida S.
- Michael Benedict D.
- Michael Benedict D.
- Middleton Joanna
- Miller Karla
- Mills Gary
- Minton Jane
- Mitchell Joyce
- Mohandas Kavya
- Mok Quen
- Monssen Dina
- Moon James
- Moore Elinoor
- Moore Shona C.
- Morgan Patrick
- Morrice Kirstie
- Morris Christopher M.
- Morris Craig
- Mortimore Katherine
- Moses Samuel
- Mpenge Mbiye
- Mulholland Ciaran
- Mulla Rohinton
- Murphy Derek
- Murphy Ellen G.
- Murphy Lee
- Murphy Michael
- Nagarajan Thapas
- Nagel Megan
- Nair Akshay
- Needham Edward
- Needham Edward J.
- Nelson Mark
- Newcombe Virginia
- Nicholas Nathalie
- Nicholson Timothy
- Norman Lisa
- Norris Lillian
- Norris Lucy
- Norton Emma
- Noursadeghi Mahdad
- O'Malley Ronan
- O'Shea Matthew K.
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter J.
- Openshaw Peter J.
- Osagie Anthonia
- Ostermann Marlies
- Otahal Igor
- Paddick Stella-Maria
- Pais Mark
- Palmarini Massimo
- Palmieri Carlo
- Palmos Alish
- Palmos Alish
- Panchatsharam Selva
- Papakonstantinou Danai
- Papineni Padmasayee
- Paraiso Hassan
- Patel Arvind
- Patel Brij
- Pattison Natalie
- Paxton William A.
- Peacock Sharon
- Pendered Sophie
- Penrice-Randal Rebekah
- Pepperell Justin
- Peters Mark
- Phull Mandeep
- Pilgrim Jack
- Pintus Stefania
- Pius Riinu
- Planche Tim
- Plotkin Daniel
- Pollak Thomas
- Pollakis Georgios
- Pooni Jagtur S.
- Post Frank
- Price David
- Price Nicholas
- Prince Tessa
- Prout Rachel
- Rae Nikolas
- Rambaut Andrew
- Ren Alexander
- Reschreiter Henrik
- Reynolds Tim
- Reynolds Will
- Richardson Neil
- Ridley P. M.
- Roberts Angela
- Roberts Devender
- Roberts Mark
- Roberts Stephanie
- Robertson David L.
- Rogers Henry C.
- Rose Alistair
- Rota Silvia
- Rousseau Guy
- Ruge Bobby
- Russell Clark D.
- Ryan Brendan
- Sales Debby
- Salman Rustam A.
- Saluja Taranprit
- Samuel Merna
- Sanchez Jean-Charles
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Sargent Brendan
- Saviciute Egle
- Sawcer Stephen J.
- Schmid Matthias L.
- Scott Janet T.
- Scott-Brown James
- Seed Adam W.
- Semple Malcolm G.
- Semple Malcolm G.
- Semple Scott
- Shah Aarti
- Shankar-Hari Manu
- Shanmuga Prad
- Sharma Anil
- Sharma Parul
- Shaw Catherine A.
- Shaw Pamela J.
- Shaw Victoria
- Shaw Victoria E.
- Shawcross Anna
- Shears Rebecca K.
- Sieradzki Adam
- Sigfrid Louise
- Singh Bhagteshwar
- Sizer Jeremy
- Small Benjamin
- Smith Craig J.
- Smith Jacqueline
- Smith Richard
- Smith Stephen
- Snelson Catherine
- Solomon Tom
- Solomon Tom
- Spencer Rebecca G.
- Spittle Nick
- Sriskandan Shiranee
- Staines Nikki
- Stambach Tom
- Stewart James P.
- Stewart Richard
- Stirrups Kathy
- Stuart David
- Subramaniam Krishanthi
- Subramaniam Krishanthi S.
- Subudhi Pradeep
- Summers Charlotte
- Sunderland Geraint
- Swann Olivia V.
- Szakmany Tamas
- Szemiel Agnieska
- Taams Leonie
- Taams Leonie S.
- Taggart Aislynn
- Tait Sarah
- Takats Zoltan
- Takis Panteleimon
- Tamborska Arina
- Tanianis-Hughes Jolanta
- Tatham Kate
- Tato Esteban
- Taylor John-Paul
- Tedder Richard S.
- Tharmaratnam Kukatharmini
- Thomas Jo
- Thomas Jordan
- Thomas Rhys H.
- Thompson A. A. R.
- Thompson Chris
- Thompson Robert
- Thomson Emma
- Thomson Emma C.
- Thwaites Ryan S.
- Tonder Libby v.
- Tridente Ascanio
- Trochu Erwan
- Tupper-Carey Darell
- Turtle Lance C.
- Twagira Mary
- Underwood Jonathan
- Upthegrove Rachel
- Vallotton Nick
- van Daniel J.
- Vancheeswaran Rama
- Veenith Tonny
- Venneri Annalena
- Vincent Angela
- Vincent Angela
- Vincent Rachel
- Vincent-Smith Lisa
- Visuvanathan Shico
- Vuylsteke Alan
- Waddy Sam
- Wai Antonia Y.
- Wake Rachel
- Walden Andrew
- Welters Ingeborg
- Wham Murray
- Whitehouse Tony
- Whittaker Paul
- Whittington Ashley
- Wijesinghe Meme
- Wilcock Eve
- Williams Guy B.
- Williams Martin
- Williams Robyn
- Williams Steven
- Wilson Lawrence
- Winchester Stephen
- Wiselka Martin
- Wolverson Adam
- Wong Sui H.
- Wood Greta K.
- Wood Greta K.
- Wood Nicholas
- Wootton Daniel G.
- Workman Andrew
- Wrobel Nicola
- Yates Bryan
- Young Peter
- Zambon Maria
- Zandi Michael S.
- Zelaya Fernando
- Zhang J. E.
- Publication venue
- Nature Research
- Publication date
- 22/12/2023
- Field of study
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
- Author
- Aaronson Keith
- Abadier Rafik
- Abbasi Siddique A.
- Abdullah Shuaib
- Abelson Mark
- Abhayaratna Walter
- Ablasser Klemens
- Aboyans Victor
- Abo‐Auda Wael
- Abuannadi Mohammad
- Adams Kirkwood
- Adams Kirkwood F.
- Adhya Shaumik
- Adler Alexander
- Aggarwala Gaurav
- Agostoni Piergiuseppe
- Ahmad Saad
- Aiub Jorge Roberto
- Al Mohammad Abdallah
- Alharethi Rami
- Alieksieieva Liudmyla
- Almeida Filipa
- Almousalli Omar
- Amano Tetsuya
- Amanullah Aman
- Ambardekar Amrut
- Amerena John
- Anand Inder
- Anderson William
- Ando Kenji
- Andreka Peter
- Antalik Lubomir
- Aradi Daniel
- Araiza Raul Reyes
- Arbolishvili Georgy
- Ariani Mehrdad
- Arias‐Mendoza Alexandra
- Arora Raveen
- Arroyo Julian Alonso Coronel
- Artis Andre
- Asakura Masanori
- Asano Hiroshi
- Ashcom Thomas
- Aslam Shamaila
- Asubiaro Joshua
- Atherton John
- Avaca Horacio Alberto
- Babapulle Mohan
- Bacal Fernando
- Badak Ozer
- Badariene Jolita
- Badat Aysha
- Baker Mathue
- Balsam Pawel
- Banerji Sourin
- Barbarash Olga
- Barbetseas Ioannis
- Barr Craig
- Barros e Silva Pedro Gabriel Melo
- Barua Rajat
- Bauerlein Eugene Joseph
- Baweja Paramdeep
- Bednarkiewicz Zbigniew
- Beelen Driek
- Begg Alistair
- Bekar Lutfu
- Belenkiy Dmitriy
- Belohlavek Jan
- Beltrame John
- Berdague Philippe
- Berglund Stefan
- Berk Martin
- Berkowski Piotr
- Berra Fernando Colombo
- Bertolet Barry
- Besada Diego Alejandro
- Beug Daniel
- Bezzegh Katalin
- Bhagwat Ravi
- Bhargava Rakesh
- Biering‐Sørensen Tor
- Bilato Claudio
- Blicharski Tomasz
- Boccalandro Fernando
- Boehm Michael
- Boehmer John
- Bogaev Roberta
- Bolshakova Olga
- Boman Kurt
- Bonderman Diana
- Bonet Luis Almenar
- Bonfanti Alberto Cadena
- Bordonava Anselmo Paulino
- Bostick Brian
- Boswijk Dirk
- Bourgeois Ronald
- Bourhaial Hakima
- Bouza Manuel
- Braga Joao Carlos
- Brasca Daniela Garcia
- Brinkley Douglas
- Brito Dulce
- Brunetti Natale Daniele
- Bruno Marco Raul Litvak
- Bu Peili
- Burgess Lesley
- Busak Ladislav
- Buynak Robert
- Buysschaert Ian
- Bykov Alexander
- Böhm Michael
- Caccavo Alberto
- Canesin Manoel
- Cardona Jose
- Cardoso Juliano
- Carluccio Erberto
- Carrasco Jose Alfredo Pagola
- Carson Peter
- Castillo Armando Garcia
- Cavallini Claudio
- Cavusoglu Yuksel
- Cech Vladimir
- Celik Ahmet
- Celutkiene Jelena
- Cepelak Michal
- Cerci Rodrigo Julio
- Chandra Lokesh
- Chandrasekaran Badrinathan
- Chang David
- Chaves Renato
- Chehayeb Raja
- Cheirif Jorge
- Chen Guoqin
- Chen Jiyan
- Chmielak Zbigniew
- Chouchane Iman
- Chung Eugene
- Cid Maria Cristina Schnettler
- Civitello Andrew
- Clark Andrew
- Cleland John G.F.
- Clifford Piers
- Coletti Andrew
- Collins John
- Colque Roberto
- Constance Christian
- Contreras Johanna
- Corbalan Ramon
- Corbalan Ramon
- Correa Luis Eduardo Echeverria
- Corredor Miguel Alfredo Moncada
- Cosansu Kahraman
- Costa‐Vitali Atilio
- Cotarlan Vladimir
- Coufal Zdenek
- Cox Jeremy
- Crespo‐Leiro Maria G.
- Cruz Kimberly
- Cubero Javier Segovia
- Cui Hanbin
- Cymerman Krzysztof
- Dahlström Ulf
- Damy Thibaud
- Dauber Ira
- De Geeter Guillaume
- De los Rios Ibarra Manuel Odin
- De Pasquale Carmine
- Decoulx Eric
- Demir Mesut
- Desai Pratik
- Diaz Rafael
- Diaz Rafael
- Diaz Victor Alfonso Jimenez
- Dib Nabil
- Diez Mirta
- Dimov Bojidar
- Doblas Juan Jose Gomez
- Doi Masayuki
- Domae Hiroshi
- Donal Erwan
- Dong Yugang
- Donnelly Patrick
- Dorobantu Maria
- Dovgolis Svetlana
- Doyle Timothy
- Drexel Heinz
- Dronov Dmitry
- Droogne Walter
- Drozdz Jaroslaw
- Duarte Tatiana
- Duengen Hans‐Dirk
- Dujardin Karl
- Dupont Matthias
- Duran Ruben Omar Garcia
- Duzenli Mehmet
- Dzupina Andrej
- Eaton Charles
- Ebato Mio
- Ebelt Henning
- Eberly Arthur
- Ebner Christian
- Echeverria Correa Luis E.
- Elliott James
- Elmahi Einas
- Elvan Arif
- Esperon Guillermo Antonio Llamas
- Ezekowitz Justin
- Ezhov Marat
- Fang James
- Fang James C.
- Farris Neil
- Feitell Scott
- Felker G. Michael
- Fernandez Alberto
- Fernando Ronald
- Ferraz Almir
- Figal Domingo Andres Pascual
- Filho Otavio Coelho
- Filho Pedro Pimentel
- Filippatos Gerasimos
- Fisher Daniel
- Florea Viorel
- Flores Ana Maria De Leon
- Floresta Agata Marina
- Fonseca Candida
- Fonseca Cândida
- Forman Steven
- Forster Tamas
- Fortes Jose Augusto Ribas
- Fourie Nyda
- Franchi Francesco
- Frank Theodore
- Frankenstein Lutz
- Freire Ramon Bover
- Fremont Richard
- French John
- Friedman Keith
- Frigerio Maria
- Friz Hernan Emilio Francisco Polo
- Fu Xin
- Fucili Alessandro
- Fuente Galan Luis
- Fuente Ricardo Alfonso Leon
- Fujii Kenshi
- Fujii Shigeru
- Fujiwara Wakaya
- Fukuzawa Shigeru
- Fulop Peter
- Gabriel George
- Gajardo Victor Areli Saavedra
- Galinier Michel
- Ganeshram Vedampattu
- Ganji Jagadeesh
- Garrido Marcelo Alejandro
- Gass Alan
- Gaudet Daniel
- Geltman Edward
- Gemignani Anthony
- Genth‐Zotz Sabine
- Georges Jean‐Louis
- Giamouzis Grigorios
- Gianfagna Robert
- Giannetti Nadia
- Gilmore Richard
- Giorgeto Flavio Eduardo
- Giraldo Clara Ines Saldarriaga
- Giuca Alina
- Giudici Vittorio
- Glover Jason
- Gogia Harinder
- Gohara Seiichiro
- Gola Zbigniew
- Goloshchekin Boris
- Goncalvesova Eva
- Goncalvesova Eva
- Goncharov Ivan
- Gonsorcik Jozef
- Gonzalez Ricardo Garcia
- Gonzalez Salvador Leon
- Gordon Brian
- Gorodeski Eiran
- Gottlieb Stephen
- Goudev Assen
- Goudev Assen R.
- Gray Wayne
- Grazette Luanda
- Greco Oswaldo
- Grewal Gurinder
- Groote Pascal De
- Gueffet Jean‐Pierre
- Guerrero Rodolfo Andres Ahuad
- Gupta Dinesh
- Gupta Milan
- Guray Umit
- Haddad Tariq
- Haehling Stephan
- Hajko Erik
- Hal John
- Halpern Stephen
- Hametz Craig
- Hamilton Andrew
- Han Qinghua
- Han Yajun
- Handel Franklin
- Hara Hisao
- Harris John
- Hart Hamish
- Hart Terence
- Hartleib Michael
- Hasni Syed
- Hata Yoshiki
- Hattler Brack
- Hearne Steven
- Hedgepeth Chester
- Heilman Karl
- Heitner John
- Henderson David
- Herczeg Bela
- Hermans Walter
- Herzog William
- Hidaka Takayuki
- Hidalgo Mario Yanez
- Higashino Yorihiko
- Hiroi Shitoshi
- Hominal Miguel Angel
- Horacek Thomas
- Houra Marek
- Houston Brian
- Howlett Jonathan G.
- Huang He
- Huber Kurt
- Huelsmann Martin
- Hullin Roger
- Hunter Vernon
- Huynh Thao
- Ibañez Julio
- Ibrahim Hassan
- Indolfi Ciro
- Inomata Takayuki
- Iseki Harukazu
- Ishikawa Masahiro
- Isnard Richard
- Isshiki Takaaki
- Itchhaporia Dipti
- Ito Hiroshi
- Jackson Bruce
- Jacob Binu
- Jadbabaie Farid
- Jaeger Cristiano Pederneiras
- Jaffrani Naseem
- Jalaf Margarita Gertrudis Vejar
- Janik Matthew
- Jankowski Piotr
- Janmohamed Munir
- Jarasuniene Dalia
- Jattin Fernando Manzur
- Javier Julian
- Jeppesen Jorgen
- Jerabek Ondrej
- Jimenez Juan Francisco Delgado
- Jofre Christian Paolo Pincetti
- Jondeau Guillaume
- Jones Alonzo
- Joseph Susan
- Juanatey Jose Ramon Gonzalez
- Judkins Christopher
- Kadel Christoph
- Kadokami Toshiaki
- Kafara Mariusz
- Kai Hisashi
- Kaiser‐Nielsen Peter
- Kajinami Kouji
- Kalarus Zbigniew
- Kalecinska‐Krystkiewicz Ewa
- Kalra Paul
- Kaluski Edo
- Kanda Junji
- Kania Grzegorz
- Kao John
- Karavidas Apostolos
- Karim Amin
- Karlstrom Patric
- Karpenko Oleksandr
- Karvounis Haralambos
- Kasai Toshio
- Kassiotis Christos
- Katz Richard
- Kawakami Hideo
- Kawamitsu Katsunori
- Kawasaki Tomohiro
- Kazemi Navid
- Kazinczy Rita
- Kearney Leighton
- Keeling Philip
- Kellnerova Ivana
- Khalife Wissam
- Kida Keisuke
- Killat Holger
- Kindel Carlos Conejeros
- King Anthony
- Kirma Cevat
- Kitaoka Hiroaki
- Klimsa Zdenek
- Klug Eric
- Kobalava Zhanna
- Kochiadakis George
- Koga Tokushi
- Koike Akihiro
- Koizumi Tomomi
- Koldas Zehra Lale
- Koleckar Pavel
- Komiyama Nobuyuki
- Kondo Nicholas
- Konieczynska Malgorzata
- Kono Alan
- Koo Charles
- Kopaczewski Jerzy
- Korczyk Dariusz
- Koren Michael
- Korzh Oleksii
- Kosmacheva Elena
- Kostenko Viktor
- Kotelnikov Mikhail
- Kowalski Robert
- Kracz Igor
- Krantz Mori
- Krishnamoorthy Arun
- Krupicka Jiri
- Kryza Radim
- Kubota Toru
- Kulibaba Elena
- Kulynych Oleksii
- Kurtz Christopher E.
- Kwan Michael
- Lader Ellis
- Lakatos Ferenc
- Lakshminarayanan Batlagundu
- Lancellotti Patrizio
- Lanfear David E.
- Lang Chim
- Lang Christopher
- Laperche Thierry
- Laszlo Zoltan
- Leaes Paulo Ernesto
- Lefebvre Jean‐Marie
- Legg Jason C.
- Leiro Maria Generosa Crespo
- Lelonek Malgorzata
- Lenartowska Lucyna
- Lenner Egon
- Leon Jose Luis Arenas
- Leonardi Sergio
- Lepor Norman
- LeWinter Martin
- Lewis Neil
- Li Dongye
- Li Jianjun
- Li Tianfa
- Li Weimin
- Li Yinjun
- Li Zhangquan
- Li Zhaoping
- Lighezan Daniel
- Lindholm Carl‐Johan
- Linssen Gerardus
- Liu Feng
- Llamas Edmundo Alfredo Bayram
- Llerena Sara
- Lohr Nicole
- Londono Juan
- Lopez Gabriel Arturo Ramos
- Lopez Luis Horacio Atehortua
- Lopez Rodrigo Botero
- Lovell Charles
- Ludman Andrew
- Luengas Carlos Alberto
- Lukacova Jana
- Lukyanov Yury
- Lund Marianne
- Lund Mayanna
- Lupkovics Geza
- Lupovitch Steven
- Luquez Hugo
- Lymar Yurii
- Lynch Mary
- Ma Shumei
- Macarie Cezar‐Eugen
- Macdonald Peter
- Macdonald Peter
- Machado Gustavo Francisco Mendez
- Machova Vilma
- Macias Leonardo
- Mackinnon Ignacio
- Maejima Yasuhiro
- Magro Michael
- Mahemuti Ailiman
- Mahmood Shahid
- Maia Lilia Nigro
- Majercak Ivan
- Majul Claudio Rodolfo
- Malhotra Sanjay
- Malhotra Vinay
- Malik Adnan
- Malik Fady I.
- Mamdani Shafiq
- Mancini Donna
- Manenti Euler Roberto Fernandes
- Manita Mamoru
- Manolis Athanasios
- Mantas Ioannis
- Mareev Vyacheslav
- Mareev Vyacheslav
- Margoczy Roman
- Margonato Alberto
- Mark Laszlo
- Marquez Lilia Luz Lobo
- Martindale Jeffrey
- Martinez Diego Felipe
- Martinez Laura Jordan
- Martinez Luis
- Martinez‐Arraras Joaquin
- Martinez‐Castrillon Melvin
- Marzouka George
- Masuda Seigo
- Matsumoto Takashi
- Mayer Nolan
- Mayoral Alejandro Recio
- McGrew Frank
- McKelvie Robert
- McKenzie Scott
- McLean Dalton
- McMurray John J.V.
- Menck Niels
- Mendoza Jose Luis Accini
- Mendoza Maria Alexandra Arias
- Merkely Bela
- Metra Marco
- Metra Marco
- Meyer Philippe
- Mi Yafei
- Michishita Ichiro
- Miekus Pawel
- Mielniczuk Lisa
- Mignone John
- Militaru Constantin
- Mincheva Valentina
- Mishchenko Larysa
- Mitrokhin Vladislav
- Mitrovic Veselin
- Mitsuo Kazuhisa
- Mittag Marcus
- Mitu Florin
- Miura Shinichiro
- Miyamoto Michael
- Miyamoto Nobuhide
- Miyazaki Tetsuro
- Moccetti Tiziano
- Mody Freny
- Moe Gordon
- Moertl Deddo
- Mohacsi Attila
- Mohapatra Robert
- Molina Beatriz Diaz
- Momiyama Yukihiko
- Momomura Shin‐ichi
- Monhart Zdenek
- Montana Oscar Romano
- Monteiro Pedro
- Moodley Rajendran
- Mori Masuki
- Morita Yukiko
- Morrow John Andrew
- Mortara Andrea
- Mostovoy Yuriy
- Motovska Zuzana
- Motylev Igor
- Mouhaffel Asad
- Muderrisoglu Ibrahim Haldun
- Mueller Christian
- Murray David
- Muthumala Amal
- Myasnikov Roman
- Nadar Venkatesh
- Nagy Laszlo
- Nair Nandini
- Naka Katerina
- Nakamura Akihiro
- Nakamura Kentaro
- Nalbantgil Sanem
- Nechvatal Libor
- Nelson William
- Nessler Jadwiga
- Nguyen Viviane
- Nicolosi Liliana
- Nielsen Tonny
- Niu Wentang
- Node Koichi
- Noll Georg
- Nosov Vladimir
- Novaretto Leonardo
- Numaguchi Kotaro
- Nyolczas Noemi
- Nyvad Ole
- O'Brien Terrence
- O'Meara Eileen
- O'Meara Eileen
- Ogawa Tomohiro
- Oishi Shogo
- Okishige Kaoru
- Okumura Takahiro
- Okumura Yasuo
- Okuyan Ertugrul
- Oliveira Soares Manue Martinez‐Selles D
- Oliveira Luis
- Olsen Stephanie
- Onoue Kenji
- Onrat Ersel
- Ooi Henry
- Orgera Marisa
- Ortiz Aurelio
- Osipova Irina
- Osorio Wilder Castaño
- Ovize Michel
- Padron Antonio Lara
- Paiva Maria Sanali
- Palomas Juan Luis Bonilla
- Pandey A Shekhar
- Paolino Bruno
- Papp Andras
- Papp Aniko
- Pareja Monica Lopez
- Parissis John
- Parkhomenko Alexander
- Parkhomenko Oleksandr
- Parody Maria Leonor
- Paszczuk Anna
- Patel Devesh
- Patsilinakos Sotirios
- Pauwaa Sunil
- Pawlowicz Lidia
- Paya Vicente Eduardo Climent
- Peart Brenda
- Peiro Maria Teresa Blasco
- Pelaez Sebastian Velez
- Perez Sonia Mirabet
- Perna Eduardo
- Perna Gianpiero
- Pesant Yves
- Peterka Karel
- Peterson Magnus
- Petrov Ivo
- Pfister Roman
- Pham Michael
- Phaneuf Denis‐Carl
- Pianko Leonard
- Piatek Marek
- Picard François
- Pickett Christopher
- Piegas Leopoldo Soares
- Pijanowski Zbigniew
- Pillutla Priya
- Pimenov Leonid
- Pini Daniela
- Piovaccari Giancarlo
- Pisani Barbara
- Podoleanu Cristian Gheorghe
- Podpera Ivo
- Poelzl Gerhard
- Polasek Rostislav
- Ponikowski Piotr
- Popescu Mircea Ioachim
- Portnay Edward
- Postadzhiyan Arman
- Potthoff Sergio
- Poy Carlos
- Pozdisek Zbynek
- Prado Aldo
- Prado Jose Maria Arizon
- Price Dallas
- Prokhorov Oleksandr
- Proulx Guy
- Qu Yanling
- Radin Michael
- Radojevic Joseph
- Rafalskiy Vladimir
- Rahko Peter
- Rajagopalan Navin
- Rama Bhola
- Ramanathan Kodangudi
- Ramires Felix
- Ramires Felix J. A.
- Ramos Mark
- Ranadive Nandkishore
- Randall William
- Rao Sunder
- Rasmussen Mariela
- Rasputina Lesya
- Rassaf Tienush
- Rassi Salvador
- Rawitscher David
- Reis Gilmar
- Remmen Johannes
- Rennyson Stephen
- Repin Alexey
- Ricci Jean Etienne
- Rider James
- Rishko Mykola
- Rivero Mariel
- Robinson Shawn
- Rodriguez Alicia Contreras
- Rojas Pastor Olaya
- Rosamel Yann
- Rossi Paulo Roberto Ferreira
- Rossini Roberta
- Roth Sherryn
- Roubille Francois
- Rowan Christopher
- Roy Debashis
- Rudenko Leonid
- Rudyk Iurii
- Ruiz Alberto Esteban Bazzoni
- Rupka Dennis
- Ryabov Vyacheslav
- Ryding Alisdair
- Rynkiewicz Andrzej
- Römer Tjeerd
- Sabatier Rémi
- Sahin Tayfun
- Sakagami Satoru
- Sakai Tetsuo
- Sakamoto Tomohiro
- Sakata Yasushi
- Salamon Csaba
- Salazar Dora Ines Molina
- Salazar Melchor Alpizar
- Salomone Oscar Alejandro
- Salukhov Vladimir
- Salvat Muriel
- Sampognaro Gregory
- Sandri Marcus
- Santos Luis
- Saraiva Jose Francisco
- Sarmento Pedro Morais
- Sassone Sonia
- Sato Yukihito
- Sauer Andrew
- Savard Daniel
- Sawyer Douglas
- Saxena Sanjeev
- Schaap Jeroen
- Schee Alexandr
- Schiavi Lilia
- Schmalfuss Carsten
- Schnitzler Robert
- Schultz David
- Sciborski Ryszard
- Scott Russell
- Segarra Jorge Leonardo Cobos
- Semenova Irina
- Senaratne Manohara
- Senni Michele
- Sepulveda Alex Mauricio Villablanca
- Serikawa Takeshi
- Serpytis Pranas
- Serpytis Pranas
- Seto Arnold
- Shah Amit
- Shah Anil
- Shah Keyur
- Shah Nishant
- Shandling Adrian
- Sharma Mukesh
- Sharpsten Lucie
- Shayani Steven
- Sherenkov Alexander
- Shilkina Nataliya
- Shimizu Wataru
- Shimomura Mitsuhiro
- Shin Jooyoung
- Shutemova Elena
- Shvarts Yury
- Sichrovsky Tina
- Sidor Mateusz
- Silva Neto Luis Beck
- Silva Rodrigo
- Silveira Fabio
- Simoes Marcus Vinicius
- Simon Marc
- Sinagra Gianfranco
- Sindone Andrew
- Singh Deovrat
- Singh Pradeep
- Siostrzonek Peter
- Sitnikova Maria
- Skaria Binoy
- Skonieczny Grzegorz
- Skopicki Hal
- Skrobakova Janka
- Slapikas Rimvydas
- Sliwa Karen
- Sluis Aize
- Smart Frank
- Smik Rudolf
- Smilde Tom
- Sobkowicz Bozena
- Sochor Karel
- Sokos George
- Solomon Scott D.
- Solovev Oleg
- Souza Weimar Kunz Barroso
- Spacek Rudolf
- Spinar Jindrich
- Spinar Jindrich
- Spinarova Lenka
- Spiridon Marilena Renata
- Spyra Janusz
- Stahl Llyod
- Stamate Sorin
- Stanciulescu Gabriela
- Stanislavchuk Mykola
- Stankiewicz Anna
- Starling Randall
- Stepek David
- Stets Roman
- Stevlik Jan
- Stewart Robert
- Stoddard Marcus
- Straburzynska‐Migaj Ewa
- Strader J Russell
- Styliadis Ioannis
- Störk Stefan
- Sugino Hiroshi
- Sulemanjee Nasir
- Sun Yuemin
- Sussex Bruce
- Suter Thomas
- Suter Thomas M.
- Suzuki Masahiro
- Sverdlov Aaron
- Sweitzer Nancy
- Szabo Barna
- Szakal Imre
- Szasz Gyula
- Szczasny Marcin
- Szto Gregory
- Taggeselle Jens
- Tahirkheli Naeem
- Takagi Atsutoshi
- Takahashi Natsuki
- Takaishi Hiroshi
- Takama Noriaki
- Takata Theodore
- Takeishi Yasuchika
- Takenaka Takashi
- Tallet Julio
- Tanabe Jun
- Tanaka Takahiro
- Tang Huifang
- Tarasov Nikolay
- Tartiere Jean‐Michel
- Tatebe Shunsuke
- Taylor Justin
- Teerlink John R.
- Terasaki Toshiro
- Terasawa Akihiro
- Tereschenko Sergey
- Timofeev Alexander
- Tisheva‐ Gospodinova Snezhanka
- Tocchetti Carlo Gabriele
- Todorov Georgi
- Tognon Alexandre
- Tomcsanyi Janos
- Tomcsanyi Janos
- Toth Kalman
- Treasure Charles
- Trebacz Jaroslaw
- Trevelyan Jasper
- Triana Miguel Urina
- Trichon Benjamin
- Trochu Jean Noel
- Tsabedze Nqoba
- Tsao Lana
- Tseluyko Vira
- Tsioufis Konstantinos
- Tsujimoto Mitsuru
- Tuncer Mustafa
- Turgut Okan Onur
- Tyl Petr
- Tzekova Maria
- Tziakas Dimitrios
- Ueda Yasunori
- Ueno Hideki
- Uhliar Rudolf
- Ujino Keiji
- Uretsky Barry
- Usui Makoto
- Utsu Noriaki
- Vaccari Christopher
- Vakaliuk Igor
- Van Eck Jacob
- Van Kesteren Henricus
- Van Zyl Louis
- Vandekerckhove Hans
- Vandekerckhove Hans
- Vanhecke Thomas
- Varin Claire
- Vasallo Javier
- Vasilev Ivaylo
- Vasilyeva Larysa
- Vaz Garth
- Vazquez Eduardo Salcido
- Vega Mario
- Velikov Chavdar
- Venegas Manuel Eduardo Rodriguez
- Videbaek Lars
- Vidotti Maria Helena
- Vijay Nampalli
- Vilamajo Oscar Alberto Gomez
- Vilchez Francisco Gonzalez
- Villani Giovanni Quinto
- Villoch Mario
- Villota Julio Eduardo Nuñez
- Vinanska Daniela
- Vincenzi Antonella
- Vinereanu Dragos
- Vinereanu Dragos
- Vishnevsky Alexander
- Voevoda Mikhail
- Vogel Daniel
- Voicu Olga‐Cristina
- Volterrani Maurizio
- Voors Adriaan
- Voors Adriaan A.
- Voronkov Leonid
- Vraa Soren
- Wada Atsuyuki
- Wahid Faisal
- Wal Ruud
- Wang Yi
- Wang Zhifang
- Watanabe Naoki
- Wei Yu
- Weir Robin
- Westenfeld Ralf
- Wheeler Matthew
- Whellan David
- Wiggers Henrik
- Wilkett Matt
- Willems Frank
- Williams Celeste
- Wlodarczyk Aleksander
- Wodlin Peter
- Wong Kenneth
- Wozakowska‐Kaplon Beata
- Wu Weiheng
- Yagensky Andriy
- Yamamoto Mitsutaka
- Yan Jing
- Yang Ping
- Yang Xuming
- Yang Zhenyu
- Yeoman Gary
- Yigit Zerrin
- Yilmaz Mehmet B.
- Yoshida Takeshi
- Yoshikawa Masaki
- Yousuf Kabir
- Yuan Zuyi
- Yuge Masaru
- Zabowka Maciej
- Zaca Valerio
- Zaidman Cesar
- Zanetti Fernando Tomas Lanas
- Zannad Faiez
- Zapata Gerardo
- Zdrenghea Dumitru
- Zeman Kamil
- Zeymer Uwe
- Zhang Jinguo
- Zhang Lily
- Zhang Shouyan
- Zhang Xuelian
- Zhang Yuhui
- Zhang Yuqing
- Zheng Yang
- Zheng Zhe
- Zhou Changyong
- Zieroth Shelley
- Zilahi Zsolt
- Zimmet Hendrik
- Zolty Ronald
- Zrazhevskiy Konstantin
- Zwaan Coenraad
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594).
Conclusions:
GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Extended tuning of distributed-feedback lasers in a bias-tee circuit via waveform optimization for MHz-rate absorption spectroscopy
- Author
- Publication venue
- IOP Publishing
- Publication date
- 21/06/2022
- Field of study
International audienceVariations in injection-current waveform are examined using diplexed RF-modulation with continuouswave distributed-feedback (CW-DFB) lasers, with the aim to maximize the spectral tuning range and signal-tonoise ratio for MHz-rate laser absorption spectroscopy. Utilizing a bias-tee circuit, laser chirp rates are shown to increase by modulating the AC input voltage using square waves instead of sine waves and by scanning the laser below the lasing threshold during the modulation period. The effect of waveform duty cycle and leadingedge ramp rate are further examined. A spectral scan depth on the order of 1 cm −1 at a scan frequency of 1 MHz is achieved with a representative CW-DFB quantum cascade laser near 5 µm. Distortion of high-frequency optical signals due to detector bandwidth is also examined, and limitations are noted for applications with narrow spectral features and low-bandwidth detectors. Based on common detection system limitations, an optimization approach is established for a given detection bandwidth and target spectra. A representative optimization is presented for measurements of sub-atmospheric carbon monoxide spectra with a 200-MHz detection system. The methods are then demonstrated to resolve transient gas properties (pressure and temperature) via laser absorption spectroscopy at MHz rates in a detonation tube and shock tube facility. An appendix detailing a first-order model of high-speed distributed feedback laser tuning dynamics is also included to support the experimental observations of this work
Multi-gene testing in neurological disorders showed an improved diagnostic yield: data from over 1000 Indian patients
- Author
- Agrawal Pooja
- Aswathy S L
- Chandru Vijay
- Chinnappa Swathi M
- Devi A Radha Rama
- Ganapathy Aparna
- George Sobha
- Gowda Vykuntaraju K
- Hariharanu Ramesh
- Hasan Qurratulain
- Hegde Anaita Udwadia
- Kamate Mahesh
- Kanthi Anil Vittal
- Katragadda Shanmukh
- Kumar M. Pradeep
- Kumar Priyanka
- Kunju P A Mohammed
- Manna Ashraf U
- Menon Ramshekhar N
- Mishra Avshesh
- Naik Neeta
- Nair Mohandas
- Nampoothiri Sheela
- Nayanala Swetha
- Pachat Divya
- Parulekar Minothi
- Patric Irene Rosetta Pia
- Prakash Manasa B
- Puri Ratna D
- Raghavendrachar Vijayashree G
- Sadagopan Mukunth
- Shah Krati
- Sheth Frenny
- Sheth Jayesh
- Soni Megha Rani
- Sridharan Aparajit
- Sundaram Soumya
- Thyagarajan T C
- Tilak Preetha
- Udani Vrajesh
- Veeramachaneni Vamsi
- Vidya H K
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- Field of study
Background Neurological disorders are clinically heterogeneous group of disorders and are major causes of disability and death. Several of these disorders are caused due to genetic aberration. A precise and confirmatory diagnosis in the patients in a timely manner is essential for appropriate therapeutic and management strategies. Due to the complexity of the clinical presentations across various neurological disorders, arriving at an accurate diagnosis remains a challenge. Methods We sequenced 1012 unrelated patients from India with suspected neurological disorders, using TruSight One panel. Genetic variations were identified using the Strand NGS software and interpreted using the StrandOmics platform. Results We were able to detect mutations in 197 genes in 405 (40%) cases and 178 mutations were novel. The highest diagnostic rate was observed among patients with muscular dystrophy (64%) followed by leukodystrophy and ataxia (43%, each). In our cohort, 26% of the patients who received definitive diagnosis were primarily referred with complex neurological phenotypes with no suggestive diagnosis. In terms of mutations types, 62.8% were truncating and in addition, 13.4% were structural variants, which are also likely to cause loss of function. Conclusion In our study, we observed an improved performance of multi-gene panel testing, with an overall diagnostic yield of 40%. Furthermore, we show that NGS (next-generation sequencing)-based testing is comprehensive and can detect all types of variants including structural variants. It can be considered as a single-platform genetic test for neurological disorders that can provide a swift and definitive diagnosis in a cost-effective manner
Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure
- Author
- A Alan Chu
- A Shekhar Pandey
- Aaron Sverdlov
- Abbasi S. A.
- Abdallah Al Mohammad
- Abdul Al-Hesayen
- Adams K. F.
- Adnan Malik
- Adriaan Voors
- Adrian Shandling
- Agata Marina Floresta
- Ahmet Celik
- Ailiman Mahemuti
- Aize van der Sluis
- Akihiro Koike
- Akihiro Nakamura
- Akihiro Terasawa
- Alan Gass
- Alan Kono
- Alan Meholick
- Alberto Caccavo
- Alberto Cadena Bonfanti
- Alberto Esteban Bazzoni Ruiz
- Alberto Fernandez
- Alberto Margonato
- Aldo Prado
- Alejandro Recio Mayoral
- Aleksander Wlodarczyk
- Aleksandra Manolova
- Alessandro Fucili
- Alex Mauricio Villablanca Sepulveda
- Alexander Adler
- Alexander Bykov
- Alexander Parkhomenko
- Alexander Sherenkov
- Alexander Timofeev
- Alexander Vishnevsky
- Alexandr Schee
- Alexandra Arias Mendoza
- Alexandre Tognon
- Alexey Repin
- Alicia Contreras Rodriguez
- Alina Giuca
- Alisdair Ryding
- Alistair Begg
- Almir Ferraz
- Alonzo Jones
- Amal Muthumala
- Aman Amanullah
- Amarinder Bindra
- Amin Karim
- Amin Yehya
- Amit Shah
- Amrut Ambardekar
- Ana Maria De Leon Flores
- Anand I.
- Anays Santana Izquierdo
- Andras Papp
- Andre Artis
- Andrea Mortara
- Andrej Dzupina
- Andres Iñiguez Romo
- Andrew Boyle
- Andrew Civitello
- Andrew Clark
- Andrew Coletti
- Andrew Hamilton
- Andrew Ludman
- Andrew Sauer
- Andrew Sindone
- Andriy Yagensky
- Andrzej Rynkiewicz
- Aniko Papp
- Anil Shah
- Anna Paszczuk
- Anna Stankiewicz
- Anselmo Paulino Bordonava
- Anthony Gemignani
- Anthony King
- Antonella Vincenzi
- Antonio Juan Castro Fernandez
- Antonio Lara Padron
- Apostolos Karavidas
- Arias-Mendoza A.
- Arif Elvan
- Arman Postadzhiyan
- Armando Garcia Castillo
- Arnold Seto
- Arthur Eberly 3rd
- Arun Krishnamoorthy
- Arunima Misra
- Assad Mouhaffel
- Assen Goudev
- Athanasios Manolis
- Atilio Costa-Vitali
- Atsushi Hirayama
- Atsutoshi Takagi
- Atsuyuki Wada
- Attila Mohacsi
- Aurelio Ortiz
- Aysha Badat
- Badrinathan Chandrasekaran
- Balgit Chhokar
- Barbara Pisani
- Barna Szabo
- Barry Bertolet
- Barry H Greenberg
- Barry Uretsky
- Batlagundu Lakshminarayanan
- Beat Knusel
- Beata Wozakowska-Kaplon
- Beatriz Diaz Molina
- Bela Herczeg
- Bela Merkely
- Benjamin Trichon
- Bhola Rama
- Biering-Sorensen T.
- Binoy Skaria
- Binu Jacob
- Bohm M.
- Bojidar Dimov
- Bonderman D.
- Boris Goloshchekin
- Bozena Sobkowicz
- Brack Hattler
- Bradley Weinberg
- Brenda Lemus
- Brenda Peart
- Brian Bostick
- Brian Claggett
- Brian Gordon
- Brian Houston
- Bruce Jackson
- Bruce Sussex
- Bruno Paolino
- Candida Fonseca
- Carl-Johan Lindholm
- Carlo Gabriele Tocchetti
- Carlos Alberto Luengas
- Carlos Arrieta Garcia
- Carlos Conejeros Kindel
- Carlos Poy
- Carmine De Pasquale
- Carol Davila
- Carsten Schmalfuss
- Celeste Williams
- Cesar Zaidman
- Cevat Kirma
- CezarEugen Macarie
- Changyong Zhou
- Charles Eaton
- Charles Koo
- Charles Lovell
- Charles Treasure
- Chavdar Velikov
- Chester Hedgepeth
- Chiara Melloni
- Chim Lang
- Christian Constance
- Christian Ebner
- Christian Mueller
- Christian Paolo Pincetti Jofre
- Christoph Kadel
- Christopher E Kurtz
- Christopher Judkins
- Christopher Lang
- Christopher Pickett
- Christopher Rowan
- Christopher Vaccari
- Christos Kassiotis
- Ciro Indolfi
- Claire Varin
- Clara Ines Saldarriaga Giraldo
- Claudia Raineri
- Claudio Bilato
- Claudio Cavallini
- Claudio Rodolfo Majul
- Cleland J. G. F.
- Coenraad van der Zwaan
- Constantin Militaru
- Corbalan R.
- Craig Barr
- Craig Hametz
- Crespo-Leiro M. G.
- Cristian Gheorghe Podoleanu
- Cristiano Pederneiras Jaeger
- Cristina Danila
- Csaba Salamon
- Dahlstrom U.
- Dalia Jarasuniene
- Dallas Price
- Dalton McLean
- Daniel Aradi
- Daniel Beug
- Daniel Fisher
- Daniel Gaudet
- Daniel Lenihan
- Daniel Lighezan
- Daniel Pauly
- Daniel Savard
- Daniel Vogel
- Daniela Garcia Brasca
- Daniela Pini
- Daniela Vinanska
- Dariusz Korczyk
- David Chang
- David F Kong
- David Henderson
- David Lanfear
- David Murray
- David Rawitscher
- David Schultz
- David Stepek
- David Whellan
- Debashis Roy
- Deddo Moertl
- Denis-Carl Phaneuf
- Dennis Rupka
- Deovrat Singh
- Devesh Patel
- Diana Bonderman
- Diaz R.
- Diego Alejandro Besada
- Diego Felipe Martinez
- Dimitrios Tziakas
- Dinesh Gupta
- Dipti Itchhaporia
- Dirk Boswijk
- Dirk Lok
- Dirk Schellings
- Dmitriy Belenkiy
- Dmitry Dronov
- Dmytro Reshotko
- Domenico Bonaduce
- Domingo Andres Pascual Figal
- Dongye Li
- Donna Mancini
- Dora Ines Molina de Salazar
- Douglas Brinkley
- Douglas Martel
- Douglas Sawyer
- Dragos Vinereanu
- Driek Beelen
- Dulce Brito
- Dumitru Zdrenghea
- Echeverria L. E.
- Edmundo Alfredo Bayram Llamas
- Edo Kaluski
- Eduardo Perna
- Eduardo Salcido Vazquez
- Edward Geltman
- Edward Portnay
- Egon Lenner
- Eileen O'Meara
- Einas Elmahi
- Eiran Gorodeski
- Elena Cowan
- Elena Kosmacheva
- Elena Kulibaba
- Elena Shutemova
- Ellis Lader
- Elvin Kedhi
- Erberto Carluccio
- Eric Decoulx
- Eric Klug
- Erik Hajko
- Ersel Onrat
- Ertugrul Okuyan
- Erwan Donal
- Eugene Chung
- Eugene Joseph Bauerlein
- Euler Roberto Fernandes Manenti
- Eva Goncalvesova
- Eva Peterfai
- Ewa Kalecinska-Krystkiewicz
- Ewa Straburzynska-Migaj
- Fabiana Rollini
- Fabio Silveira
- Fady I Malik
- Faiez Zannad
- Faisal Wahid
- Fang J. C.
- Farid Jadbabaie
- Felice Achilli
- Felix Ramires
- Feng Liu
- Ferenc Lakatos
- Fernando Bacal
- Fernando Boccalandro
- Fernando Colombo Berra
- Fernando Manzur Jattin
- Fernando Soto Loureiro
- Fernando Tomas Lanas Zanetti
- Filipa Almeida
- Filippatos G.
- Flavio Brito
- Flavio Eduardo Giorgeto
- Florence Rothenberg
- Florin Mitu
- Fonseca C.
- Fragkiskos Parthenakis
- Francesco Franchi
- Francisco Gonzalez Vilchez
- Francois Roubille
- Frank McGrew
- Frank Smart
- Frank Willems
- Franklin Handel
- François Picard
- Freny Mody
- Friedrich Fruhwald
- Fumi Yamamoto
- G Michael Felker
- Gabriel Arturo Ramos Lopez
- Gabriela Stanciulescu
- Gabriele Jakl-Kotauschek
- Gaetano Maria De Ferrari
- Garth Vaz
- Gary Yeoman
- Gaurav Aggarwala
- Georg Noll
- George Gabriel
- George Kochiadakis
- George Marzouka
- George Sokos
- Georgi Todorov
- Georgiy Dzyak
- Georgy Arbolishvili
- Gerardo Zapata
- Gerardus Linssen
- Gerasimos Filippatos
- Gerhard Poelzl
- Geza Lupkovics
- Giancarlo Piovaccari
- Gianfranco Sinagra
- Gianpiero Perna
- Gilmar Reis
- Gintare Sakalyte
- Giovanni Geronilla
- Giovanni Quinto Villani
- Giuseppe Ambrosio
- Giuseppe Musumeci
- Glenn Hamroff
- Goncalvesova E.
- Gordon Moe
- Gordon Reeves
- Goudev A. R.
- Gregorio Sanchez Vallejo
- Gregory Sampognaro
- Gregory Szto
- Gregory Thomas
- Grigorios Giamouzis
- Grzegorz Kania
- Grzegorz Skonieczny
- Guillaume De Geeter
- Guillaume Jondeau
- Guillermo Antonio Llamas Esperon
- Guoqin Chen
- Gurinder Grewal
- Gurusher Panjrath
- Gustavo Francisco Mendez Machado
- Guy Proulx
- Gyula Szasz
- Hakima Bourhaial
- Hal Skopicki
- Hamish Hart
- Hanbin Cui
- Hans Vandekerckhove
- Hans-Dirk Duengen
- Haralambos Karvounis
- Harinder Gogia
- Harukazu Iseki
- Hassan Ibrahim
- He Huang
- Heinz Drexel
- Hendrik Zimmet
- Henning Ebelt
- Henricus Van Kesteren
- Henrik Wiggers
- Henry Dargie
- Henry Ooi
- Hernan Emilio Francisco Polo Friz
- Hideki Ueno
- Hideo Izawa
- Hideo Kawakami
- Hideyuki Tsuboi
- Hiroaki Kitaoka
- Hiroaki Kiyokawa
- Hiroki Uehara
- Hiroshi Asano
- Hiroshi Domae
- Hiroshi Ito
- Hiroshi Meno
- Hiroshi Sugino
- Hiroshi Takaishi
- Hiroyuki Kawata
- Hisao Hara
- Hisashi Kai
- Holger Killat
- Honarpour N.
- Horacio Alberto Avaca
- Howlett J. G.
- Hugo Luquez
- Huifang Tang
- Ian Buysschaert
- Ibrahim Haldun Muderrisoglu
- Ichiro Michishita
- Ignacio Mackinnon
- Igor Kraiz
- Igor Motylev
- Igor Vakaliuk
- Iman Chouchane
- Imre Szakal
- Inder Anand
- Inder Singh
- Ioannis Barbetseas
- Ioannis Mantas
- Ioannis Styliadis
- Ira Dauber
- Irina Osipova
- Irina Semenova
- Iurii Rudyk
- Ivan Goncharov
- Ivan Majercak
- Ivana Kellnerova
- Ivaylo Vasilev
- Ivo Petrov
- Ivo Podpera
- J Dedrick Jordan
- J Russell Strader
- Jacob Eifer Moller
- Jacob Van Eck
- Jadwiga Nessler
- Jagadeesh Ganji
- James Elliott
- James Fang
- James L Januzzi
- James Rider
- James Watts
- Jan Belohlavek
- Jan Stevlik
- Jana Lukacova
- Janka Skrobakova
- Janos Tomcsanyi
- Janusz Spyra
- Jaroslaw Drozdz
- Jaroslaw Trebacz
- Jason C Legg
- Jason Glover
- Jasper Trevelyan
- Javed Butler
- Javier Segovia Cubero
- Javier Vasallo
- Jean Etienne Ricci
- Jean-Louis Georges
- Jean-Marie Lefebvre
- Jean-Michel Tartiere
- Jean-Noel Trochu
- Jean-Pierre Gueffet
- Jeffrey Martindale
- Jelena Celutkiene
- Jenica N Upshaw
- Jennifer Cook
- Jens Taggeselle
- Jeremy Cox
- Jeroen Schaap
- Jerzy Kopaczewski
- Jianjun Li
- Jindrich Spinar
- Jing Li
- Jing Yan
- Jinguo Zhang
- Jiri Krupicka
- Jiyan Chen
- Joao Carlos Braga
- Joaquin Martinez-Arraras
- Johanna Contreras
- Johannes Remmen
- John Amerena
- John Andrew Morrow
- John Atherton
- John Beltrame
- John Boehmer
- John Cleland
- John Collins
- John Corbelli
- John French
- John Groarke
- John Harris
- John Heitner
- John J V McMurray
- John Kao
- John Mignone
- John Murray
- John Parissis
- John van Hal
- Jolita Badariene
- Jonathan Howlett
- Jooyoung Shin
- Jorge Cheirif
- Jorge Leonardo Cobos Segarra
- Jorge Roberto Aiub
- Jorgen Jeppesen
- Jose Alfredo Pagola Carrasco
- Jose Augusto Ribas Fortes
- Jose Cardona
- Jose Francisco Saraiva
- Jose Luis Accini Mendoza
- Jose Luis Arenas Leon
- Jose Luis Lambert Rodriguez
- Jose Maria Arizon Del Prado
- Jose Ramon Gonzalez Juanatey
- Joseph Massaro
- Joseph Radojevic
- Joseph Rahman
- Joshua Asubiaro
- Jozef Gonsorcik
- Juan Francisco Delgado Jimenez
- Juan Jose Gomez Doblas
- Juan Londono
- Juan Luis Bonilla Palomas
- Julian Alonso Coronel Arroyo
- Julian Javier
- Juliano Cardoso
- Julio Eduardo Nuñez Villota
- Julio Ibañez
- Julio Tallet
- Jun Tanabe
- Junji Kanda
- Justin Ezekowitz
- Justin Taylor
- Kabir Yousuf
- Kahraman Cosansu
- Kalman Toth
- Kamil Zeman
- Kaoru Okishige
- Karel Peterka
- Karel Sochor
- Karen P Alexander
- Karen Sliwa
- Karl Dujardin
- Karl Heilman
- Katalin Bezzegh
- Katerina Naka
- Katsunori Kawamitsu
- Kazuhisa Mitsuo
- Keiji Ujino
- Keijiro Saku
- Keisuke Kida
- Keith Aaronson
- Keith Friedman
- Kenji Ando
- Kenji Onoue
- Kenneth Wong
- Kenshi Fujii
- Kentaro Nakamura
- Keyur Shah
- Kimberly Cruz
- Kimiaki Nagase
- Kirkwood Adams
- Klemens Ablasser
- Kodangudi Ramanathan
- Koichi Node
- Koichiro Sugimura
- Konstantin Zrazhevskiy
- Konstantinos Tsioufis
- Kotaro Numaguchi
- Kouji Kajinami
- Krzysztof Cymerman
- Kumiko Nakayama
- Kunihiko Makino
- Kurt Boman
- Kurt Huber
- Kurtz C. E. GALACTIC-HF Investigators: John R Teerlink
- Ladislav Busak
- Lana Tsao
- Lanfear D. E.
- Larry Allen
- Lars Videbaek
- Larysa Mishchenko
- Larysa Vasilyeva
- Laszlo Mark
- Laszlo Nagy
- Laura Jordan Martinez
- Laurie Letarte
- Lawrence Galitz
- Lawrence J Lesko
- Legg J. C.
- Leighton Kearney
- Lenka Spinarova
- Leonard Pianko
- Leonardo Macias
- Leonardo Novaretto
- Leonid Pimenov
- Leonid Rudenko
- Leonid Voronkov
- Leopoldo Soares Piegas
- Lesley Burgess
- Lesya Rasputina
- Li J.
- Libor Nechvatal
- Lidia Ana Zytynski Moura
- Lidia Pawlowicz
- Lilia Luz Lobo Marquez
- Lilia Nigro Maia
- Lilia Schiavi
- Liliana Nicolosi
- Lily Zhang
- Lisa Mielniczuk
- Liudmyla Alieksieieva
- Lixin Jiang
- Llyod Stahl
- Lokesh Chandra
- Louis Van Zyl
- Luanda Grazette
- Lubomir Antalik
- Luc Pierard
- Lucie Sharpsten
- Lucyna Lenartowska
- Luis Almenar Bonet
- Luis Beck da Silva Neto
- Luis de la Fuente Galan
- Luis Eduardo Echeverria
- Luis Eduardo Echeverria
- Luis Horacio Atehortua Lopez
- Luis Martinez
- Luis Oliveira
- Luis Santos
- Lund M.
- Lutfu Bekar
- Lutz Frankenstein
- Macdonald P.
- Maciej Zabowka
- Madhusudhan Pamganamamula
- Magnus Peterson
- Mahazarin Ginwalla
- Makoto Nakahama
- Makoto Usui
- Malgorzata Konieczynska
- Malgorzata Lelonek
- Malik F. I.
- Mamoru Manita
- Manoel Canesin
- Manohara Senaratne
- Manuel Bouza
- Manuel Eduardo Rodriguez Venegas
- Manuel Martinez-Selles D Oliveira Soares
- Manuel Odin De Los Rios Ibarra
- Marat Ezhov
- Marc Simon
- Marcelo Alejandro Garrido
- Marcin Szczasny
- Marco Metra
- Marcos Amuchastegui
- Marcos Raul Litvak Bruno
- Marcus Mittag
- Marcus Sandri
- Marcus Stoddard
- Marcus Vinicius Simoes
- Mareev V.
- Marek Houra
- Marek Piatek
- Margarita Gertrudis Vejar Jalaf
- Maria Alexandra Arias Mendoza
- Maria Cristina Schnettler Cid
- Maria Dorobantu
- Maria Frigerio
- Maria Generosa Crespo Leiro
- Maria Helena Vidotti
- Maria Leonor Parody
- Maria Sanali Paiva
- Maria Sitnikova
- Maria Teresa Blasco Peiro
- Maria Tzekova
- Mariel Rivero
- Mariela Rasmussen
- Marilena Renata Spiridon
- Mario Vega
- Mario Villoch
- Mario Yanez Hidalgo
- Marisa Crespo Leiro
- Marisa Orgera
- Mariusz Kafara
- Mark Abelson
- Mark Ramos
- Mark Smith
- Mark Zucker
- Martin Berk
- Martin Huelsmann
- Martin LeWinter
- Marvin A Konstam
- Mary Lynch
- Masahiro Ishikawa
- Masahiro Suzuki
- Masaki Yoshikawa
- Masanori Asakura
- Masaru Yuge
- Masayoshi Ajioka
- Masayuki Doi
- Masuki Mori
- Mateusz Sidor
- Mathue Baker
- Matt Wilkett
- Matteo Di Biase
- Matthew Janik
- Matthew Wheeler
- Matthias Dupont
- Maurizio Volterrani
- Mayanna Lund
- McMurray J. J. V.
- Mehmet Birhan Yilmaz
- Mehmet Birhan Yilmaz
- Mehmet Duzenli
- Mehrdad Ariani
- Melchor Alpizar Salazar
- Melvin Martinez-Castrillon
- Mesut Demir
- Metra M.
- Michael Boehm
- Michael Böhm
- Michael Felker G.
- Michael Hartleib
- Michael Koren
- Michael Kwan
- Michael Magro
- Michael Miyamoto
- Michael Pham
- Michael Radin
- Michal Cepelak
- Michel Galinier
- Michel Ovize
- Michele Hamilton
- Michele Senni
- Miguel Alfredo Moncada Corredor
- Miguel Angel Hominal
- Miguel Urina Triana
- Mikhail Kotelnikov
- Mikhail Voevoda
- Milan Gupta
- Mio Ebato
- Mircea Ioachim Popescu
- Mirta Diez
- Mitsuhiro Shimomura
- Mitsuru Tsujimoto
- Mitsutaka Yamamoto
- Mohammad Abuannadi
- Mohan Babapulle
- Momomura S.
- Monica Lopez Pareja
- Mori Krantz
- Mukesh Sharma
- Munir Janmohamed
- Muriel Salvat
- Mustafa Tuncer
- Mustafa Vural
- Mykola Rishko
- Mykola Stanislavchuk
- Nabil Dib
- Nadia Giannetti
- Naeem Tahirkheli
- Nampalli Vijay
- Nancy Sweitzer
- Nandini Nair
- Nandkishore Ranadive
- Naoki Sato
- Naoki Watanabe
- Narimon Honarpour
- Naseem Jaffrani
- Nasir Sulemanjee
- Natale Daniele Brunetti
- Nataliya Shilkina
- Nathan Mewton
- Natsuki Takahashi
- Navid Kazemi
- Navin Rajagopalan
- Neil Farris
- Neil Lewis
- Nicholas Kondo
- Nicole Lohr
- Niels Gadsboll
- Niels Menck
- Nikolay Tarasov
- Nishant Shah
- Nobuhide Miyamoto
- Nobuyuki Komiyama
- Noemi Nyolczas
- Nolan Mayer
- Norberto Duda
- Noriaki Takama
- Noriaki Utsu
- Norman Lepor
- Nqoba Tsabedze
- Nyda Fourie
- O'Meara E.
- Okan Onur Turgut
- Ole Nyvad
- Oleg Solovev
- Oleksandr Karpenko
- Oleksandr Parkhomenko
- Oleksandr Prokhorov
- Oleksii Korzh
- Oleksii Kulynych
- Olga Barbarash
- Olga Bolshakova
- Olga-Cristina Voicu
- Omar Almousalli
- Ondrej Jerabek
- Oscar Alberto Gomez Vilamajo
- Oscar Alejandro Salomone
- Oscar Romano Montana
- Oswaldo Greco
- Oswaldo Sandoval
- Otavio Coelho Filho
- Ozer Badak
- Paramdeep Baweja
- Parkhomenko A.
- Pascal De Groote
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- Valerio Zaca
- Valery Popov
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- Vasilios Papademetriou
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- Vilma Machova
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- Viorel Florea
- Vira Tseluyko
- Vittorio Giudici
- Viviane Nguyen
- Vladimir Cech
- Vladimir Cotarlan
- Vladimir Nosov
- Vladimir Rafalskiy
- Vladimir Salukhov
- Vladislav Mitrokhin
- Voors A. A.
- Vyacheslav Mareev
- Vyacheslav Ryabov
- W Schuyler Jones
- Wael AboAuda
- Wakaya Fujiwara
- Walter Abhayaratna
- Walter Droogne
- Walter Hermans
- Wataru Shimizu
- Wayne Gray
- Weiheng Wu
- Weimar Kunz Barroso de Souza
- Weimin Li
- Wentang Niu
- Wilder Castaño Osorio
- William Anderson
- William Herzog
- William Nelson
- William Randall
- Wissam Khalife
- Xin Fu
- Xuelian Zhang
- Xuming Yang
- Yafei Mi
- Yajun Han
- Yang Zheng
- Yanling Qu
- Yann Rosamel
- Yasuchika Takeishi
- Yasuhiro Maejima
- Yasuki Kihara
- Yasunori Ueda
- Yasuo Okumura
- Yasushi Sakata
- Yevgeniya Svishchenko
- Yi Wang
- Yilmaz M. B.
- Yinjun Li
- Yorihiko Higashino
- Yoshihiko Saito
- Yoshiki Hata
- Yoshinori Yasaka
- Yoshitoshi Urabe
- Yu Wei
- Yuemin Sun
- Yugang Dong
- Yuhui Zhang
- Yuji Nakazato
- Yukihiko Momiyama
- Yukihito Sato
- Yukiko Morita
- Yuksel Cavusoglu
- Yuqing Zhang
- Yurii Lymar
- Yuriy Mostovoy
- Yury Lukyanov
- Yury Shvarts
- Yutaka Akatsuka
- Yves Pesant
- Zannad F.
- Zbigniew Bednarkiewicz
- Zbigniew Chmielak
- Zbigniew Gola
- Zbigniew Kalarus
- Zbigniew Pijanowski
- Zbynek Pozdisek
- Zdenek Coufal
- Zdenek Klimsa
- Zdenek Monhart
- Zehra Lale Koldas
- Zerrin Yigit
- Zhanna Kobalava
- Zhanquan Li
- Zhaoping Li
- Zhe Zheng
- Zhenyu Yang
- Zhifang Wang
- Zoltan Laszlo
- Zsolt Zilahi
- Zuyi Yuan
- Zuzana Motovska
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve cardiac function in patients with heart failure with a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown. METHODS We randomly assigned 8256 patients (inpatients and outpatients) with symptomatic chronic heart failure and an ejection fraction of 35% or less to receive omecamtiv mecarbil (using pharmacokinetic-guided doses of 25 mg, 37.5 mg, or 50 mg twice daily) or placebo, in addition to standard heart-failure therapy. The primary outcome was a composite of a first heart-failure event (hospitalization or urgent visit for heart failure) or death from cardiovascular causes. RESULTS During a median of 21.8 months, a primary-outcome event occurred in 1523 of 4120 patients (37.0%) in the omecamtiv mecarbil group and in 1607 of 4112 patients (39.1%) in the placebo group (hazard ratio, 0.92; 95% confidence interval [CI], 0.86 to 0.99; P = 0.03). A total of 808 patients (19.6%) and 798 patients (19.4%), respectively, died from cardiovascular causes (hazard ratio, 1.01; 95% CI, 0.92 to 1.11). There was no significant difference between groups in the change from baseline on the Kansas City Cardiomyopathy Questionnaire total symptom score. At week 24, the change from baseline for the median N-terminal pro-B-type natriuretic peptide level was 10% lower in the omecamtiv mecarbil group than in the placebo group; the median cardiac troponin I level was 4 ng per liter higher. The frequency of cardiac ischemic and ventricular arrhythmia events was similar in the two groups. CONCLUSIONS Among patients with heart failure and a reduced ejection, those who received omecamtiv mecarbil had a lower incidence of a composite of a heart-failure event or death from cardiovascular causes than those who received placebo. (Funded by Amgen and others; GALACTIC-HF ClinicalTrials.gov number, NCT02929329; EudraCT number, 2016 -002299-28.)
Contributory presentations/posters
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- A. A. Tikhomirov
- A. Amadei
- A. Bhattacharya
- A. Bogdanov
- A. C. Campos de Carvalho
- A. C. Mauricio
- A. C. Mauricio
- A. Cole
- A. D. Beniaminov
- A. D. Kaulen
- A. Di Nola
- A. Di Nola
- A. Emanuele
- A. Faraone
- A. G. Degermendzhy
- A. G. Sizykh
- A. G. Tonevitsky
- A. German
- A. Gries
- A. H. Parola
- A. Holzenburg
- A. I. El-Awadi
- A. I. Kuzmenko
- A. Ishino
- A. J. W. G. Visser
- A. J. Wein
- A. Jellali
- A. Johnson
- A. K. Bandyopadhyay
- A. K. Basak
- A. K. Basak
- A. K. Bera
- A. K. Bera
- A. K. Mishra
- A. K. Mishra
- A. K. Pal
- A. K. Pal
- A. K. Sharma
- A. K. Singh
- A. K. Tonkikh
- A. Khachatryan
- A. Kumar
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- V. Manko
- V. Martorana
- V. Martorana
- V. Mkheyan
- V. Mohan Kumar
- V. N. Shikhov
- V. N. Shilov
- V. Nastasa
- V. Natarajan
- V. P. Bubnov
- V. P. Skulachev
- V. R. Srinivas
- V. Rani Parvathy
- V. S. Chauhan
- V. S. Chubanov
- V. S. Shelkovsky
- V. V. Adamovich
- V. V. Rosin
- V. Villari
- Vasantha Pattabhi
- Vera Pingoud
- Vettai S. Ananthanaravanan
- Vettai S. Ananthanarayanan
- Victor Muñoz
- Vidva Raghunathan
- Vikas Chandra
- Vinod Bhakuni
- Vinod Bhakuni
- Vitaly K. Koltover
- Vito Stare
- Vivian Stojanoff
- Vlnod Bhakuni
- W. A. Varanda
- W. Bild
- W. H. Sawyer
- W. J. Chien
- W. Müller
- W. Schmahl
- W. Seidenbusch
- Wang Bao Han
- Wang Jushuo
- Wang Zhi Xin
- Wei-ying Cheng
- Wen-rui Chang
- Werner Kühlbrandt
- William A. Eaton
- Wolfgang Höhne
- Wolfgang Jahnke
- Wolfgang Wende
- Xiao-jian Hu
- Xun Shen
- Y-M. Zheng
- Y. -H. Sanejouand
- Y. Blouquit
- Y. Husimi
- Y. Kirino
- Y. Kishimoto
- Y. Kyogoku
- Y. Lin
- Y. M. Allakhverdieva
- Y. Nakato
- Y. Pesotskaya
- Y. Rubin
- Y. Shibata
- Y. Suezaki
- Y. U. Sasidhar
- Ya. I. Estrin
- Yasuhiro Kumaki
- Yasunori Yokoyama
- Yogesh Kumar
- Yoichi Hayakawa
- Yoichiro Ito
- Yoshihiro Kobashigawa
- Yoshitoshi
- Yoshiyuki Amemiya
- Yosiyuki Sowa
- Yu. Babayan
- Yu. P. Blagoy
- Yu. P. Chukova
- Yu. S. Babayan
- Yuan Zheng
- Yuji Kimura
- Yuki Fukuoka
- Yuki Nakagawa
- Yuling Yan
- Yuri Mukai
- Yuri Mukai
- Yuri N. Antonenko
- Yuriko Yamagata
- Yuriko Yamagata
- Yusuke Iguchi
- Yuzuru Husimi
- Yves Blouquit
- Z. B. Li
- Z. Combos
- Z. Cseh
- Z. Földes-Papp
- Z. Gombos
- Z. Guttenberg
- Z. Lobo
- Z. S. Várkonyi
- Z. Stolič
- Z. Tronteli
- Zeno Földes-Papp
- Zhao Nanming
- Zhi-hong Zhang
- Zs. Várkonyi
- Zvi Priel
- Á. Bódi
- Éric Quinjou
- Ü. Mets
- Č. N. Radenović
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study