Parenting Styles, Bullying Behavior and Mental Health of Prisoners

The current study examined the association between parenting styles, bullying behavior, and the mental health of prisoners. We hypothesize that there was likely to be a positive relationship between parenting styles and bullying behavior, respectively, and there was likely to be a positive relationship between parenting styles and the mental health of prisoners in jail. It was also hypothesized that there is expected to be a negative relationship between bullying behavior and mental health, and bullying behavior was likely to mediate between parenting styles and the mental health of prisoners. The study uses a cross-sectional research design and purposive sampling strategy to recruit 134 participants (Men=, 104, Women=30). The sample was within the age range of 18-55 years (M=35.13& SD=9.65). Demographic sheet, Parental Authority Questionnaire-short version, Direct and Indirect Prisoners Behavior Checklist-R, and Mental Health Inventory were administrated. Correlational analysis revealed a strong correlation among parenting styles, bullying behavior, and mental health. Hierarchal multiple regression analysis revealed that bullying behavior also strongly predicts mental health. The predictor, parenting styles, partially predicts mental health, as one parenting style out of three showed a significant variance in the outcome

Parenting Styles, Bullying Behavior and Mental Health of Prisoners

The current study examined the association between parenting styles, bullying behavior, and the mental health of prisoners. We hypothesize that there was likely to be a positive relationship between parenting styles and bullying behavior, respectively, and there was likely to be a positive relationship between parenting styles and the mental health of prisoners in jail. It was also hypothesized that there is expected to be a negative relationship between bullying behavior and mental health, and bullying behavior was likely to mediate between parenting styles and the mental health of prisoners. The study uses a cross-sectional research design and purposive sampling strategy to recruit 134 participants (Men=, 104, Women=30). The sample was within the age range of 18-55 years (M=35.13& SD=9.65). Demographic sheet, Parental Authority Questionnaire-short version, Direct and Indirect Prisoners Behavior Checklist-R, and Mental Health Inventory were administrated. Correlational analysis revealed a strong correlation among parenting styles, bullying behavior, and mental health. Hierarchal multiple regression analysis revealed that bullying behavior also strongly predicts mental health. The predictor, parenting styles, partially predicts mental health, as one parenting style out of three showed a significant variance in the outcome

A comprehensive review on the diverse pharmacological perspectives of Terminalia chebula Retz

Terminalia chebula Retz, commonly known as ‘Haritaki/Myrobalan,’ has been utilised as a traditional medicine for a long time. It has been extensively exercised in various indigenous medicine practices like Unani, Tibb, Ayurveda, and Siddha to remedy human ailments such as bleeding, carminative, dysentery, liver tonic, digestive, antidiarrheal, analgesic, anthelmintic, antibacterial and helpful in skin disorders. Studies on the pharmacological effects of T. chebula and its phytoconstituents documented between January, 1996 and December, 2021 were explored using various electronic databases. During the time mentioned above, several laboratory approaches revealed the biological properties of T. chebula, including antioxidative, antiproliferative, anti-microbial, proapoptotic, anti-diabetic, anti-ageing, hepatoprotective, anti-inflammatory, and antiepileptic. It is also beneficial in glucose and lipid metabolism and prevents atherogenesis and endothelial dysfunction. Different parts of T. chebula such as fruits, seeds, galls, barks extracted with various solvent systems (aqueous, ethanol, methanol, chloroform, ethyl-acetate) revealed major bioactive compounds like chebulic acid, chebulinic acid, and chebulaginic acid, which in turn proved to have valuable pharmacological properties through broad scientific investigations. There is a common link between chebulagic acid and chebulanin with its antioxidant property, antiaging activity, antiinflammatory, antidiabetic activity, and cardioprotective activity. The actions may be through neutralizing the free radicals responsible for producing tissue damage alongside interconnecting many other diseases. The current review summarises the scientifically documented literature on pharmacological potentials and chemical compositions of T. chebula, which is expected to investigate further studies on this subject

Guideline-directed medical therapy use and decision making in chronic and acute, pre-existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction – the ESC EORP Heart Failure III Registry

Funding Information: This work was supported by the following companies since the start of EORP and for the period of the ESC Heart Failure III study: Abbott Vascular Int. (2018\u20132021), Amgen Cardiovascular (2016\u20132018), AstraZeneca AB (2017\u20132020), Bayer AG (2016\u20132018), Boehringer Ingelheim (2016\u20132019), Bristol Myers Squibb (2017\u20132019), Daichii Sankyo Europe GmbH (2017\u20132020), Edwards Lifesciences (2016\u20132019), Novartis Pharma AG (2018\u20132020), Servier (2015\u20132021), and Vifor (2019\u20132021). Publisher Copyright: © 2024 European Society of Cardiology.Aims: We analysed baseline characteristics and guideline-directed medical therapy (GDMT) use and decisions in the European Society of Cardiology (ESC) Heart Failure (HF) III Registry. Methods and results: Between 1 November 2018 and 31 December 2020, 10 162 patients with acute HF (AHF, 39%, age 70 [62–79], 36% women) or outpatient visit for HF (61%, age 66 [58–75], 33% women), with HF with reduced (HFrEF, 57%), mildly reduced (HFmrEF, 17%) or preserved (HFpEF, 26%) ejection fraction were enrolled from 220 centres in 41 European or ESC-affiliated countries. With AHF, 97% were hospitalized, 2.2% received intravenous treatment in the emergency department, and 0.9% received intravenous treatment in an outpatient clinic. AHF was seen by most by a general cardiologist (51%) and outpatient HF most by a HF specialist (48%). A majority had been hospitalized for HF before, but 26% of AHF and 6.1% of outpatient HF had de novo HF. Baseline use, initiation and discontinuation of GDMT varied according to AHF versus outpatient HF, de novo versus pre-existing HF, and by ejection fraction. After the AHF event or outpatient HF visit, use of any renin–angiotensin system inhibitor, angiotensin receptor–neprilysin inhibitor, beta-blocker, mineralocorticoid receptor antagonist and loop diuretics was 89%, 29%, 92%, 78%, and 85% in HFrEF; 89%, 9.7%, 90%, 64%, and 81% in HFmrEF; and 77%, 3.1%, 80%, 48%, and 80% in HFpEF. Conclusion: Use and initiation of GDMT was high in cardiology centres in Europe, compared to previous reports from cohorts and registries including more primary care and general medicine and regions more local or outside of Europe and ESC-affiliated countries.publishersversionepub_ahead_of_prin

Retinal Surgery-Induced Trigeminal Neuralgia

Purpose: To report a case of trigeminal neuralgia after retinal surgery in a 72-year-old man. Methods: Case report. Results: A 72-year-old man developed severe postoperative pain after undergoing vitrectomy and endolaser therapy. The pain responded to neuroleptic medications once a diagnosis of trigeminal neuralgia was made. Conclusion: The authors report a case of trigeminal neuralgia developed after vitreoretinal surgery. Clinicians should consider trigeminal neuralgia in the differential diagnosis of atypical pain after retinal surgery. Copyright © Lippincott Williams & Wikins. Unauthorized reproduction of this article is prohibited

Caractérisation d'entités moléculaires de surface impliquées dans la relation de la bactérie probiotique Lactobacillus plantarum 299v avec l'hôte (approche in vitro)

Les microorganismes probiotiques mis en œuvre dans les aliments fonctionnalisés, sont capables de produire des effets bénéfiques sur la santé du consommateur. Ces effets dépendent entre autres de la capacité d adhésion des probiotiques aux constituants de l épithélium intestinal. L adhésion, est un phénomène complexe dépendant des propriétés physico-chimiques de la surface bactérienne ainsi que de la présence d entités protéiques et/ou non protéiques possédant une affinité pour les constituants de la muqueuse intestinale de l hôte. Au travers de l étude de l hydrophobie/hydrophilie et de la charge électrique de la surface de la souche probiotique Lactobacillus plantarum 299v ainsi que de celles d autres souches adhérentes de L. plantarum, une absence de corrélation entre de telles propriétés et la capacité d adhésion des souches sur les cibles mucine et cellules épithéliales intestinales Caco-2 a été établie. La caractérisation systématique des protéines associées à la paroi de L. plantarum 299v suivie de l estimation de leur affinité pour des cibles de la surface intestinale, ont conduit à l identification de la glyceraldéhyde-3-phosphate déshydrogénase (GAPDH) en tant qu adhésine potentielle. L analyse, par cytométrie en flux, des cellules de L. plantarum 299 v marquées par des anticorps anti-GAPDH et par l iodure de propidium a permis d établir un lien entre la perte d intégrité de la membrane plasmique et la présence de cette anchorless protein associée à la paroi bactérienne. Cette observation conduit à la proposition d un mécanisme original concernant l exportation de l enzyme cytoplasmique à la surface de la bactérie. D autres polymères non protéiques de type acides lipoteichoïques associés à la paroi, ont été caractérisés et leur implication dans l interaction de L. plantarum 299v avec la mucine et les cellules épithéliales intestinales Caco-2 a été démontrée.The probiotic microorganisms implemented in functionalized foods can produce beneficial effects on consumer health. These effects depend on the adhesion ability of probiotics to the constituents of the intestinal tract. The phenomenon of bacterial adhesion is a complex process which is mediated by the physico-chemical properties of the bacterial surface and by a set of proteinaceous and non-proteinaceous molecular entities with specific binding abilities to constituents of the host intestinal mucosa. Through the study of the hydrophobic/hydrophilic character and electric charge of the probiotic strain Lactobacillus plantarum 299v and those of other adherent strains of L. plantarum, no correlation between such properties and their adhesion ability to mucin and Caco-2 epithelial cells was established. The systematic characterization of the cell wall associated proteins of L. plantarum 299v followed by the estimation of their affinities for targets of the intestinal surface, led to the identification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a potential adhesin. Flow cytometry analysis of L. plantarum 299v cells labelled with anti-GAPDH and propidium iodide unambiguously confirmed a relationship between the loss of the plasma membrane integrity and location on cell wall of GAPDH and probably of other "anchorless protein". This observation led to us the proposal of an original mechanism on the export of this cytoplasmic enzyme to the bacterial cell wall surface. Other non-proteinaceous polymers like lipoteichoic acids have been characterized and their involvement in the interaction of L. plantarum 299v to mucin and Caco-2 monolayer cells was demonstrated.LIMOGES-BU Sciences (870852109) / SudocSudocFranceF

Etude descriptive et profil épidémiologique des affections bucco-dentaires observées au service de pathologie bucco-dentaire du CHU Tizi-Ouzou

Les pathologies de la sphère cervico-faciale regroupent des entités très variées dont on a divisé en 3 principaux groupes : les pathologies infectieuses, les pathologies traumatiques et les pathologies tumorales. Dans le but de déterminer les pathologies les plus fréquentes, une étude de type descriptive a été menée sur les différentes pathologies rencontrées au service de pathologie bucco-dentaire du CHU Nedir Mohamed de TiziOuzou du 15 Janvier 2020 jusqu'au 12 mars 2020, elle a été interrompue par la pandémie du covid 19. Elle a été portée sur un échantillon de 216 patients de different âges dont l'âge moyen était de 30ans, et les deux sexes dont le sexe féminin était le predominant avec un sexe ratio de 1,57 en faveur des femmes. On a reçu aussi des patients présentant des maladies générales associées. La plupart des pathologies surviendraient à un âge jeune, la classe d’âge de20 à 29 ans a été la plus déterminante. Au sein du service de pathologie et chirurgie buccales, les cellulites cervico-faciales représentent une pathologie assez fréquente et variée par leur formes cliniques, cette fréquence élevée est fonction de la fréquence des affections dentaires, en particulier des dents mortifiées, point de départ des complications locales, locorégionales et générales. La prise en charge médico-chirurgicale comprend essentiellement l’élimination du foyer infectieux dentaire. Si la preuve est donnée par différents auteurs qu’un traitement bien conduit et appliqué précocement est susceptible d’améliorer le pronostic, il n’en demeure pas moins que le meilleur traitement reste préventif. La prévention passe par tous les moyens de prévention de la carie et un examen odontologique régulier qui permet de diagnostiquer les lésions dentaires et de les traiter précocement afin d'éviter l'installation de complications

Subtractive Proteomics Supported with Rational Drug Design Approach Revealed ZINC23121280 as a Potent Lead Inhibitory Molecule for Multi-drug Resistant Francisella tularensis

Francisella tularensis is a Gram-negative bacterium and is the etiological agent of taluremia. The prolonged use of antibiotics is the reason for pathogen resistance to antibiotics such as beta-lactams and macrolides. This leads to the search to explore novel drug targets for F. tularensis to inhibit its growth. Subtractive proteomics revealed Glucose-1-phosphate thymidylyltransferase (G1PTT) as the most promising protein as a drug target. A pharmacophore model was generated for virtual screening of a druglike library comprised of 1,000,000 drug molecules. Based on a pharmacophore-based search, a set of 152 compounds was predicted as the most potent inhibitors against this enzyme. The screened hits were docked with the target enzyme; which unveiled ZINC23121280 as the best-docked inhibitor having Autdock Vina binding energy of -7.2 kcal/mol and the GOLD score of 64.06. Moreover, the timedependent dynamic behavior of the complex was analyzed using Molecular Dynamics (MD) simulation studies that revealed a stable system with a Root Mean Square Deviation (RMSD) average value of 2.25 Å and Root Mean SquareFluctuations (RMSF) of 1.16 Å. Radial Distribution Function (RDF) predicted strong hydrogen interactions between the ligand and Trp221 from the enzyme active pocket. The higher affinity of the antagonist for the enzyme was further supported by Molecular Mechanics Energies combined with the Poisson–Boltzmann and Surface Area (MMPBSA) and or Generalized Born and Surface Area (MMGBSA) with the estimated binding free energy of −1.07 kcal/mol and −29.59 kcal/mol, respectively. Findings from this present computational framework may provide the foundation for future drug discovery against F. tularensis.</jats:p