Blood Pressure and Age Are the Main Determinants of Aortic Stiffness

WOS: 000418303200017PubMed ID: 28982100

The Relationship of Red-Cell Distribution Width and Carotid Intima Media in Chronic Kidney Disease

AMAÇ: Eritrosit dağılım genişliği (RDW) rutin olarak tam kan sayımından elde edilen bir parametredir. Son yıllarda yapılan çalışmalarda kardiyovasküler hastalığı olanlarda ve sağlıklı gönüllülerde RDW'nin kardiyovasküler hastalıklarla ilişkili olduğu gösterilmiştir. Böbrek yetmezliği hastalarında RDW ile ilgili yeterli çalışma yoktur. Biz kronik böbrek yetmezliği hastalarında RDW'nin aterosklerozun bir ön göstergesi olan karotis intima media kalınlığı (IMK) ile ilişkisini araştırdık.GEREÇ ve yÖNTEMLER: 30 sağlıklı kontrol, 30 kronik böbrek yetmezliği hastası, 37 hemodiyaliz hastası çalışmaya alındı. Hastaların ultrasonografik yöntem ile IMK değerleri ölçüldü. BULGULAR: CRP (p=0,039), hemoglobin (p<0,001), IMK (p<0,001), RDW(p<0,001), üre (p<0,001), kreatinin (p<0,001), albumin (p<0,001), ürik asit (p<0,001) ve ferritin (p<0,001) değerlerinde her üç grup arasında istatistiksel olarak anlamlı farklılık tespit edildi. Posthok analizde IMK değeri prediyaliz grubunda (p<0,001) ve hemodiyaliz grubunda (p<0,001) sağlıklı kontrollere göre istatistiksel olarak anlamlı yüksek tespit edildi. Hemodiyaliz ve prediyaliz gruplarının ortalama IMK değerleri arasında istatistiksel farklılık tespit edilmedi (p:0,988). RDW değeri hemodiyaliz grubunda control grubuna (p:0,046) ve prediyaliz grubuna (p:0,03) göre yüksek saptandı. RDW değeri prediyaliz grubunda control grubuna göre istatistiksel anlalmlılık sınırına yakın yüksek tespit edildi (p: 0,067). RDW değeri IMK (r: 0,356 P: 0,012 ) ve CRP (r: 0,361 P: 0,004 ) ile pozitif korelasyon, gösterdi.SONUÇ: Kronik böbrek yetmezliği hastalarında RDW inflamasyon ve intima media kalınlığı ile ilişkilidir.OBJECTIVE: Red-cell distribution width (RDW) is a parameter routinely used for diagnosis of different anemia types. Recent studies have shown the RDW relationship with mortality in general population and patients with cardiovascular disease. However, the number of studies on RDW in chronic kidney disease (CKD) is insufficient. We evaluated the relationship between RDW and carotid intima media thickness (IMT), which is a predictor of atherosclerosis, in patients with CKD.MATERIAL and METHODS: 30 healthy controls, 30 patients with CKD, 37 hemodialysis patients were included. IMT was measured with ultrasonography. RESULTS: We identified statistically significant differences in CRP (p: 0.039), hemoglobin (p<0.001), IMK (p<0.001), RDW (p<0.001), urea (p<0.001), creatinine (p<0.001), albumin (p<0.001), uric acid (p<0.001) and ferritin (p<0.001) levels among three groups. In post hoc analysis, the IMK value was statistically significantly higher in the predialysis (p<0.001) and hemodialysis group than healthy controls. IMK value was not statistically different in the hemodialysis group than the predialysis group (p: 0.988). The RDW value was higher in the predialysis group than controls with a trend to statistical significance (p: 0.067). RDW value showed positive correlation with IMK (r: 0.356 P: 0.012) and CRP (r: 0.361 P: 0.004). CONCLUSION: RDW is associated with inflammation and intima media thickness in patients with CKD

The nailfold videocapillaroscopy findings of Behçet's syndrome

Background: Nailfold videocapillaroscopy (NVC) is a diagnostic method for evaluating the microvasculature. Behçet's disease (BD) can affect vessels of all types and sizes. Methods: We performed NVC in 82 randomly selected patients with BD. NVC was performed for eight fingers (excluding the thumbs) with a 200× magnification. Results: Of the 82 patients with BD, 75 had at least one capillaroscopic change, including tortuosity in 75 (91.5%), bizarre capillaries in eight (9.8%), microhemorrhages in four (4.9%) and mega capillary in two (2.4%). The mean number of capillaries/mm length of nailfold in the group with BD was 10.17 ± 1.23 and was 11.45 ± 0.99 in the healthy controls (p < 0.001). Conclusion: In this study, the BD group had significantly more capillaroscopic pathological findings than did the healthy control group. However, the detected capillaroscopic pathology rate in BD patients was significantly lower than that of three previously published studies. Further studies are needed to clarify the diagnostic and prognostic value of capillaroscopy in BD

Prognostic factors in patients with metastatic urothelial carcinoma who have been treated with atezolizumab

Background: In the current study, we evaluated pretreatment prognostic factors foroverall survival (OS) in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy in the Expanded-Access Program ofatezolizumab.Methods: In this study, we present the retrospective analysis of 113 patients withurothelial cancer treated with ATZ after progression on first-line chemotherapy.Eligible patients included metastatic urothelial carcinoma patients treated with at leastone course of ATZ. Univariate analysis was used to identify clinical and laboratoryfactors that significantly impact OS. Variables were retained for multivariate analysis ifthey had a statistical relationship with OS (P˂0.1) and were then included the finalmodel if P˂0.05.Results: In univariate analysis, primary tumour location in the upper tract, increasedabsolute neutrophil count (ANC), increased absolute lymphocyte count, neutrophil-tolymphocyte ratio (NLR)>3, liver metastases, baseline creatinine clearance (GFR) 3 (HR¼ 0.474; 95% CI 0.234-0.962; P ¼0.039) and GFR 3 andGFR <60 ml/min. Taken together, these factors can be used for prognostic parametersin clinical trials that use immunotherapy in patients with bladder cancer who haveprogressed after first-line chemotherapy.European Society for Medical Oncolog

Is there increased risk of childhood cancers after assisted reproductive techniques?

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Atezolizumab in patients with metastatic urothelial carcinoma who have progressed after first-line chemotherapy: Results of real-life experience

...American Society of Clinical Oncolog