HIV interactions with monocytes and dendritic cells: viral latency and reservoirs

HIV is a devastating human pathogen that causes serious immunological diseases in humans around the world. The virus is able to remain latent in an infected host for many years, allowing for the long-term survival of the virus and inevitably prolonging the infection process. The location and mechanisms of HIV latency are under investigation and remain important topics in the study of viral pathogenesis. Given that HIV is a blood-borne pathogen, a number of cell types have been proposed to be the sites of latency, including resting memory CD4+ T cells, peripheral blood monocytes, dendritic cells and macrophages in the lymph nodes, and haematopoietic stem cells in the bone marrow. This review updates the latest advances in the study of HIV interactions with monocytes and dendritic cells, and highlights the potential role of these cells as viral reservoirs and the effects of the HIV-host-cell interactions on viral pathogenesis

Paracoccidioidomicose: atualização epidemiológica, clínica e terapêutica Paracoccidioidomycosis: epidemiological, clinical and treatment up-date

São apresentados dados de atualização epidemiológica, clínica, diagnóstica e terapêutica relativos à paracoccidioidomicose. Discute-se a importância epidemiológica resultante do isolamento do Paracoccidioides brasiliensis a partir do tatu (Dasypus novemcinctus) em regiões do Brasil e Colômbia, assim como dos resultados de inquéritos soroepidemiológicos em cães e do surgimento do primeiro caso de paracoccidioidomicose doença em cão. As dificuldades de isolamento do fungo a partir do solo são correlacionadas com novos informes de investigação epidemiológica. São apresentados aspectos clínicos das manifestações da forma aguda da doença, assim como das manifestações da neuroparacoccidioidomicose e da enfermidade associada à infecção pelo HIV. Discute-se o papel da sorologia e da técnica da PCR no diagnóstico e dos possíveis avanços no tratamento da paracoccidioidomicose com os novos derivados triazólicos.<br>The present report provides new data related to the epidemiology, clinical aspects and treatment of paracoccidioidomycosis. The epidemiological impact of the isolation of Paracoccidioides brasiliensis from the armadillo (Dasypus novemcinctus) in areas of Brazil and Columbia, the results from seroepidemiologic study in dogs and the first case of paracoccidioidomycosis-disease on a dog are presented. New insights related to the classical difficulties of isolation of the fungus from soil are correlated with epidemiological data. Clinical manifestation of the acute form of the disease as well as aspects of the neuroparacoccidioidomycosis, and aspects of the association of the disease with the HIV infection are considered. The role of serology and PCR in the diagnosis, as well as the possible advances in the treatment of paracoccidioidomycosis with the new triazole derivatives are discussed

Structural control and system-level behavior of the seismic cycle at the Nankai Trough

The Nankai Trough in Southwest Japan exhibits a wide spectrum of fault slip, with long-term and short-term slow-slip events, slow and fast earthquakes, all associated with different segments down the plate interface. Frictional and viscous properties vary depending on rock type, temperature, and pressure. However, what controls the down-dip segmentation of the Nankai subduction zone megathrust and how the different domains of the subduction zone interact during the seismic cycle remains unclear. Here, we model a representative cross-section of the Nankai subduction zone offshore Shikoku Island where the frictional behavior is dictated by the structure and composition of the overriding plate. The intersections of the megathrust with the accretionary prism, arc crust, metamorphic belt, and upper mantle down to the asthenosphere constitute important domain boundaries that shape the characteristics of the seismic cycle. The mechanical interactions between neighboring fault segments and the impact from the long-term viscoelastic flow strongly modulate the recurrence pattern of earthquakes and slow-slip events. Afterslip penetrates down-dip and up-dip into slow-slip regions, leading to accelerated slow-slip cycles at depth and long-lasting creep waves in the accretionary prism. The trench-ward migrating locking boundary near the bottom of the seismogenic zone progressively increases the size of long-term slow-slip events during the interseismic period. Fault dynamics is complex and potentially tsunami-genic in the accretionary region due to low friction, off-fault deformation, and coupling with the seismogenic zone.Published versionThis study was funded by the National Science Foundation under grant no. EAR-1848192