34 research outputs found
Essential function for ErbB3 in breast cancer proliferation
The overexpression of the ErbB family of tyrosine kinase receptors is thought to be important in the development of many breast tumours. To date, most attention has focused on the ErbB2 receptor. Now, in a recent report, it has been shown that ErbB3 is a critical partner for the transforming activity of ErbB2 in breast cancer cells. Importantly, the proliferative signals from this transforming complex appear to act via the PI-3 kinase pathway
Federated Learning for Breast Density Classification: A Real-World Implementation
Building robust deep learning-based models requires large quantities of
diverse training data. In this study, we investigate the use of federated
learning (FL) to build medical imaging classification models in a real-world
collaborative setting. Seven clinical institutions from across the world joined
this FL effort to train a model for breast density classification based on
Breast Imaging, Reporting & Data System (BI-RADS). We show that despite
substantial differences among the datasets from all sites (mammography system,
class distribution, and data set size) and without centralizing data, we can
successfully train AI models in federation. The results show that models
trained using FL perform 6.3% on average better than their counterparts trained
on an institute's local data alone. Furthermore, we show a 45.8% relative
improvement in the models' generalizability when evaluated on the other
participating sites' testing data.Comment: Accepted at the 1st MICCAI Workshop on "Distributed And Collaborative
Learning"; add citation to Fig. 1 & 2 and update Fig.
Identification of a mitotic recombination hotspot on chromosome III of the asexual fungus Aspergillus niger and its possible correlation elevated basal transcription
Genetic recombination is an important tool in strain breeding in many organisms. We studied the possibilities of mitotic recombination in strain breeding of the asexual fungus Aspergillus niger. By identifying genes that complemented mapped auxotrophic mutations, the physical map was compared to the genetic map of chromosome III using the genome sequence. In a program to construct a chromosome III-specific marker strain by selecting mitotic crossing-over in diploids, a mitotic recombination hotspot was identified. Analysis of the mitotic recombination hotspot revealed some physical features, elevated basal transcription and a possible correlation with purine stretches