1 research outputs found
Gd-Dots with Strong Ligand–Water Interaction for Ultrasensitive Magnetic Resonance Renography
Magnetic
resonance imaging contrast agents with both significantly
enhanced relaxivity and minimal safety risk are of great importance
for sensitive clinical diagnosis, but have rarely been reported. Herein,
we present a simple strategy to improve relaxivity by introducing
surface ligands with strong interaction to water molecules. As a proof
of concept, NaGdF<sub>4</sub> nanoparticles (NPs) capped by polyÂ(acrylic
acid) (PAA) show superior relaxivity to those capped by polyethylenimine
and polyethylene glycol, which is attributed to the strong hydrogen-bond
capacity of PAA to water molecules as revealed by theoretical calculation.
Furthermore, benefiting from PAA and ultrasmall particle size, Gd-dots,
namely PAA-capped GdOF NPs (2.1 ± 0.2 nm), are developed as a
high-performance contrast agent, with a remarkable ionic relaxivity
of ∼75 mM<sup>–1</sup> s<sup>–1</sup> in albumin
solution at 0.5 T. These Gd-dots also exhibit efficient renal clearance
with <3% of injected amount left 12 h post-injection. Ultrasensitive
MR renography achieved with Gd-dots strongly suggests their great
potential for practical applications