Von der weltkulturellen Bedeutung und Aufgabe des Judentums

Nahum Goldman

Die drei Forderungen des jüdischen Volkes

von Nachum Goldman

Erez-Israel : Reisebriefe

von Nachum GoldmannAus der Sammlung des Leo Baeck Institute, digitalisiert in Kooperation mit dem Center for Jewish History, N

[Handwritten letters from Nachum Goldmann to Blanca Löw-Weiner] circa 1922-1933

Personal letters and cards written by Goldmann to Blanca Löw-Weiner in Vienna. A large number of the letters are on Goldmann's stationery listing an address in Berlin-Charlottenburg, so it is likely the correspondence dates to the 1920s or very early 1930s when the Verlag Eschkol was active. There are also letters written on the stationery of various European and Palestinian hotels.Hagit Gor-Ziv (via Daniel Levy)Removed from # 194322Processed for digitizationSent for digitizationReturned from digitizationLinked to online manifestationdigitize

Erez-Israel : Reisebriefe /

Reisebriefe.--Die schulen Palästinas.CatalogingDigital imageDescription based on print version record

Letters to the Editor

None available

Fibroblast growth factors induce hepatic tumorigenesis post radiofrequency ablation

Abstract Image-guided radiofrequency ablation (RFA) is used to treat focal tumors in the liver and other organs. Despite potential advantages over surgery, hepatic RFA can promote local and distant tumor growth by activating pro-tumorigenic growth factor and cytokines. Thus, strategies to identify and suppress pro-oncogenic effects of RFA are urgently required to further improve the therapeutic effect. Here, the proliferative effect of plasma of Hepatocellular carcinoma or colorectal carcinoma patients 90 min post-RFA was tested on HCC cell lines, demonstrating significant cellular proliferation compared to baseline plasma. Multiplex ELISA screening demonstrated increased plasma pro-tumorigenic growth factors and cytokines including the FGF protein family which uniquely and selectively activated HepG2. Primary mouse and immortalized human hepatocytes were then subjected to moderate hyperthermia in-vitro, mimicking thermal stress induced during ablation in the peri-ablational normal tissue. Resultant culture medium induced proliferation of multiple cancer cell lines. Subsequent non-biased protein array revealed that these hepatocytes subjected to moderate hyperthermia also excrete a similar wide spectrum of growth factors. Recombinant FGF-2 activated multiple cell lines. FGFR inhibitor significantly reduced liver tumor load post-RFA in MDR2-KO inflammation-induced HCC mouse model. Thus, Liver RFA can induce tumorigenesis via the FGF signaling pathway, and its inhibition suppresses HCC development