Patient characteristics with and without DIC.

<p>Patient characteristics with and without DIC.</p

Patient demographics.

<p>Patient demographics.</p

Correlations between ROTEM and ICU-scores.

<p>Correlations (r_s) between ROTEM maximum clot firmness (MCF) for ExTEM and intensive care unit (ICU) scores. Sequential organ failure assessment (SOFA) score (A), disseminated intravascular coagulopathy (DIC) scores according to ISTH (B) and JAAM (C). ** = p <0.01.</p

Relationship between aPTT measured using various reagents, and the logarithm of thrombin generation.

<p>See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.t003" target="_blank">Table 3</a> for correlation factors and regression lines. There is a negative linear relationship between aPTT and log₁₀(ETP). Tinzaparin results in prolonged aPTT results compared to enoxaparin in the whole blood analyses (FOR and Hemochron Jr) at any given level of thrombin generation.</p

Correlations between routine laboratory assays and POC assays.

<p>Correlations (r_s) between platelet count and Multiplate area under the curve (AUC) for adenosine-5´-diphosphate (ADP) (A), collagen (B), thrombin receptor agonist peptide (TRAP) (C) and ROTEM maximum clot firmness (MCF) for ExTEM (D), maximum clot lysis (ML) for ExTEM (E) and MCF for FibTEM (F). Correlations also shown between fibrinogen concentration and MCF for ExTEM (G) and MCF for FibTEM (H). ** = p <0.01.</p

Correlations between aPTT and anti-FXa at varying concentrations of enoxaparin and tinzaparin, using various reagents.

<p>Anti-FXa activity reflects the concentration of LMWH and the aPTT correlated well to this measure. The correlation for Hemochron Jr is slightly weaker than for the other reagents (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.t002" target="_blank">Table 2</a>).</p

A comparison of enoxaparin and tinzaparin’s relative effects on aPTT.

<p>Bland-Altman plot showing that the aPTT’s induced by tinzaparin ranged from on average 49% more than enoxaparin (when measured using the PTT-Automat reagent) to 66% more than enoxaparin (when measured using the MRX931 reagent (FOR: free oscillation rheometry).</p

Relationship between measured anti-FXa and the concentration of low molecular weight heparin (LMWH).

<p>There is a strong linear correlation between anti-FXa results and the concentration of LMWH (dosed in anti-FXa units per ml). For enoxaparin and tinzaparin the correlation coefficients R_s are 0.97 and 0.96 respectively.</p

Boxplots of the four aPTT methods’ results for enoxaparin and tinzaparin in three different concentrations.

<p>When comparing the contiguous groups with the same aPTT-method but different concentrations of LMWH, a significant difference in aPTT was found in all cases. Statistical significances between classes are shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0116835#pone.0116835.s001" target="_blank">S1 File</a>.</p

Routine laboratory assay variables and POC assay variables in patients with or without DIC.

<p>Routine laboratory assay variables and POC assay variables in patients with or without DIC.</p