PREPARATION AND EVALUATION OF POLYMERIC NANOPARTICLES OF GLIBENCLAMIDE

Simple, reliable and reproducible method was used for the preparation of polymeric nanoparticles of Glibenclamide. The formulation was prepared by solvent evaporation method using magnetic stirrer with overnight stirring and the same was then evaluated for its particle size, drug content and in vitro dissolution studies. The above mentioned method showed similar particle size and exhibited an improvement in the drug entrapment efficiency. The ultraviolet spectrophotometric method was used to analyze Glibenclamide at 300 nm in different buffers. The study demonstrated the successful preparation of sustained release polymeric nanoparticles of Glibenclamide. Keywords: Glibenclamide, polymeric nanoparticles, solvent evaporatio

COMPRITOL® 888 LIPID MATRIX VIA TWIN SCREW EXTRUDER

Objective: The objective of this research was to explore the potential of Hot Melt Extrusion (HME) technique by using theophylline as the model drug to produce sustained release tablets utilizing Compritol®888 ATO as the retarding material and to study the influence of lipid: excipient ratio, excipient type as well as the processing conditions of the extruder on the release profile.Methods: The tablets prepared using hot fusion method was compared to the ones concocted by the HME technology. During the HME process, a powder mixture of moisture-free drug, lipid, and other adjuncts was introduced into the extruder and liquefied inside the barrel of the extruder. The in vitro dissolution studies of the formulations were carried out in pH 7.2 buffer using USP Apparatus 2. The extrudates were characterized via differential scanning calorimetry.Results: Comparing the two methods of processing, it was observed by the dissolution studies using phosphate buffer pH 7.2, that the tablets prepared by Hot Melt Extrusion method had a higher extent of release where all 3 formulations crossed 80% at the 8-hour mark, whereas the tablets prepared by hot fusion method did not show such consistency.Conclusion: This study demonstrated the fact that Compritol®888 ATO is a suitable waxy material that can be used as a matrix-forming agent to control the release of theophylline using the Hot Melt Extrusion process

Stabilization of the DMSO solvate of 2‑chloro‑5‑nitrobenzoic acid (mesalazine impurity M) by bifurcated hydrogen bonds: crystallographic, spectroscopic, thermal and computational Studies

The strategy for choosing the optimal solvent DMSO to produce the solvate of Mesalazine impurity M is demonstrated and the possibility of selective crystallization as a means to remove the impurity from the drug substance is proposed. The single crystal XRD was undertaken to identify molecular interactions that take place to compensate for the unsatisfied arrangement of hydrogen bonds in the supramolecular architecture. Interestingly, formation of O–H⋯S, O–H⋯O, and C–H⋯O connections leads to loop/ring motifs stabilizing the crystal entity. In the present study, purification of the drug molecule remains a chief objective for future investigations, since crystallization of Mesalazine impurity M alone cannot conclusively guarantee separation of impurity