Effect of combination feeding of Nannochloropsis and freshwater Chlorella on the fatty acid composition of rotifer Brachionus plicatilis in a continuous culture

金沢大学大学院自然科学研究科 信頼性システム工学A continuous culture of rotifer was conducted to investigate the effect of combination feeding of both a high density of Nannochloropsis oculata (N) and condensed freshwater Chlorella (FC) on the fatty acid composition of L-type rotifer Brachionus plicatilis in a continuous culture system. The algal feeding of the rotifers was carried out in three successive steps: N-feeding → N+FC-feeding → FC-feeding. The culture was conducted at 24°C and 25-27 psu in a 2000 mL bottle with 50% of water exchanged daily. The combination N+FC-feeding was effective in increasing rotifer density. The rotifers fed on N+FC (N+FC-R) had more non-polar lipids than polar ones, similar to those on N (N-R), opposite to the rotifers fed on FC (FC-R). N+FC-R contained higher levels of 16:2, 18:2n-6 (linoleic acid [LA]) and 20:2n-6, but lower levels of 18:1, 20:4n-6 (arachidonic acid), 20:5n-3 (eicosapentaenoic acid [EPA]) and 22:5n-3 (docosapentaenoic acid [DPA]) compared with N-R. Whereas N+FC-R contained higher levels of 16:1n-7, EPA and DPA, but lower levels of 16:2 and LA compared with FC-R. N+FC-R had more DPA in polar lipids than in non-polar ones. The Σn-6/Σn-3 ratio in N+FC-R was 0.9-1.0, significantly different from those in N-R (0.4) and FC-R (6.6-8.4). Therefore, it is inferred that the fatty acid profile of the N+FC-R cultured in a continuous culture system was affected by both N and FC. Also, the combination N+FC-feeding may be effective in manipulating the Σn-6/Σn-3 ratio in continuously cultured rotifers. © 2008 Japanese Society of Fisheries Science

トクシマ コウケツアツ トウニョウビョウ study : コウケツアツ トウニョウビョウ ガッペイレイ ニ カンスル リンショウテキ ケントウ

Hypertension is frequently complicated by diabetes mellitus and vice versa. Since these ２ disorders are important risk factors for atherosclerotic cardiovascular diseases, appropriate disease control is required. To understand the present state of treatment, we investigated hypertensive patients complicated by diabetes mellitus and vice versa who were under treatment by cardiology and diabetes specialists in Tokushima Prefecture, and evaluated the details of treatment and the state of disease control. The subjects consisted of １８２ hypertensive patients complicated by diabetes mellitus （Group C） who were under treatment by cardiology specialists and ２０５ diabetic patients complicated by hypertension （Group D） who were under treatment by diabetes specialists. When patient backgrounds were evaluated, patient age and BMI were significantly higher in Group C than in Group D, although HbA１c levels were significantly higher in Group D than in Group C. Calcium antagonists were most frequently used for the treatment of hypertension in both groups （７０．９％ in Group C and ６５．４％ in Group D）, and the percentage of patients who were treated with β‐blockers was significantly higher in Group C than in Group D （２８．６％ in Group C vs.８．８％ in Group D, p＜０．０００５）. The percentage of patients who fulfilled the criteria of blood pressure recommended by the Guidelines for the Management of Hypertension （JSH２０００） was ２１．６％ in Group C and ２２．９％ in Group D. When the type of antidiabetics was investigated, SU derivatives were most frequently used for the treatment of diabetes mellitus in both groups （４７．２％ in Group C and ５０．２％ in Group D, n.s.）, followed by the use of α‐GI, insulin, and biguanide in descending order. The percentage of patients who were treated with those types of antidiabetics did not significantly differ between the two groups. The percentage of patients who showed HbA１c levels below ６．５％ was significantly higher in Group C than in Group D （４０．７％ in Group C vs．２１．９％ in Group D p＜０．００５）. However, the percentage of patients who showed HbA１c levels of ８．０％ or higher was significantly higher in Group D than in Group C （１８．９％ in Group C vs. ３６．８％ in Group D, p＜０．０００１）. In addition, the percentage of patients in whom total cholesterol levels were successfully controlled based on the Guidelines for Diagnosis and Treatment of Atherosclerotic Cardiovascular Diseases （JAS２００２） did not significantly differ between the two groups （４９．７％ in Group C vs. ４５．０％ in Group D）. These findings suggest that the group at high-risk of atherosclerosis, such as hypertensive patients complicated by diabetes mellitus and vice versa, is not successfully managed. Therefore, more appropriate disease control is required in the future

A Steady Operation of n-Type Organic Thin-Film Transistors with Cyano-Substituted Distyrylbenzene Derivative

A novel n-type organic semiconductor, cyano-substituted distyrylbenzene derivative, 1,4-bis2-[4-(trifluoromethyl)phenyl]acrylonitorilebenzene, was synthesized by Knoevenagel condensation with aldehyde and acetonitrile derivatives. Fabricated thin-film transistors (TFTs) exhibited high electron field-effect mobility of 10-2?10-1 cm2 V-1 s-1, on/off current ratio of 6×105. Hysteresis-free n-type transport characteristics observed in this device promises a steady operation of organic logic circuit. Almost same TFT characteristic was observed even after 1 month storage in ambient condition. The findings indicate that the material has a good resistance to atmospheric oxidants

Meckel憩室内に発生した小腸カルチノイドの一例

京都府立医科大学附属北部医療センター　外科京都府立医科大学　消化器外科Department of Surgery, North Medical Center Kyoto Prefectural University of MedicineDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine症例は69歳男性。某年1月に右下腹部痛を主訴に当院救急を受診し感染性腸炎の診断で入院となった。精査で炎症を伴う小腸腫瘍を指摘され、異所性膵による膵炎の診断で腹腔鏡補助下小腸部分切除術を施行した。術中、回腸末端から55cm 口側の回腸漿膜下に突出した腫瘍を認めた。病理組織学的検査の結果、Meckel憩室内カルチノイド（NET G1）と診断した。小腸腫瘍はMeckel憩室も鑑別にあがるが、今回我々はMeckel憩室内カルチノイドを合併する稀な症例を経験したので報告する

胆嚢十二指腸瘻による胆石性イレウスの一例

京都府立医科大学附属北部医療センター　外科京都府立医科大学　消化器外科Department of Surgery, North Medical Center Kyoto Prefectual University of MedicineDivision of Digestive Surgery, Department of Surgery, Kyoto Prefectual University of Medicine症例は60歳、男性。腹痛・嘔気を主訴に近医から当院受診となった。CTでは小腸内に結石を認めており、その口側腸管の拡張を認めていたことから胆石性イレウスの診断となった。イレウス管留置を行い保存的加療を継続していたが嘔吐、腹痛ともに改善せず、当院外科で腸閉塞解除術を施行した。術中所見では腸管壊死は認めなかったため結石摘出術のみを施行し閉腹した。高度肥満に対する減量指導を行いながら外来で経過観察し、胆嚢十二指腸瘻閉鎖術を二期的に行う方針となっている