ラットの外因性高コレステロール血症発症の機作とその改善に関する研究

第I章 序論 第II章 高コレステロール血症発症の機作 第III章 高コレステロール血症発症に及ぼす食事脂肪の影響 第IV章 ペルオキシソームプロリファレーターによる高コレステロール血症の改府 第V章 高コレステロール血症発症に関与する遺伝子の検索 第VI章 総括Made available in DSpace on 2012-09-06T04:29:27Z (GMT). No. of bitstreams: 2 nagao1.pdf: 10875730 bytes, checksum: 931f6af4d2d07e39034809541d17d212 (MD5) nagao2.pdf: 10398073 bytes, checksum: a27cbe47c8bb57e006fc5bf87af4b853 (MD5) Previous issue date: 1998-03-27主1-参

Rectal Carcinoma with Heterotopic Bone: Report of a Case

Heterotopic bone is rarely present in malignant tumors of the gastrointestinal tract. We herein report a case of rectal adenocarcinoma with heterotopic bone. A 46-year-old Japanese male presented to our hospital with abdominal distension and constipation. Colonoscopic examination showed an ulcerated polypoid tumor of the rectum which nearly obstructed the rectal lumen. Abdominal computed tomography showed a tumor of the rectum with calcified deposits. Low anterior resection with lateral lymph node dissection was performed under the tentative diagnosis of rectal cancer. Histological examination of the resected specimen showed mucinous carcinoma of the rectum with heterotopic bone. One of the metastatic lymph nodes dissected also showed heterotopic bone. In the present report, we describe this rare tumor and briefly review the pertinent literature regarding rectal cancer with heterotopic bone

Taurine reduces the secretion of apolipoprotein B100 and lipids in HepG2 cells

<p>Abstract</p> <p>Background</p> <p>Higher concentrations of serum lipids and apolipoprotein B100 (apoB) are major individual risk factors of atherosclerosis and coronary heart disease. Therefore ameliorative effects of food components against the diseases are being paid attention in the affluent countries. The present study was undertaken to investigate the effect of taurine on apoB secretion and lipid metabolism in human liver model HepG2 cells.</p> <p>Results</p> <p>The results demonstrated that an addition of taurine to the culture media reduces triacylglycerol (TG)-mass in the cells and the medium. Similarly, cellular cholesterol-mass was decreased. Taurine inhibited the incorporation of [¹⁴C] oleate into cellular and medium TG, suggesting the inhibition of TG synthesis. In addition, taurine reduced the synthesis of cellular cholesterol ester and its secretion, suggesting the inhibition of acyl-coenzyme A:cholesterol acyltransferase activity. Furthermore, taurine reduced the secretion of apoB, which is a major protein component of very low-density lipoprotein.</p> <p>Conclusion</p> <p>This is a first report to demonstrate that taurine inhibits the secretion of apoB from HepG2 cells.</p

Detection of Polarized Broad Emission in the Seyfert 2 Galaxy Mrk 573

We report the discovery of the scattered emission from a hidden broad-line region (BLR) in a Seyfert 2 galaxy, Mrk 573, based on our recent spectropolarimetric observation performed at the Subaru Telescope. This object has been regarded as a type 2 AGN without a hidden BLR by the previous observations. However, our high quality spectrum of the polarized flux of Mrk 573 shows prominent broad (~3000 km/s) H_alpha emission, broad weak H_beta emission, and subtle Fe II multiplet emission. Our new detection of these indications for the presence of the hidden BLR in the nucleus of Mrk 573 is thought to be owing to the high signal-to-noise ratio of our data, but the possibility of a time variation of the scattered BLR emission is also mentioned. Some diagnostic quantities such as the IRAS color, the radio power, and the line ratio of the emission from the narrow-line region of Mrk 573 are consistent with the distributions of such quantities of type 2 AGNs with a hidden BLR. Mrk 573 is thought to be an object whose level of the AGN activity is the weakest among the type 2 AGNs with a hidden BLR. In terms of the systematic differences between the type 2 AGNs with and without a hidden BLR, we briefly comment on an interesting Seyfert 2 galaxy, Mrk 266SW, which may possess a hidden BLR but has been treated as a type 2 AGNs without a hidden BLR.Comment: 9 pages including 6 figures, to appear in The Astronomical Journa

Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

Funding Information: We thank K. Murakami, H. Kimura, H. Kurumizaka, and J.M. Stark for materials. This work was supported by JSPS KAKENHI grant nos. JP19H03156 , JP18H04713 , JP18H05532 , and JP25116004 (to C.O.), JP17H06426 (to K.N.), JP18H04900 and JP19H04267 (to H.S.), the Mitsubishi Foundation (to H.S.), and by Cancer Research UK awards C1445/A19059 and DRCPGM/100013 (to S.H. and A.D.D. lab). Publisher Copyright: © 2021 The Author(s)Peer reviewedPublisher PD

Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF Rats

Conjugated fatty acid, the general term of positional and geometric isomers of polyunsaturated fatty acids with conjugated double bonds, has attracted considerable attention because of its potentially beneficial biological effects. In the present study, dietary effect of pomegranate seed oil rich in punicic acid (9cis, 11trans, 13cis-conjugated linolenic acid; 9c, 11t, 13c-CLNA) on lipid metabolism was investigated in obese, hyperlipidemic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. After 2 weeks feeding period, OLETF rats revealed obesity and hyperlipidemia compared with their progenitor LETO rats. Feeding of the diet supplemented with 9% safflower oil and 1% pomegranate seed oil (9c, 11t, 13c-CLNA diet) did not affect abdominal white adipose tissue weights and serum lipid levels compared with the diet supplemented with 10% safflower oil (control diet) in OLETF rats. However, the accumulated hepatic triacylglycerol was markedly decreased by 9c, 11t, 13c-CLNA diet in OLETF rats. Activities of hepatic enzymes related to fatty acid synthesis and fatty acid β-oxidation were not altered by 9c, 11t, 13c-CLNA diet. Levels of monounsaturated fatty acid (MUFA), major storage form of fatty acid, in serum triacylglycerol were markedly higher in obese, hyperlipidemic OLETF rats than in lean LETO rats. In addition, 9c, 11t, 13c-CLNA diet significantly decreased MUFA levels in OLETF rats. This is the first study showing that 9c, 11t, 13c-CLNA suppresses delta-9 desaturation in vivo, and we suggest that the alleviation of hepatic triacylglycerol accumulation by 9c, 11t, 13c-CLNA diet was, at least in part, attributable to the suppression of delta-9 desaturation in OLETF rats

Prompt and Long-term Prophylactic Effect of Closed Loop Stimulation against Paroxysmal Atrial Fibrillation in a Patient with Sick Sinus Syndrome

A 72-year-old woman with sick sinus syndrome (SSS), who had frequent paroxysmal atrial fibrillations (PAfs) and normal cardiac function, was admitted to our hospital due to syncope. PAfs frequently occurred during the first week after DDD pacemaker implantation (PMI), with closed loop stimulation (CLS) rate-adaptive mode off, but were completely suppressed during the second week, with CLS on, and had been well-controlled over three years thereafter. However, PAfs occasionally occurred under intense sympathetic activity during 6 months after PMI as well, and were effectively terminated by disopyramide which had anticholinergic effect. Thus, the development and maintenance of PAf were thought to be associated with destabilized cardiac autonomic activities, that is, sympathetic and parasympathetic dominance, respectively. Additionally, heart rate variability analyses after implementation of CLS revealed the restoration of sympathetic and parasympathetic components. Accordingly, CLS mode was considered to play a critical role in preventing PAf by reflecting autonomic activity in heart rhythm in this SSS patient