Anatomical and Functional Localisation of the Trigeminal Ganglion.

<p>(left) High resolution axial T2-weighted image illustrates Meckel's cave (magenta), the anatomical location of the trigeminal ganglion. (right) Post-surgical rCBF increases in trigeminal ganglion.</p

Within-scanner time courses of VAS indices of (a) perceived alertness and (b) pain experienced pre/post each pCASL scan.

<p>Each visit is plotted separately (Left tooth  =  Grey, Right Tooth  =  White; Filled circles =  Post-surgical visit, Unfilled circles  =  Pre-surgical visit; Error bars indicate ±1 Standard Deviation.</p

Additional regions of increased post-surgical CBF not specified <i>a priori</i> to underpin central processing of pain.

<p>Additional regions of increased post-surgical CBF not specified <i>a priori</i> to underpin central processing of pain.</p

(a–f) Time courses of post-surgical rCBF increases relating to pain in each a priori-defined ROI.

<p>Cluster-corrected (p<0.05) Z-statistic map (red) indicates regional post-surgical increases in CBF relating to pain. In each row, <i>a priori</i> ROI masks are outlined in yellow. Plots at far right of each row indicate time courses of post-surgical increases in CBF (ml/100 g/min) for each ROI extracted from each individual pCASL scan (Red  =  left hemisphere, Blue  =  right hemisphere; Error bars represent ±1 Standard Error).</p

Regions of increased post-surgical CBF specified <i>a priori</i> to underpin cerebral processing of pain.

<p>Regions of increased post-surgical CBF specified <i>a priori</i> to underpin cerebral processing of pain.</p

Post-surgical CBF changes in S1 relate to the classical somatotopic representation of the jaw (adapted from [<b>48</b>]).

<p>CBF increases coded in red illustrates mask image of clusters significant at the p<0.05 (corrected) level. Yellow mask illustrates S1 ROI in left and right cerebral hemispheres.</p

ROI Analysis summary table.

<p>(Columns, left to right) ROI; Mean rCBF values from pre- and post-surgical sessions on left [L] and right [R] teeth; Mean rCBF difference between pre and post-surgical sessions; F-statistic and associated p-value for main effect of Surgery (ROIs significant after Bonferroni correction illustrated by an asterisk); comparison of rCBF differences between post-surgical sessions following left and right TME and associated F-statistic and p-value; F-statistic and associated p-value for rCBF differences between left and right cerebral hemispheres.</p