A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells

Background: In recent years the use of low-power lasers has been widely used in medicine. With the introduction of affordable LED light, clinical application of LED light has become more and more popular. However, some researchers believe that because of the lack of coherence of the LED light, it can be different   in biological effects in comparison to laser. In this study, we compared the biological effects of low level laser to those of LED light. Methods: Human skin fibroblast cell line Hu02 was irradiated with low level laser and LED light with a wavelength of 660 nm, power output of 35 mW and in continuous mode and the control group was not irradiated.  The biological effects were compared through the analyzing of cell proliferation, production of reactive oxygen species within the cell and the rate of cell division.Results: Our findings showed that production of reactive oxygen species within the cell was linearly increased both in the LED and laser light irradiated cells. However, laser light is more increment in comparison the LED light. The MTT results showed that laser light at low energy density (less than 5 joules per square centimeter) was increased the rate of cell proliferation after 24 hours. Although, the rate of cell division was increased in energy density of 1 J/cm2 compared to the control group, but this increasing was not statistically significant.Discussion: The findings indicated that the coherence properties of laser light provided more energy for the cells, and in a constant energy density, laser light created more oxidative stresses in compared with LED light.

Supervised Deep Learning for Content-Aware Image Retargeting with Fourier Convolutions

Image retargeting aims to alter the size of the image with attention to the contents. One of the main obstacles to training deep learning models for image retargeting is the need for a vast labeled dataset. Labeled datasets are unavailable for training deep learning models in the image retargeting tasks. As a result, we present a new supervised approach for training deep learning models. We use the original images as ground truth and create inputs for the model by resizing and cropping the original images. A second challenge is generating different image sizes in inference time. However, regular convolutional neural networks cannot generate images of different sizes than the input image. To address this issue, we introduced a new method for supervised learning. In our approach, a mask is generated to show the desired size and location of the object. Then the mask and the input image are fed to the network. Comparing image retargeting methods and our proposed method demonstrates the model's ability to produce high-quality retargeted images. Afterward, we compute the image quality assessment score for each output image based on different techniques and illustrate the effectiveness of our approach.Comment: 18 pages, 5 figure

Sensor Fault Detection and Compensation with Performance Prescription for Robotic Manipulators

This paper focuses on sensor fault detection and compensation for robotic manipulators. The proposed method features a new adaptive observer and a new terminal sliding mode control law established on a second-order integral sliding surface. The method enables sensor fault detection without the need to impose known bounds on fault value and/or its derivative. It also enables fast and fixed-time fault-tolerant control whose performance can be prescribed beforehand by defining funnel bounds on the tracking error. The ultimate boundedness of the estimation errors for the proposed observer and the fixed-time stability of the control system are shown using Lyapunov stability analysis. The effectiveness of the proposed method is verified using numerical simulations on two different robotic manipulators, and the results are compared with existing methods. Our results demonstrate performance gains obtained by the proposed method compared to the existing results

Mathematical Model and Meta-Heuristic Algorithm for Dual Resource Constrained Hybrid Flow-Shop Scheduling Problem with Job Rejection

In the real world, firms with hybrid flow-shop manufacturing environment generally facethe human resource constraint, salary cost increasment and efforts to make better use oflabor, in addition to machine constraint. Given the limitations of these resources, productdelivery requierements to customers have made the job rejection essential in order to meetdistinct customer requirements. Therefore, this research has studied the dual resourceconstrained hybrid flow-shop scheduling problem with job rejection in order to minimizethe total net cost (the sum of the total rejection cost and the total tardiness cost of jobs)which is widely used in many industries. In this article, a mixed integer linear programmingmodel has developed for the research problem. In addition, an improved sooty ternoptimization algorithm (ISTOA) has proposed to solve the large-sized problems as well asa decoding method due to the NP-hardness of the problem. In order to evaluate theproposed optimization algorithm, five well-known algorithms in the literature including(immunoglobulin-based artificial immune system (IAIS), genetic algorithm (GA), discreteartificial bee colony (DABC), improved fruit fly optimization (IFFO), effective modifiedmigrating birds optimization (EMBO)) have adapted with the proposed problem. Finally,the performance of the proposed optimization algorithm has investigated against theadapted algorithms. Results and evaluations show the good performance of the improvedsooty tern optimization algorithm

The Role of N-Acetylcysteine in Platelet Aggregation and Reperfusion Injury in Recent Years

Introduction: N-acetylcysteine (NAC) is an amino acid that contains a cysteine group and is currently used widely in various fields of medical research especially in cardiology. In this review, potential benefits of NAC in the aggregation of platelet and reperfusion injury are evaluated. Methods and Results: The available evidence was collected by searching Scopus, Pub-Med, Medline, Cochrane central register of controlled trials, and Cochrane database systematic reviews. Our searching was performed without time limitation and only English language articles were included in this review. Key words used as search terms included “N-acetylcysteine”, “platelet aggregation”, “reperfusion injury”. Over the past decade, several investigations were carried out to ascertain reperfusion injury and antiplatelet properties of NAC, and in this article the results of investigations in both models (human and animal) were addressed in details. The results revealed that NAC has an important antiplatelet property in animal models while this effect is not very significant in human models and needs more investigations. However, its reperfusion injury in both models is worth noticing. Conclusions: Due to the limited data about effectiveness of NAC in both human and animal as antiplatelet agent, more investigation is needed to evaluate NAC efficacy in platelet aggregation and reperfusion injury especially in human studies in the future

Evaluation of Suitability Groundwater Quality for Agricultural, Drinking and Industrial Purposes (Case Study: South of Chaharmahal and Bakhtiari Province)

The significant reduction of surface water resources and recent recurrent droughts have increased the reliance on groundwater sources, leading to a decline in their quality. In this study, 28 samples of well water from different locations in Khanmirza, Lordegan, Borujen, Ardal and Kiar were collected in 2020-2021 and underwent chemical analysis in the laboratory. To evaluate the quality of the samples for use in agricultural, drinking and industrial sectors, the Wilcox diagram, Schuler diagram and Langlier index were used. Using interpolation methods, the chemical properties of the samples taken within the study area were examined and qualitative zoning maps were prepared using Kriging and inverse distance weighting methods. The results showed that according to the Wilcox diagram, most of the samples are within the range of C2S1 and are suitable for agricultural purposes. According to the Schuler diagram, these samples are within the range of good quality for drinking and based on the Langlier index, they are within the range of precipitating and consumable. This study helps decision-makers to have a clear view and plan comprehensively and effectively for the exploitation and preservation of groundwater resources, taking into account the qualitative maps of groundwater

Delay-Dependent Stability Region for the Distributed Coordination of Delayed Fractional-Order Multi-Agent Systems

Delay and especially delay in the transmission of agents’ information, is one of the most important causes of disruption to achieving consensus in a multi-agent system. This paper deals with achieving consensus in delayed fractional-order multi-agent systems (FOMAS). The aim in the present note is to find the exact maximum allowable delay in a FOMAS with non-uniform delay, i.e., the case in which the interactions between agents are subject to non-identical communication time-delays. By proving a stability theorem, the results available for non-delayed networked fractional-order systems are extended for the case in which interaction links have nonequal communication time-delays. In this extension by considering a time-delay coordination algorithm, necessary and sufficient conditions on the time delays and interaction graph are presented to guarantee the coordination. In addition, the delay-dependent stability region is also obtained. Finally, the dependency of the maximum allowable delay on two parameters, the agent fractional-order and the largest eigenvalue of the graph Laplacian matrix, is exactly determined. Numerical simulation results are given to confirm the proposed methodologies

The Effectiveness of Intravenous lidocaine in Burn Pain Relief: A Randomized Double-Blind Controlled Trial

Objectives: Poor pain control in burn patients as a great public health problem disrupts the healing and rehabilitation process and results in several adverse outcomes. The aim of this study was to investigate the efficacy and safety of intravenous lidocaine in reducing the pain of burn injuries. Materials and Methods: From August 2014 to March 2015, 66 eligible burn patients participated in the study and were randomly divided into two groups of lidocaine (L) and placebo (P). In group L, lidocaine 2% was injected at a bolus dose of 1.5 mg/kg followed by infusion at the dosage of 1.5 mg/kg/h, and in group P, saline was administrated. Pain severity was measured during 24 hours at baseline and 1, 2, 4, 8, 12, 16, 20, 24 hours after intervention based on Numerical Rating Scale (NRS-11). Morphine consumption, Ramsay score, and side effects were also documented. Results: Finally the data from 60 patients were analyzed. Comparing baseline with 24 hours after intervention, NRS-11 scores decreased from 7.12±1.42 to 3.33±0.76 (P<0.001) in group P and from 6.45±1.02 to 2.50±0.72 (P<0.001) in group L. Moreover, the mean of NRS scores during 24 hours in the lidocaine group was significantly lower compared to the placebo group, 3.93±0.72 vs 4.73 ±1.14, (P=0.03). The mean amounts of morphine consumption in group L were significantly lower compared to group P, 14.41 ± 4.86 vs 21.07±6.86, (P=0.001). The mean of Ramsay score in group L was significantly lower compared to group P, 1.38±0.59 vs 1.45±0.6, (P=0.014). Conclusions: This study revealed that intravenous lidocaine was an effective and safe drug for pain reduction in burn patients

Comparison among Ocular Response Analyzer, Corvis ST and Goldmann applanation tonometry in healthy children

AIM: To explore the relationship between different parameters of Ocular Response Analyzer (ORA) and Corvis ST (CST) in a sample of healthy Iranian school-aged children and the relationship between parameters of these 2 instruments against intraocular pressure (IOP), measured by the Goldmann applanation tonometer (GAT-IOP), age and gender, and find possible correlation between ORA and CST with GAT. METHODS: This cross-sectional study included 90 healthy children. A general interview and complete eye examination were performed. Following successful GAT-IOP measurement, ORA and CST were conducted. The CST parameters were A 1/2 length (A1L, A2L), A 1/2 velocity (A1V, A2V), highest concavity deformation amplitude (HCDA), radius of curvature (RoC), peak distance (PD), central corneal thickness (CCT) and IOP. The ORA parameters were corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated IOP (IOP-G) and corneal compensated IOP (IOP-CC). Extracted data was analyzed using the Statistical Package for Social Science software. RESULTS: Totally 39 males with age of 9.08±1.60 (6-12)y and 51 females with age of 8.96±1.55 (6-13)y were included. Many CST parameters were significantly correlated with CH, CRF, IOP-G and IOP-CC. Some CST parameters had a significant correlation with GAT-IOP, including IOP-CST in both eyes and HCDA, A2L, PD, and RoC in the left eye, but none with age, except A2L in the right eye. The CRF measurement showed a significant correlation with GAT-IOP in both eyes and CH in the right eye, yet, none with age. Among all CST and ORA parameters, CCT-CST in both eyes and A1L in right eye had a significant correlation with gender, although this was a negligible negative correlation. Comparison of mean IOP values by different devices showed a significantly highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Also, IOP-G versus IOP-CST significantly had the lowest IOP overestimation among others. Overall, either low positive correlation or negligible correlation was found between IOP measurements by 3 instruments. CONCLUSION: The study finds the highest IOP overestimation by CST and lowest by IOP-CC compared with GAT. Overall, either low positive correlation or negligible correlation is found between IOP measurements by the 3 instruments

A comparison of oral omeprazole and intravenous cimetidine in reducing complications of duodenal peptic ulcer

BACKGROUND: Gastrointestinal bleeding is a common problem and its most common etiology is peptic ulcer disease. Ulcer rebleeding is considered a perilous complication for patients. To reduce the rate of rebleeding and to fasten the improvement of patients' general conditions, most emergency departments in Iran use H2-blockers before endoscopic procedures (i.e. intravenous omeprazole is not available in Iran). The aim of this study was to compare therapeutic effects of oral omeprazole and intravenous cimetidine on reducing rebleeding rates, duration of hospitalization, and the need for blood transfusion in duodenal ulcer patients. METHODS: In this clinical trial, 80 patients with upper gastrointestinal bleeding due to duodenal peptic ulcer and endoscopic evidence of rebleeding referring to emergency departments of Imam and Sina hospitals in Tabriz, Iran were randomly assigned to two equal groups; one was treated with intravenous cimetidine 800 mg per day and the other, with 40 mg oral omeprazole per day. RESULTS: No statistically significant difference was found between cimetidine and omeprazole groups in regards to sex, age, alcohol consumption, cigarette smoking, NSAID consumption, endoscopic evidence of rebleeding, mean hemoglobin and mean BUN levels on admission, duration of hospitalization and the mean time of rebleeding. However, the need for blood transfusion was much lower in omeprazole than in cimetidine group (mean: 1.68 versus 3.58 units, respectively; p < 0.003). Moreover, rebleeding rate was significantly lower in omeprazole group (15%) than in cimetidine group (50%) (p < 0.001). CONCLUSION: This study demonstrated that oral omeprazole significantly excels intravenous cimetidine in reducing the need for blood transfusion and lowering rebleeding rates in patients with upper gastrointestinal bleeding. Though not statistically significant (p = 0.074), shorter periods of hospitalization were found for omeprazole group which merits consideration for cost minimization