Efficient evaluation of range queries over spatial data by clients

The notion of Geometrically Searchable Encryption, and anticipated an effectual scheme, named FastGeo, to keep the privacy of clients’ spatial datasets kept and enquired at a public server. With FastGeo, which is a novel two-level search for scrambled spatial data, an honest-but-curious server can proficiently complete geometric range queries, and suitably return data points that are private a geometric range to a client without culture penetrating data points or this cloistered query. FastGeo wires arbitrary geometric areas, accomplishes sub linear search time, and qualifies go-ahead updates over encrypted spatial datasets. Our outline is provably sheltered, and our new results on real-world spatial datasets in cloud platform determine that FastGeo can enhance search time over 100 times

Efficient access control technique to maintain health records in cloud

We propose a novel attribute based encryption scheme for fine-grained and adaptable access control to PHRs information in cloud computing. The plan creates shared information by the normal access subpolicy which depends on various patients' entrance arrangements. At that point the plan joins the encryption of PHRs from various patients. Hence, both time utilization of encryption and decryption can be diminished. Medical staff require changing dimensions of access to PHRs. The proposed plan can likewise bolster multi-benefit get to control with the goal that therapeutic staff can get to the required dimension of information while augmenting quiet security. Through usage and reenactment, we show that the proposed plan is effective regarding time. In addition, we demonstrate the security of the proposed plan dependent on security of the ciphertext-strategy attribute based encryption scheme

Fairness Testing: Testing Software for Discrimination

This paper defines software fairness and discrimination and develops a testing-based method for measuring if and how much software discriminates, focusing on causality in discriminatory behavior. Evidence of software discrimination has been found in modern software systems that recommend criminal sentences, grant access to financial products, and determine who is allowed to participate in promotions. Our approach, Themis, generates efficient test suites to measure discrimination. Given a schema describing valid system inputs, Themis generates discrimination tests automatically and does not require an oracle. We evaluate Themis on 20 software systems, 12 of which come from prior work with explicit focus on avoiding discrimination. We find that (1) Themis is effective at discovering software discrimination, (2) state-of-the-art techniques for removing discrimination from algorithms fail in many situations, at times discriminating against as much as 98% of an input subdomain, (3) Themis optimizations are effective at producing efficient test suites for measuring discrimination, and (4) Themis is more efficient on systems that exhibit more discrimination. We thus demonstrate that fairness testing is a critical aspect of the software development cycle in domains with possible discrimination and provide initial tools for measuring software discrimination.Comment: Sainyam Galhotra, Yuriy Brun, and Alexandra Meliou. 2017. Fairness Testing: Testing Software for Discrimination. In Proceedings of 2017 11th Joint Meeting of the European Software Engineering Conference and the ACM SIGSOFT Symposium on the Foundations of Software Engineering (ESEC/FSE), Paderborn, Germany, September 4-8, 2017 (ESEC/FSE'17). https://doi.org/10.1145/3106237.3106277, ESEC/FSE, 201

Hit Refresh

xv, 360 hlm.; 21 x 13 c

Identification of New Molecular Entities (NMEs) as Potential Leads against Tuberculosis from Open Source Compound Repository.

The purpose of this study was to provide a number of diverse and promising early-lead compounds that will feed into the drug discovery pipeline for developing new antitubercular agents. The results from the phenotypic screening of the open-source compound library against Mycobacterium smegmatis and Mycobacterium bovis (BCG) with hit validation against M. tuberculosis (H37Rv) have identified novel potent hit compounds. To determine their druglikeness, a systematic analysis of physicochemical properties of the hit compounds has been performed using cheminformatics tools. The hit molecules were analysed by clustering based on their chemical finger prints and structural similarity determining their chemical diversity. The hit compound library is also filtered for druglikeness based on the physicochemical descriptors following Lipinski filters. The robust filtration of hits followed by secondary screening against BCG, H37Rv and cytotoxicity evaluation has identified 12 compounds with potential against H37Rv (MIC range 0.4 to 12.5 μM). Furthermore in cytotoxicity assays, 12 compounds displayed low cytotoxicity against liver and lung cells providing high therapeutic index > 50. To avoid any variations in activity due to the route of chemical synthesis, the hit compounds were re synthesized independently and confirmed for their potential against H37Rv. Taken together, the hits reported here provides copious potential starting points for generation of new leads eventually adds to drug discovery pipeline against tuberculosis

The hit compounds were analyzed by Cytoscape and Chemmine for physicochemical parameters.

<p>Filtering compounds based Lipinski rule of five druglikeness (A) Molwt cutoff, (B) alogP (C) Hydrogen bond donors and (D) Hydrogen bond acceptors.</p

Complete analysis of data from screening for antitubercular activity and physico chemical properties of the hit compounds.

<p>Rifampicin and Isoniazid were taken as controls. MIC values for controls against <i>M</i>. <i>smegmatis</i> are Rif-2.43±0.02μM and Inh-11.03±0.05 μM and <i>H37Rv</i> are Rif-0.08±0.01μM and Inh-0.22±0.3 μM.</p

Work flow.

<p>Small molecule library screening for anti mycobacterial potential, physicochemical properties following medicinal chemistry principles and cytotoxicity identified potential hit scaffolds.</p