The Role of CCUS in North America Energy System Decarbonization

One of the key energy technologies that can significantly reduce carbon dioxide (CO2) emissions across industrial processes and power generation is carbon capture, utilization, and storage (CCUS). We explore different scenarios of North America long-term energy system development with respect to CCUS technologies and, particularly, CO2-enhanced oil recovery (EOR)

Morphological features of lymphatic microvessel density depending on stage of cervical neoplasia

Incomplete characterization of the uterine cervix cancer from molecular point of view represents the main problem for the use of a proper therapy in this disease. Few data are available about D2-40 expression in lymphatic endothelial cells and also in tumor cells from uterine cervix cancer. The aim of the present work was to study the involvement of lymphatics in tumor progression of the uterine cervix lesions. There were investigated targeted biopsies of the uterine cervix and specimens taken from conization in patients with macroscopically detectable lesions. We used D2-40 immunostaining to highlight lymphatic vessels from squamous cell metaplasia (n=17), cervical intraepithelial neoplasia (n=l 1), carcinoma in situ (n=3), microinvasive carcinoma (n=4) and invasive carcinoma (n=19) using Avidin-Biotin technique (LSAB+). Type and distribution of lymphatics in different lesions of the cervix were analyzed. Type and distribution of LVs(lymphatic vessels) in the normal uterine cervix. In the superficial lamina propria of the normal cervix, LVs were very rare and small or even absent. In all normal cases, LVs, if found, were located at some distance from the epithelium. In the deep lamina propria we noticed the presence of D2-40 positive vessels with density that ranged between 5 and 6.6 vessels/x200, with an average of 5.8. In the muscle layer, LMVD (lymphatic microvessel density) ranged between 5.3 and 7, with an average of 6.15. Type and distribution of LVs in precursor lesions. In squamous cell metaplasia the distribution and number of LVs was not significantly different from results found in the normal cervix. A significant increase in the number of LVs was found in cases with cervical intraepithelial neoplasia high-grade. In these cases, we noticed the presence of many LVs located close to the epithelium and was associated with a significantly increased expression of D2-40 in basal cells. LMVD in CIN ranged between 10.3 and 19.3 with an average of 14.8 vessels/x2005. Lymphatics in microinvasive and invasive carcinoma. Intratumoral LVs were found in both microinvasive and invasive carcinoma. Intratumoral LVs were very rare, small, with narrow lumen, irregular wall and without content of tumor cells. Peritumoral LVs were significantly more numerous, large, sinuous, and occasionally contained tumor cells. LMVD in cases with invasive carcinoma ranged from 0 to 12.3, with an average of 6.15. In microinvasive carcinoma, LMVD has values ranged between 3 and 11, with an average of 8.15. We found significant correlation between lymphatic microvessel density and tumor grade and particular distribution of the lymphatics linked to histopathologic type of the lesions. Our results showed differences in the distribution and D2-40 expression in lymphatic vessels and tumor cells from the cervix lesions linked to histopathology and tumor grade

Социокультурные характеристики аграрного сектора региона: неформальные институты, культурный код как драйвер развития и решения проблемы «колеи», практика измерения параметров.

The goal is to study the socio-cultural characteristics of society in the agro-industrial complex of the region, to determine cultural codes - both the driver of development and the "rut problem" caused by informal institutions and negative non-format practices. The problems of socio-economic modernization, informal institutions of the agrarian sector of the region's economy are considered. The analysis of methods for studying the relationship between organizational behavior and culture used in world practice is given. Based on the materials of the agrarian sector of the region, using the bipolar measurement methodology, the parameters of the existing organizational culture, which are a resource for the formation of social capital, affect the formation of an organizational climate that reflects the feelings and perception of the situation by employees, are investigated. The authors evaluated in aggregated indicators informal institutions and the course of modernization processes in the production sector of agriculture in the region. The work contains recommendations to the business community, municipal and regional authorities on regulating the processes of institutional development, reducing transaction cost

Культура как ресурс в модернизации аграрной экономики: измерение параметров, механизмы влияния на процессы преобразований

Objective: to study the influence of culture parameters on modernization processes in the agrarian sector of the economy. Object: modernization processes in society, the parameters of culture, social capital, the structure of transaction costs. The work contains recommendations to the business community, government and self-government bodies on regulation of modernization processes, institutional development

Rolul mastocidelor în progresia tumorală

Academic adviser: Vitalie Mazuru – Senior lecturer Department Histology, Cytology and Embriology State Medical and Pharmaceutical University “Nicolae Testemiţanu”The aim of this article is to show the key points regarding the crucial role of mast cells in supporting and promoting tumor progression. The article reveals important facts about both the immunosuppressive function of mast cells, that greatly enhances the tumor progression, as well as the changes in intercellular junctions induced by mast cell activity. Additionally, the article focuses on blood and lymphatic vessels growth provided by mast cell activity, an essential prerequisite necessary for tumor growth. Rolul mastocidelor în progresia tumorală Scopul acestui articol este de a prezenta momentele cheie privitor la rolul crucial al mastocitelor în promovarea progresiei tumorale. Articolul aduce informaţii importante atât despre funcţia imunosupresivă a mastocitelor, care considerabil duce la accelerarea progresiei tumorale, cât şi despre modificările joncţiunilor intercelulare induse de activitatea mastocitelor. Deasemenea, articolul descrie angiogeneza şi limfangiogeneza promovată de activitatea mastocitelor, o premisă necesară pentru creşterea tumorală

Inflammatory markers of hemorrhagic shock before and after resuscitation with NOS inhibitor - Difetur

Catedra Fiziopatologie şi fiziopatologie clinicăHemorrhagic shock (HS) leads to an exaggerated production of inflammatory mediators, such as cytokines and chemokines, which may play a significant role in the development of multiple organ failure (MOF) under those conditions. In HS the level of pro- and anti-inflammatory cytokines ( TNF α, IL-1, IL-6, IL-10) increases. Difetur inhibits iNOS induction, decreasing level of proinflammatory and antiinflammatory cytokines which may contribute to its inflammatory-reducing effects. Impactul hemoragic declanşează producerea exagerată de mediatori inflamatori aşa ca citokinele şi chemokinele cu rol semnificativ în dezvoltarea sindromului de disfuncţie poliorganică. În cadrul ŞH experimental creşte nivelul seric al citochinelor pro- şi antiinflamatoare (TNF α, IL-1, IL-6, IL-10). S-a stabilit că administrarea inhibitorului NO sintazei - Difetur conduce la micşorarea nivelului citokinemiei limitînd leziunile celulare şi ameliorînd funcţiile sistemelor de organe

Influence on Transaction Costs and Market Barriers of Organizational Behaviour and Culture of the Rural Population: Analysis and Research Practice

The purpose of this study is to study the parameters of the existing organizational culture in the agrarian sector as a resource for the formation of social capital and its impact on the formation of transaction costs, market barriers Methods / Statistical analysis. Analytical methods were used, such as sociological and expert interviews, content and problem-oriented analysis. The study of behavioral characteristics was based on Hofstede's parametric models adapted to agriculture. The methods we used were aimed at achieving the following goals: to identify the nature of the transaction costs of the agricultural sector, taking into account specific features on the ground, to identify the features of behavioral attitudes and values, the features of the cost structure within the regional institutional framework for interaction and analysis of cultural codes. Conclusions. Based on the materials of the agrarian sector of the regional economy, the parameters of the existing organizational culture were studied; specific features of transaction costs formed by the cultural component were identified; studies of cultural codes were conducted. The following features of the agrarian sector were revealed: excessive production cycle, uneven distribution of income during the year, dependence on natural and climatic conditions. The features described above indicate the need for state support and a well-developed communication system. A cluster of cultural components denotes a cultural code that reflects a high level of differentiation of roles between a man and a woman; the prevailing collective consciousness; the tendency to avoid situations of uncertainty and clearly established courses of action and rules; a low level of self-control and a low level of the need to meet basic needs. Specific transaction costs due to cultural determinants include the following: the costs of finding, processing and storing data, the costs of negotiations and contracts; coordination costs; the costs of politicization; the costs of making collective decisions; loss of profits. Application: The results presented can help solve the problem of over-coming informal institutional constraints, and can be applied to the de-velopment and accumulation of social capital, the introduction of better informal practices to reduce costs by eliminating lost profits, overcoming market barriers. improving the quality of the transactional sector of the economy as a whole

Studiul comparativ al expresiei osteoporozei la pacienţii cu artrită reumatoidă

Subiecţii au fost examinaţi clinico-paraclinic, cu aprecierea ulterioară a densităţii minerale osoase prin DXA. Pacienţii seropozitivi au un număr mai mare de articulaţii afectate. La pacienţii seronegativi s-a determinat o durată semnificativ mai crescută redorii matinale, cât frecvenţa mai crescută a cazurilor cu osteopenie şi osteoporoză. Dezvoltarea masei osoase maximale depinde de maladiile concomitente aşa ca artrita reumatoidă

Studiul vitaminei D la pacienţii cu artrită reumatoidă

Studiul s-a efectuat timp de un an, în care subiecţii au primit suplimente de vitamina D şi calciu, cu determinarea periodică markerilor metabolismului fosfo-calcic, cât şi a densităţii minerale osoase. Majoritatea pacienţilor au prezentat creşteri considerabile ale vitaminei D serice, cât şi creşterea densităţii minerale osoase la nivelul coloanei vertebrale lombare şi şoldului. Rezultatele au arătat efectul benefi c al suplimentării cu vitamina D şi calciu la pacienţii cu artrită reumatoidă.

Молниеносная печеночная недостаточность медикаментозного, токсиколлергического генеза, разрешенная пересадкой печени. Kлинический случай

USMF Nicolae Testemițanu, Spitalul Clinic Republican, Conferința naţională de gastroenterologie şi hepatologie cu participare internaţională ”Actualităţi în gastroenterologie şi hepatologie” 16 iunie 2016 Chișinău, Republica MoldovaAcute hepatic failure is a result of toxic effects of used medication, viral hepatic infections, autoimmune hepatitis, but also there are unknown underlining causes. Hereby we present a case of violent acute, toxic- allergic, drug induced (sulfasalazin, metilprednisolon) hepatic failure, addressed by liver transplantation.Наиболее распространенные причины молниеносной печеночной недостаточности являются токсические эффекты препаратов, вирусный гепатит, аутоиммунный гепатит, а также неизвестные или неопределенные причины. Мы представляем клинический случай молниеносной печеночной недостаточности токсикоаллергического, медикаментозного (сульфасалазин, метилпреднизолон) генеза, которая была решена путем трансплантации печени