7 research outputs found
Automatic and Efficient Fall Risk Assessment Based on Machine Learning
Automating fall risk assessment, in an efficient, non-invasive manner, specifically in the elderly population, serves as an efficient means for implementing wide screening of individuals for fall risk and determining their need for participation in fall prevention programs. We present an automated and efficient system for fall risk assessment based on a multi-depth camera human motion tracking system, which captures patients performing the well-known and validated Berg Balance Scale (BBS). Trained machine learning classifiers predict the patient’s 14 scores of the BBS by extracting spatio-temporal features from the captured human motion records. Additionally, we used machine learning tools to develop fall risk predictors that enable reducing the number of BBS tasks required to assess fall risk, from 14 to 4–6 tasks, without compromising the quality and accuracy of the BBS assessment. The reduced battery, termed Efficient-BBS (E-BBS), can be performed by physiotherapists in a traditional setting or deployed using our automated system, allowing an efficient and effective BBS evaluation. We report on a pilot study, run in a major hospital, including accuracy and statistical evaluations. We show the accuracy and confidence levels of the E-BBS, as well as the average number of BBS tasks required to reach the accuracy thresholds. The trained E-BBS system was shown to reduce the number of tasks in the BBS test by approximately 50% while maintaining 97% accuracy. The presented approach enables a wide screening of individuals for fall risk in a manner that does not require significant time or resources from the medical community. Furthermore, the technology and machine learning algorithms can be implemented on other batteries of medical tests and evaluations
Spatio-Temporal Calibration of Multiple Kinect Cameras Using 3D Human Pose
RGB and depth cameras are extensively used for the 3D tracking of human pose and motion. Typically, these cameras calculate a set of 3D points representing the human body as a skeletal structure. The tracking capabilities of a single camera are often affected by noise and inaccuracies due to occluded body parts. Multiple-camera setups offer a solution to maximize coverage of the captured human body and to minimize occlusions. According to best practices, fusing information across multiple cameras typically requires spatio-temporal calibration. First, the cameras must synchronize their internal clocks. This is typically performed by physically connecting the cameras to each other using an external device or cable. Second, the pose of each camera relative to the other cameras must be calculated (Extrinsic Calibration). The state-of-the-art methods use specialized calibration session and devices such as a checkerboard to perform calibration. In this paper, we introduce an approach to the spatio-temporal calibration of multiple cameras which is designed to run on-the-fly without specialized devices or equipment requiring only the motion of the human body in the scene. As an example, the system is implemented and evaluated using Microsoft Azure Kinect. The study shows that the accuracy and robustness of this approach is on par with the state-of-the-art practices
3D motion capture system for assessing patient motion during FuglâMeyer stroke rehabilitation testing
The authors introduce a novel markerâless multiâcamera setup that allows easy synchronisation between 3D cameras as well as a novel pose estimation method that is calculated on the fly based on the human body being tracked, and thus requires no calibration session nor special calibration equipment. They show high accuracy in both calibration and data merging and is on par with equipmentâbased calibration. They deduce several insights and practical guidelines for the camera setup and for the preferred data merging methods. Finally, they present a test case that computerises the FuglâMeyer stroke rehabilitation protocol using the authorsâ multiâsensor capture system. They conducted a Helsinkiâapproved research in a hospital in which they collected data on stroke patients and healthy subjects using their multiâcamera system. Spatioâtemporal features were extracted from the acquired data and machine learningâbased evaluations were applied. Results showed that patients and healthy subjects can be correctly classified at a rate of above 90%. Furthermore, they show that the most significant features in the classification are strongly correlated with the FuglâMeyer guidelines. This demonstrates the feasibility of a lowâcost, flexible and nonâinvasive motion capture system that can potentially be operated in a home setting
Automatic and Efficient Fall Risk Assessment Based on Machine Learning
Automating fall risk assessment, in an efficient, non-invasive manner, specifically in the elderly population, serves as an efficient means for implementing wide screening of individuals for fall risk and determining their need for participation in fall prevention programs. We present an automated and efficient system for fall risk assessment based on a multi-depth camera human motion tracking system, which captures patients performing the well-known and validated Berg Balance Scale (BBS). Trained machine learning classifiers predict the patientâs 14 scores of the BBS by extracting spatio-temporal features from the captured human motion records. Additionally, we used machine learning tools to develop fall risk predictors that enable reducing the number of BBS tasks required to assess fall risk, from 14 to 4â6 tasks, without compromising the quality and accuracy of the BBS assessment. The reduced battery, termed Efficient-BBS (E-BBS), can be performed by physiotherapists in a traditional setting or deployed using our automated system, allowing an efficient and effective BBS evaluation. We report on a pilot study, run in a major hospital, including accuracy and statistical evaluations. We show the accuracy and confidence levels of the E-BBS, as well as the average number of BBS tasks required to reach the accuracy thresholds. The trained E-BBS system was shown to reduce the number of tasks in the BBS test by approximately 50% while maintaining 97% accuracy. The presented approach enables a wide screening of individuals for fall risk in a manner that does not require significant time or resources from the medical community. Furthermore, the technology and machine learning algorithms can be implemented on other batteries of medical tests and evaluations
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Single-cell epigenomics reveals mechanisms of human cortical development.
During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape1. In the developing brain, cell fate specification and topographic identity are important for defining cell identity2 and confer selective vulnerabilities to neurodevelopmental disorders3. Here, to identify cell-type-specific chromatin accessibility patterns in the developing human brain, we used a single-cell assay for transposase accessibility by sequencing (scATAC-seq) in primary tissue samples from the human forebrain. We applied unbiased analyses to identify genomic loci that undergo extensive cell-type- and brain-region-specific changes in accessibility during neurogenesis, and an integrative analysis to predict cell-type-specific candidate regulatory elements. We found that cerebral organoids recapitulate most putative cell-type-specific enhancer accessibility patterns but lack many cell-type-specific open chromatin regions that are found in vivo. Systematic comparison of chromatin accessibility across brain regions revealed unexpected diversity among neural progenitor cells in the cerebral cortex and implicated retinoic acid signalling in the specification of neuronal lineage identity in the prefrontal cortex. Together, our results reveal the important contribution of chromatin state to the emerging patterns of cell type diversity and cell fate specification and provide a blueprint for evaluating the fidelity and robustness of cerebral organoids as a model for cortical development
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TAD evolutionary and functional characterization reveals diversity in mammalian TAD boundary properties and function.
Topological associating domains (TADs) are self-interacting genomic units crucial for shaping gene regulation patterns. Despite their importance, the extent of their evolutionary conservation and its functional implications remain largely unknown. In this study, we generate Hi-C and ChIP-seq data and compare TAD organization across four primate and four rodent species and characterize the genetic and epigenetic properties of TAD boundaries in correspondence to their evolutionary conservation. We find 14% of all human TAD boundaries to be shared among all eight species (ultraconserved), while 15% are human-specific. Ultraconserved TAD boundaries have stronger insulation strength, CTCF binding, and enrichment of older retrotransposons compared to species-specific boundaries. CRISPR-Cas9 knockouts of an ultraconserved boundary in a mouse model lead to tissue-specific gene expression changes and morphological phenotypes. Deletion of a human-specific boundary near the autism-related AUTS2 gene results in the upregulation of this gene in neurons. Overall, our study provides pertinent TAD boundary evolutionary conservation annotations and showcases the functional importance of TAD evolution