Development of chronic pulmonary aspergillosis in a patient with NTM-LD.

<p>Chest computed tomography images are shown for a 69-year-old female patient with <i>Mycobacterium intracellulare</i> lung disease. (A) At the time of initiation of antibiotic therapy for <i>M</i>. <i>intracellulare</i> lung disease, there was a large cavitary consolidation in the right upper lobe. Serum <i>Aspergillus</i> precipitin antibody was negative. (B) After 12 months of antibiotic therapy for <i>M</i>. <i>intracellulare</i> lung disease, cavitary consolidation in the right upper lobe was improved, and sputum cultures for NTM were negative. (C) After 18 months of antibiotic therapy for <i>M</i>. <i>intracellulare</i> lung disease, the patient’s respiratory symptoms and the consolidation in the right upper lobe were aggravated. Sputum cultures for NTM were negative. However, serum <i>Aspergillus</i> precipitin antibody was strongly positive, and chronic pulmonary aspergillosis was diagnosed.</p

Cumulative percentage of patients who developed chronic pulmonary aspergillosis after initiating treatment for NTM-LD.

<p>Cumulative percentage of patients who developed chronic pulmonary aspergillosis after initiating treatment for NTM-LD.</p

Univariate and multivariable analyses of risk factors for development of CPA.

<p>Univariate and multivariable analyses of risk factors for development of CPA.</p

Survival curves in study patient groups using Kaplan-Meier analysis.

<p>Survival curves in study patient groups using Kaplan-Meier analysis.</p