84 research outputs found
A4 Flavor Models in Split Seesaw Mechanism
A seesaw mechanism in an extra-dimension, known as the split seesaw
mechanism, provides a natural way to realize a splitting mass spectrum of
right-handed neutrinos. It leads to one keV sterile neutrino as a dark matter
candidate and two heavy right-handed neutrinos being responsible for
leptogenesis to explain the observed baryon asymmetry of the Universe. We study
models based on flavor symmetry in the context of the split seesaw
mechanism. It is pointed out that most of known flavor models with three
right-handed neutrinos being triplet suffer from a degeneracy problem for
the bulk mass terms, which disturbs the split mechanism for right-handed
neutrino mass spectrum. Then we construct a new flavor model to work in
the split seesaw mechanism. In the model, the experimentally observed neutrino
masses and mixing angles can be realized from both type I+II seesaw
contributions. The model predicts the symmetry in the neutrino mass
matrix at the leading order, resulting in the vanishing and
maximal . The flavor symmetry is broken via the flavon
vacuum alignment which can be obtained from the orbifold compactification. The
model can be consistent with all data of neutrino oscillation experiments,
cosmological discussions of dark matter abundance, leptogenesis, and recent
astrophysical data.Comment: 21 pages, 1 figure, version to appear in JHE
Reconstruction of Fingertip Amputations by Partial Composite Toe Transfer with Short Vascular Pedicle
Complement System in the Pathogenesis of Benign Lymphoepithelial Lesions of the Lacrimal Gland
Analysis of anti-C1q autoantibodies by western blot
Anti-C1q autoantibodies may be found in many conditions, most commonly in systemic lupus erythematosus (SLE) and hypocomplementemic urticarial vasculitis syndrome (HUVS), and are diagnostic markers as well as disease activity markers in lupus nephritis. Sera from patients with SLE and HUVS show partly distinct autoantibody reactivities to separated protein chains B and C of the first component of complement, C1q. These different binding specificities can be detected by Western blot analysis of the autoantibodies under reducing conditions. Results may help clinicians to differentiate between SLE and HUVS
Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy
Dislocation after total hip replacement – there is no such thing as a safe zone for socket placement with the posterior approach
Malorientation of the socket contributes to instability after hip arthroplasty but the optimal orientation of the cup in relation to the pelvis has not been unequivocally described. Large radiological studies are few and problems occur with film standardisation, measurement methodology used and alternative definitions of describing acetabular orientation. A cohort of 1,578 patients from a single institution is studied where all patient data was collected prospectively. Risk factors for patients undergoing surgery are analysed. Radiological data was compared between a series of non-dislocating hips and dislocating cases matched 2:1 by operation type, age and diagnosis.??
Femoral cement within cement technique in carefully selected aseptic revision arthroplasties
The aim of this study was to evaluate the clinical and radiological results in a group of patients who underwent aseptic revision hip arthroplasty using the cement within cement (CWC) technique. Between 1999 and 2005, 37 aseptic revision hip operations were performed. There were 30 women and five men, with an average age of 68 years. The reasons for revision were femoral stem fracture, cup failure, acetabular protrusion after hemi-arthroplasty and recurrent dislocation. At an average follow-up of 46 months, none of the patients required further femoral revision. The average post-operative Merle D’Aubigne score was 16.6 points (p<0.05). No evidence of radiological stem failure was observed and no femoral component was considered to be at risk for loosening. In this series of patients, the CWC technique provided consistent with high functional outcomes. This valid and effective alternative should be considered in carefully selected aseptic cases
- …