24 research outputs found
Pecuniary Knowledge Externalities and Innovation: Intersectoral Linkages and Their Effects Beyond Technological Spillovers
A Guide to Medications Inducing Salivary Gland Dysfunction, Xerostomia, and Subjective Sialorrhea: A Systematic Review Sponsored by the World Workshop on Oral Medicine VI
Tratamento farmacolĂłgico do transtorno de ansiedade generalizada: perspectivas futuras Pharmacological treatment of generalized anxiety disorder: future perspectives
O presente artigo apresenta uma visĂŁo atualizada e ampla do tratamento farmacolĂłgico do transtorno de ansiedade generalizada (TAG). SĂŁo revistos os medicamentos com eficácia comprovada em estudos controlados e atualmente disponĂveis na clĂnica (benzodiazepĂnicos, buspirona, antidepressivos, betabloqueadores, antipsicĂłticos e extrato de kava-kava). A seguir, baseados nesses dados, propõe-se um algoritmo de tratamento do TAG. SĂŁo apresentadas as principais linhas de pesquisa de novos fármacos ansiolĂticos, descrevendo os principais achados clĂnicos e prĂ©-clĂnicos.<br>This article presents an updated and broad perspective of the pharmacological treatment of generalized anxiety disorder (GAD). Medications proven to be efficacious in controlled studies and available in the clinic setting were reviewed (benzodiazepines, buspirone, antidepressives, beta-blocking agents, antipsychotics and kava-kava extract). From this data, an algorithm for GAD treatment is proposed. In addition, the main research lines on new anxiolytic drugs and their stage of clinical or pre-clinical development are presented