Aerosol-type classification based on AERONET version 3 inversion products

© Author(s) 2019. This work is distributed under the Creative Commons Attribution 4.0 License.This study proposes an aerosol-type classification based on the particle linear depolarization ratio (PLDR) and single-scattering albedo (SSA) provided in the AErosol RObotic NETwork (AERONET) version 3 level 2.0 inversion product. We compare our aerosol-type classification with an earlier method that uses fine-mode fraction (FMF) and SSA. Our new method allows for a refined classification of mineral dust that occurs as a mixture with other absorbing aerosols: pure dust (PD), dust-dominated mixed plume (DDM), and pollutant-dominated mixed plume (PDM). We test the aerosol classification at AERONET sites in East Asia that are frequently affected by mixtures of Asian dust and biomass-burning smoke or anthropogenic pollution. We find that East Asia is strongly affected by pollution particles with high occurrence frequencies of 50 % to 67 %. The distribution and types of pollution particles vary with location and season. The frequency of PD and dusty aerosol mixture (DDM+PDM) is slightly lower (34 % to 49 %) than pollution-dominated mixtures. Pure dust particles have been detected in only 1 % of observations. This suggests that East Asian dust plumes generally exist in a mixture with pollution aerosols rather than in pure form. In this study, we have also considered data from selected AERONET sites that are representative of anthropogenic pollution, biomass-burning smoke, and mineral dust. We find that average aerosol properties obtained for aerosol types in our PLDR–SSA-based classification agree reasonably well with those obtained at AERONET sites representative for different aerosol types.Peer reviewe

AG490 and PF431396 Sensitive Tyrosine Kinase Control the Population Heterogeneity of Basal STAT1 Activity in Ube1l Deficient Cells

A population often contains distinct sub-populations, thereby increasing the complexity of the overall heterogeneity. However, the cellular origin and biological relevance of sub-populations in cell population have not been clearly identified. Here we demonstrated the novel roles of ISGylation, which is an IFN-induced post-translational modification, controlling heterogeneity at the population level in cultured adherent cells. Without UBE1L, an E1 enzyme of ISGylation, mouse embryonic fibroblasts (MEF) exhibited low viral resistance despite high STAT1 and ISG expression compared with the wild-type MEF. We observe that Ube1l(-/-) MEF populations consist of two behaviorally distinguishable sub-populations with distinct basal STAT1 activity, while wild-type MEF populations are unimodal. This population heterogeneity in Ube1l knock-out cells was perturbed by tyrosine kinase inhibitors, AG490 and PF431396. In contrast, the neutralization of type I IFN did not affect population heterogeneity. Based on these results, we concluded that UBE1L functions to adjust basal immunological states with the regulation of population heterogeneity.111Ysciescopu

Improved prediction of shell side heat transfer in horizontal evaporative shell and tube heat exchangers

This paper presents an improved prediction method for the heat transfer and pressure drop in the shell side of a horizontal shell and tube evaporator. The results from an experimental test program are used in which a wide range of evaporating two-phase shell side flow data was collected from a TEMA E-shell evaporator. The data are compared with shell side heat transfer coefficient and pressure drop models for homogeneous and stratified flow. The comparison suggests a deterioration in the heat transfer data at low mass fluxes consistent with a transition from homogeneous to stratified flow. The pressure drop data suggest a stratified flow across the full test range. A new model is presented that suggests the transition in the heat transfer data may be due to the extent of tube wetting in the upper tube bundle. The new model, which also takes into account the orientation of the shell side baffles, provides a vast improvement on the predictions of a homogenous type model. The new model would enable designers of shell side evaporators/reboilers to avoid operating conditions where poor heat transfer could be expected, and it would also enable changes in process conditions to be assessed for their implications on likely heat transfer performance. (Abstract from WOK

Support for the Rightscon Toronto 2018 conference

The report documents key advances, significant research findings, important outcomes, and innovative outputs of the conference. RightsCon is the leading global summit on human rights in the digital age. By bringing together a diverse community of world leading experts, a wide-ranging program addressed key issues at the intersection of human rights, technology, and society. Thousands of the world’s leading experts convened to participate in, and advance conversations around these issues. Twelve hundred participants (from Azerbaijan, Brazil, Cameroon, Egypt, Gambia, Honduras, India, Kenya, Malaysia, Nigeria, Pakistan, Syria, Thailand, Uganda, Venezuela, Zimbabwe, and other Global South countries) received complimentary tickets

Ubiquitin-like modifier FAT10 attenuates RIG-I mediated antiviral signaling by segregating activated RIG-I from its signaling platform

RIG-I is a key cytosolic RNA sensor that mediates innate immune defense against RNA virus. Aberrant RIG-I activity leads to severe pathological states such as autosomal dominant multi-system disorder, inflammatory myophathies and dermatomyositis. Therefore, identification of regulators that ensure efficient defense without harmful immune-pathology is particularly critical to deal with RIG-I-associated diseases. Here, we presented the inflammatory inducible FAT10 as a novel negative regulator of RIG-Imediated inflammatory response. In various cell lines, FAT10 protein is undetectable unless it is induced by pro-inflammatory cytokines. FAT10 non-covalently associated with the 2CARD domain of RIG-I, and inhibited viral RNA-induced IRF3 and NF-kappa B activation through modulating the RIG-I protein solubility. We further demonstrated that FAT10 was recruited to RIG-I-TRIM25 to form an inhibitory complex where FAT10 was stabilized by E3 ligase TRIM25. As the result, FAT10 inhibited the antiviral stress granules formation contains RIG-I and sequestered the active RIG-I away from the mitochondria. Our study presented a novel mechanism to dampen RIG-I activity. Highly accumulated FAT10 is observed in various cancers with pro-inflammatory environment, therefore, our finding which uncovered the suppressive effect of the accumulated FAT10 during virus-mediated inflammatory response may also provide molecular clue to understand the carcinogenesis related with infection and inflammation.11109Ysciescopu

Flyer: 51st Anniversary of Women\u27s Suffrage

Feminist are all around you Handout for the 51st Anniversary of Women\u27s Suffrage, August 26, 1971. Discusses the widening gap between women and men, and books available at public libraries

Pamphlet: A Brief Guide to Politics \u2792

Pamphlet issued by Americans for Peace Now, an American Jewish membership organization and support group for Israel’s largest peace group - Shalom Achshav. The brochure urges candidates to consider their positions on U.S. policy toward Israel and the Middle East. Date: 1992 Box 23 Folder 1

Youth Program Targets Crime

A NEON proposal will become reality this summer for 100 youth ages 10 to 15. A demonstration program called Summer of Safety will guide youth to use crime prevention strategies and to undertake projects to increase safety in their neighborhoods. NEON\u27s innovative proposal won highly competitive funding by the Corporation for National Service, an initiative of the Clinton Administration. The activities will take place at South Norwalk community Center, Roodner Court Neighborhood Center, and G. W. Carver Foundation from June 21 through August 20, 1994