A cultura do urucum em 1994.

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How latanoprost changed glaucoma management

Glaucoma is currently considered one of the leading causes of severe visual impairment and blindness worldwide. Topical medical therapy represents the treatment of choice for many glaucoma patients. Introduction of latanoprost, 25 years ago, with an entirely new mechanism of action from that of the antiglaucoma drugs used up to that time was a very important milestone. Since then, due mainly to their efficacy, limited systemic side effects and once daily dosing, prostaglandin analogues (PGAs) have become as the first-choice treatment for primary open-angle glaucoma. PGAs are in general terms well tolerated, although they are associated with several mild to moderate ocular and periocular adverse events. Among them, conjunctival hyperemia, eyelash changes, eyelid pigmentation, iris pigmentation and hypertrichosis around the eyes are the most prevalent. The objective of this paper is to review the role of PGAs in the treatment of glaucoma over the 25 years since the launch of Latanoprost and their impact on clinical practice outcomes

Microstructure identification via detrended fluctuation analysis of ultrasound signals

We describe an algorithm for simulating ultrasound propagation in random one-dimensional media, mimicking different microstructures by choosing physical properties such as domain sizes and mass densities from probability distributions. By combining a detrended fluctuation analysis (DFA) of the simulated ultrasound signals with tools from the pattern-recognition literature, we build a Gaussian classifier which is able to associate each ultrasound signal with its corresponding microstructure with a very high success rate. Furthermore, we also show that DFA data can be used to train a multilayer perceptron which estimates numerical values of physical properties associated with distinct microstructures.Comment: Submitted to Phys. Rev.

Sobrevivência de Pseudomonas solanacearum Raça 2 em solos de terra-firme do Estado do Amazonas.

Made available in DSpace on 2019-11-07T18:08:42Z (GMT). No. of bitstreams: 1 FitoBRa42273.pdf: 4499760 bytes, checksum: 87c4aedf5136f6c0442944a667ff0f1e (MD5) Previous issue date: 1993bitstream/item/195692/1/FitoBRa-422-73.pd

BRS - Prata Caprichosa.

BRS - Prata Caprichosa: cultivar de bananeira resistente à sigatoka-negra. Características fitotécnicas da BRS - Prata Caprichosa. Reação da BRS - Prata Caprichosa a doenças e pragas.bitstream/item/126443/1/Folder-Prata-Caprichosa.pd

Avaliação de custos de produção em sistemas de policultivos.

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MicroShunt versus trabeculectomy for surgical management of glaucoma: a retrospective analysis

This case-control study aims to compare the efficacy, safety, and postoperative burden of MicroShunt versus trabeculectomy. The first consecutive cohort of MicroShunt procedures (n = 101) was matched to recent historical trabeculectomy procedures (n = 101) at two London hospital trusts. Primary endpoints included changes in intraocular pressure (IOP) and glaucoma medications. Secondary outcome measures included changes in retinal nerve fibre layer (RNFL) thickness, rates of complications, further theatre interventions, and the number of postoperative visits. From the baseline to Month-18, the median [interquartile range] IOP decreased from 22 [17–29] mmHg (on 4 [3–4] medications) to 15 [10–17] mmHg (on 0 [0–2] medications) and from 20 [16–28] mmHg (on 4 [3–4] medications) to 11 [10–13] mmHg (on 0 [0–0] medications) in the MicroShunt and trabeculectomy groups, respectively. IOP from Month-3 was significantly higher in the MicroShunt group (p = 0.006), with an increased number of medications from Month-12 (p = 0.024). There were greater RNFL thicknesses from Month-6 in the MicroShunt group (p = 0.005). The rates of complications were similar (p = 0.060) but with fewer interventions (p = 0.031) and postoperative visits (p = 0.001) in the MicroShunt group. Therefore, MicroShunt has inferior efficacy to trabeculectomy in lowering IOP and medications but provides a better safety profile and postoperative burden and may delay RNFL loss

Age-related retinal thickness in Down's syndrome: A high-risk population for dementia.

Introduction:People with Down's syndrome (DS) have a high prevalence of early-onset Alzheimer's disease. Early markers of Alzheimer's disease pathology identifiable before clinical change are needed for the evaluation of preventative treatments. The retina, an extension of the brain, may provide a noninvasive imaging site. Methods:Forty-nine adults with DS and 36 age-matched controls completed retinal nerve fibre layer (RNFL) assessments using optical coherence tomography. RNFL thickness was analyzed in relation to cognitive status and age and previously acquired cortical thickness and cerebral amyloid β binding data in a subgroup. Results:RNFL thickness was greater in the DS group and did not show age-related thinning. RNFL correlated positively with cognitive scores and cortical thickness and was reduced in participants with positive cerebral amyloid β binding. Discussion:Increased RNFL in adults with DS may represent early Alzheimer's disease-related changes. Thinning was present in those with cerebral amyloid β binding, independent of age

Comportamento do urucuzeiro (Bixa orellana) em sistema de policultivo, submetido a dois níveis de adubação e inoculação ou não das plantas com FMVA: produção.

Com a finalidade de recuperar uma área abandonada de um seringal pertencente ao CPAA/Embrapa, instalou-se um experimento com sistemas de cultivo, onde o urucuzeiro foi instalado no sistema composto por cupuaçu, pupunha e castanha-do-brasil.bitstream/item/180876/1/Recuperacao-126-131.pd

Inseticidas recomendados, limites de resíduos e indicações técnicas para aplicação no controle de pragas durante o armazenamento de grãos de milho.

Esta publicação tem como objetivo orientar técnicos, produtores, extensionistas, operadores agroindustriais e demais agentes das cadeias produtivas quanto aos inseticidas registrados para controle de insetos-praga que atacam os grãos de milho durante o armazenamento, sobre os LMR permitidos e as recomendações para aplicação de inseticidas. Estas orientações poderão auxiliar os produtores no armazenamento dos grãos de milho com mais qualidade, reduzindo as perdas e evitando a contaminação dos grãos por resíduos acima dos LMR permitidos nos mercados nacional e internacional. O trabalho contribui para o atendimento do ODS 12: ?Assegurar padrões de produção e de consumo sustentáveis?, e mais especificamente o tópico 12.3: ?Até 2030, reduzir pela metade o desperdício de alimentos per capita mundial, nos níveis de varejo e do consumidor, e reduzir as perdas de alimentos ao longo das cadeias de produção e abastecimento, incluindo as perdas pós-colheita?, por apresentar indicações sobre o uso de inseticidas na etapa pós-colheita, cujo principal objetivo é reduzir as perdas decorrentes da infestação por insetos-pragas que causam danos aos grãos de milho. As recomendações descritas poderão auxiliar os produtores e operadores de armazéns a reduzirem as perdas por insetos-pragas e, mesmo utilizando o controle químico, atingir maior sustentabilidade pela adoção de práticas adequadas na aplicação dos inseticidas que atinjam o alvo com eficiência e produzam resíduos que persistam nos grãos dentro dos níveis aceitáveis nacional e internacionalmente. Dessa forma, a publicação poderá contribuir para atingir a meta de reduzir as perdas de alimentos, especialmente grãos de milho, na etapa pós-colheita.bitstream/item/217756/1/Circ-Tec.267.pd