1,180 research outputs found
Adverse drug reaction reporting by community pharmacists- The barriers and facilitators
Purpose:
The United Kingdom's âYellow Card Schemeâ for reporting of adverse drug reactions (ADRs) has been operating for 50 years, but reporting rates by community pharmacists remain low. The aim of the study was therefore to investigate the views and experiences of ADR reporting by community pharmacists in Wales, with a particular focus on the potential barriers and facilitators to reporting.
Methods:
Following ethics approval and piloting, a selfâcomplete questionnaire was mailed to all registered community pharmacies in Wales, UK (n = 713). A followâup mailing was sent to nonresponders after 2 weeks.
Results
A response rate of 52% (n = 372) was achieved, of whom 57% had never submitted a yellow card. Key barriers to reporting were not seeing ADRs, difficulty identifying the causative drug, not being sure which ADRs to report, and lack of time. Key facilitators were being able to report through dispensary software and having clearer guidelines about what to report. Differences between those who had previously reported ADRs and those who had not suggested lack of confidence and uncertainty about what to report were more of a barrier for nonreporters. Conversely, reporters wanted feedback on reports, ability to keep reports on their dispensary records, and remuneration to aid them with reporting.
Conclusions
While the respondents generally expressed positive attitudes towards ADR reporting, a number of barriers and potential facilitators were nevertheless identified. Clearer support and guidance for reporting, such as through a âchampionsâ scheme similar to that run in Welsh hospitals, may help current nonreporters to engage
Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the natural product prodigiosin, a tripyrrolic molecule produced by microorganisms such as Streptomyces and Serratia, facilitates chloride/bicarbonate exchange (antiport) across liposomal membranes. Higher concentrations of simple synthetic molecules based on a 4,6-dihydroxyisophthalamide core are also shown to facilitate this antiport process. Although it is well known that proteins regulate Cl-/HCO3- exchange in cells, these results suggest that small molecules may also be able to regulate the concentration of these anions in biological systems
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women.
Disorder Effects on Exciton-Polariton Condensates
The impact of a random disorder potential on the dynamical properties of Bose
Einstein condensates is a very wide research field. In microcavities, these
studies are even more crucial than in the condensates of cold atoms, since
random disorder is naturally present in the semiconductor structures. In this
chapter, we consider a stable condensate, defined by a chemical potential,
propagating in a random disorder potential, like a liquid flowing through a
capillary. We analyze the interplay between the kinetic energy, the
localization energy, and the interaction between particles in 1D and 2D
polariton condensates. The finite life time of polaritons is taken into account
as well. In the first part, we remind the results of [G. Malpuech et al. Phys.
Rev. Lett. 98, 206402 (2007).] where we considered the case of a static
condensate. In that case, the condensate forms either a glassy insulating phase
at low polariton density (strong localization), or a superfluid phase above the
percolation threshold. We also show the calculation of the first order spatial
coherence of the condensate versus the condensate density. In the second part,
we consider the case of a propagating non-interacting condensate which is
always localized because of Anderson localization. The localization length is
calculated in the Born approximation. The impact of the finite polariton life
time is taken into account as well. In the last section we consider the case of
a propagating interacting condensate where the three regimes of strong
localization, Anderson localization, and superfluid behavior are accessible.
The localization length is calculated versus the system parameters. The
localization length is strongly modified with respect to the non-interacting
case. It is infinite in the superfluid regime whereas it is strongly reduced if
the fluid flows with a supersonic velocity.Comment: chapter for a book "Exciton Polaritons in Microcavities: New
Frontiers" by Springer (2012), the original publication is available at
http://www.springerlink.co
Beyond Gross-Pitaevskii Mean Field Theory
A large number of effects related to the phenomenon of Bose-Einstein
Condensation (BEC) can be understood in terms of lowest order mean field
theory, whereby the entire system is assumed to be condensed, with thermal and
quantum fluctuations completely ignored. Such a treatment leads to the
Gross-Pitaevskii Equation (GPE) used extensively throughout this book. Although
this theory works remarkably well for a broad range of experimental parameters,
a more complete treatment is required for understanding various experiments,
including experiments with solitons and vortices. Such treatments should
include the dynamical coupling of the condensate to the thermal cloud, the
effect of dimensionality, the role of quantum fluctuations, and should also
describe the critical regime, including the process of condensate formation.
The aim of this Chapter is to give a brief but insightful overview of various
recent theories, which extend beyond the GPE. To keep the discussion brief,
only the main notions and conclusions will be presented. This Chapter
generalizes the presentation of Chapter 1, by explicitly maintaining
fluctuations around the condensate order parameter. While the theoretical
arguments outlined here are generic, the emphasis is on approaches suitable for
describing single weakly-interacting atomic Bose gases in harmonic traps.
Interesting effects arising when condensates are trapped in double-well
potentials and optical lattices, as well as the cases of spinor condensates,
and atomic-molecular coupling, along with the modified or alternative theories
needed to describe them, will not be covered here.Comment: Review Article (19 Pages) - To appear in 'Emergent Nonlinear
Phenomena in Bose-Einstein Condensates: Theory and Experiment', Edited by
P.G. Kevrekidis, D.J. Frantzeskakis and R. Carretero-Gonzalez (Springer
Verlag
Coherent spinor dynamics in a spin-1 Bose condensate
Collisions in a thermal gas are perceived as random or incoherent as a
consequence of the large numbers of initial and final quantum states accessible
to the system. In a quantum gas, e.g. a Bose-Einstein condensate or a
degenerate Fermi gas, the phase space accessible to low energy collisions is so
restricted that collisions be-come coherent and reversible. Here, we report the
observation of coherent spin-changing collisions in a gas of spin-1 bosons.
Starting with condensates occupying two spin states, a condensate in the third
spin state is coherently and reversibly created by atomic collisions. The
observed dynamics are analogous to Josephson oscillations in weakly connected
superconductors and represent a type of matter-wave four-wave mixing. The
spin-dependent scattering length is determined from these oscillations to be
-1.45(18) Bohr. Finally, we demonstrate coherent control of the evolution of
the system by applying differential phase shifts to the spin states using
magnetic fields.Comment: 19 pages, 3 figure
Cross-species microsatellite amplification in South American Caimans (Caiman spp and Paleosuchus palpebrosus)
Seagrass can mitigate negative ocean acidification effects on calcifying algae
The ultimate effect that ocean acidification (OA) and warming will have on the physiology of calcifying algae is still largely uncertain. Responses depend on the complex interactions between seawater chemistry, global/local stressors and species-specific physiologies. There is a significant gap regarding the effect that metabolic interactions between coexisting species may have on local seawater chemistry and the concurrent effect of OA. Here, we manipulated CO2 and temperature to evaluate the physiological responses of two common photoautotrophs from shallow tropical marine coastal ecosystems in Brazil: the calcifying alga Halimeda cuneata, and the seagrass Halodule wrightii. We tested whether or not seagrass presence can influence the calcification rate of a widespread and abundant species of Halimeda under OA and warming. Our results demonstrate that under elevated CO2, the high photosynthetic rates of H. wrightii contribute to raise H. cuneata calcification more than two-fold and thus we suggest that H. cuneata populations coexisting with H. wrightii may have a higher resilience to OA conditions. This conclusion supports the more general hypothesis that, in coastal and shallow reef environments, the metabolic interactions between calcifying and non-calcifying organisms are instrumental in providing refuge against OA effects and increasing the resilience of the more OA-susceptible species.E.B. would like to thank the Coordenação de Aperfeiçoamento de Pessoas de NĂvel Superior (CAPES) for Masters
funding. Funding for this project came from the Synergism grant (CNPq 407365/2013-3). We extend our thanks
to the Brazil-based Projeto Coral Vivo and its sponsor PetroBras Ambiental for providing the Marine Mesocosm
structure and experimental assistance.info:eu-repo/semantics/publishedVersio
Treatment outcomes of new tuberculosis patients hospitalized in Kampala, Uganda: a prospective cohort study.
BACKGROUND: In most resource limited settings, new tuberculosis (TB) patients are usually treated as outpatients. We sought to investigate the reasons for hospitalisation and the predictors of poor treatment outcomes and mortality in a cohort of hospitalized new TB patients in Kampala, Uganda. METHODS AND FINDINGS: Ninety-six new TB patients hospitalised between 2003 and 2006 were enrolled and followed for two years. Thirty two were HIV-uninfected and 64 were HIV-infected. Among the HIV-uninfected, the commonest reasons for hospitalization were low Karnofsky score (47%) and need for diagnostic evaluation (25%). HIV-infected patients were commonly hospitalized due to low Karnofsky score (72%), concurrent illness (16%) and diagnostic evaluation (14%). Eleven HIV uninfected patients died (mortality rate 19.7 per 100 person-years) while 41 deaths occurred among the HIV-infected patients (mortality rate 46.9 per 100 person years). In all patients an unsuccessful treatment outcome (treatment failure, death during the treatment period or an unknown outcome) was associated with duration of TB symptoms, with the odds of an unsuccessful outcome decreasing with increasing duration. Among HIV-infected patients, an unsuccessful treatment outcome was also associated with male sex (P = 0.004) and age (P = 0.034). Low Karnofsky score (aHR = 8.93, 95% CI 1.88 - 42.40, P = 0.001) was the only factor significantly associated with mortality among the HIV-uninfected. Mortality among the HIV-infected was associated with the composite variable of CD4 and ART use, with patients with baseline CD4 below 200 cells/”L who were not on ART at a greater risk of death than those who were on ART, and low Karnofsky score (aHR = 2.02, 95% CI 1.02 - 4.01, P = 0.045). CONCLUSION: Poor health status is a common cause of hospitalisation for new TB patients. Mortality in this study was very high and associated with advanced HIV Disease and no use of ART
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