Synthesis and Antimicrobial Activities of Some New Pyrazoles, Oxadiazoles and Isoxazole Bearing Benzofuran Moiety

The synthesis of novel derivatives of pyrazole-3-carboxylate (3–5) from methyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate (1) is reported. Synthesis of substituted 1,3,4-oxadiazoles (7–11) and 5-amino pyrazole-4-carboxylate (12) derivatives starting fromthe 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (6) are also described. Twelve new compounds were synthesized and their identities have been established on the basis of elemental and spectroscopic analysis such as IR, 1H NMR, 13C NMR, Mass Spectra. The compounds were also screened for their antibacterial and antifungal activities against Gram-positive, Gramnegative bacteria and a fungus.KEYWORDS 2,4-Dioxobutanoate, isoxazole, pyrazoles, pyrazole-3-carbohydrazide, 1,3,4-oxadiazoles