8 research outputs found
The potential of legume pods as supplements to low quality roughages
- Publication venue
- 'African Journals Online (AJOL)'
- Publication date
- 01/01/2000
- Field of study
(South African J of Animal Science, 2000, 30, Supplement 1: 107-108
Effect of sorghum tannins in sheep fed with high-concentrate diets
- Author
- A.A.M. Oliveira
- A.L. Abdalla
- AERTS R.J.
- ATHANASIADOU S.
- BEELEN P.M.G.
- BEN SALEM H.
- BRANDT M.
- BUTLER L.G.
- BUTLER L.G.
- CABRAL L.S.
- CAMPOS F.P.
- CARRO M.D.
- DEFOOR P.J.
- GODOY P.B.
- I.C.S. Bueno
- KOMOLONG M.K.
- MAKKAR H.P.S.
- McALLAN A.B.
- McNAUGHTON S.J.
- MEAD R.
- MOULD F.L.
- NGWA A.T.
- PORTER L.J.
- PRESTON T.R.
- PĂREZ J.F.
- RAMIREZ R.G.
- REED J.D.
- S.L.S. Cabral Filho
- S.P. Gobbo
- SHERROD L.B.
- SILVA A.M.A.
- SOUZA V.G.
- SULTAN J.I.
- VALADARES R.F.D.
- VALDĂS C.
- VAN SOEST P.J.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Degradabilidade ruminal in situ de vagens de faveira (Parkia platycephala Benth.) em diferentes tamanhos de partĂculas
- Author
- A.A. Alves
- A.N. Medeiros
- A.P. Braga
- A.R. Azevedo
- AERTS R.J.
- ALVES A.A.
- ANDRADE P.
- BATISTA A.M.
- CAMPOS J.
- CARVALHO J.H.
- COSTA M.R.
- HALL M.B.
- J.N.M. Neiva
- LOYOLA V.R.
- LUKHELE M.S.
- MAKKAR H.P.S.
- MATHEW S.
- MICHALET-DOREAU B.
- MOLINA L.R.
- NASCIMENTO M.P.S.C.B.
- NGWA A.T.
- NOCEK J.E.
- NOZELLA E.F.
- R.O. Sales
- SAMPAIO I.B.M.
- SAMPAIO I.B.M.
- SNIFFEN C.J.
- TOLERA A.
- VAN SOEST P.J.
- VAN SOEST P.J.
- VIEIRA P.F.
- WEISS W.P.
- ĂRSKOV E.R.
- ĂRSKOV E.R.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Plant and Soil Metal Concentrations in Serpentine Soils and Their Influence on the Diet of Extensive Livestock Animals
- Author
- Agreil C.
- Altmann J.
- Alves S.
- Ana M. Martins
- Baumont R.
- Blanco-Penedo I.
- Brekken A.
- DoubkovĂĄ P.
- DĂez LĂĄzaro J.
- Elsa C. D. Ramalhosa
- Esther FernĂĄndez-NĂșnez
- FernĂĄndez S.
- Freitas H.
- Ghaderian S.M.
- Hostetler C.E.
- Kataeva M.N.
- Kelepertzis E.
- Kierczak J.
- Link D.D.
- LĂłpez-Alonso M.
- Maria J. Afonso
- Marina Castro
- Marta MagalhĂŁes
- Meuret M.
- Miranda M.
- Moraetis D.
- Ngwa A.T.
- Osoro K.
- Oze C.
- Pacheco F.A.L.
- Paula Plasencia
- Reeves R.D.
- Reglero M.M.
- Roggeman S.
- Shallari S.
- Shanker A.K.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
Efeitos de dietas contendo Leucaena leucocephala e Saccharomyces cerevisiae sobre a fermentação ruminal e a emissão de gås metano em bovinos
- Author
- ARAKAKI L.C.
- CABRERA E.J.I.
- CARMONA J.C.
- DEHORITY B.A.
- Eliana Aparecida Schammas
- ERWIN E.S.
- FENNER H.
- FRANZOLIN R.
- GALINDO J.
- GARCIA C.C.G.
- GIGER-REVERDIN S.
- GOERING H.K.
- JOHNSON K.A.
- João José Assumpção de Abreu Demarchi
- KNORR M.
- LANA P.R.
- LILA Z.A.
- LOURENĂO A.J.
- Magda Aparecida de Lima
- MAKKAR H.P.S
- MAKKAR H.P.S
- MANELLA Q.M.
- McGINN S.N.
- MEHREZ A.Z.
- MERTEN D.R.
- NGWA A.T.
- OLSON K.C.
- ORTOLAN J.H.
- PEDREIRA M.S.
- PEREIRA A.M.F.
- PIMENTEL GOMES F.
- PORTER L.J.
- PRIMAVESI O.
- PRIMAVESI O.
- PUCHALA R.
- Raul Franzolin
- ROA M.L.
- Rosa Toyoko Shiraishi Frighetto
- Rosana Aparecida Possenti
- VALARINI M.J.
- Van KESSEL J.A.S.
- Van SOEST P.J.
- VELOSO C.M.
- VITTI D.M.S.S.
- ĂRSKOV E.R.
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption
- Author
- Amin N. (Najaf)
- Bandinelli S.
- Barroso I.
- Bastardot F. (Francois)
- Baumeister S.E. (Sebastian)
- Beilby J. (John)
- Biffar R.
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Boyd H.A.
- Burlutsky G. (George)
- Byrne E.M.
- Caporaso N.
- Carithers T.
- Cavadino A. (Alana)
- Chan A.T.
- Chasman D.I. (Daniel)
- Cornelis M. (Marilyn)
- Couper D.J. (David)
- Cupples L.A. (Adrienne)
- Curhan G.C. (Gary)
- Dahmen N. (N.)
- Dam R.M. (Rob) van
- Danesh J. (John)
- Dedoussis G.V. (George V.)
- Deloukas P. (Panagiotis)
- Dimitriou M. (Maria)
- Duijn C.M. (Cornelia) van
- Döring A.
- Eriksson J.
- Eriksson J.G. (Johan G.)
- Esko T. (TÔnu)
- Evans M.K. (Michele)
- Feenstra B.
- Ferrucci L. (Luigi)
- Fischer K. (Krista)
- Forouhi N.G. (Nita G.)
- Franke L. (Lude)
- Franks P.W.
- Ganna A. (Andrea)
- Garcia M. (Melissa)
- Geller F. (Frank)
- Gieger C. (Christian)
- Grabe H.J. (Hans Jörgen)
- Gu F.
- Harris T.B. (Tamara)
- Heath A.C. (Andrew C.)
- Heiss G. (Gerardo)
- Ho W.-K.
- Hofman A. (Albert)
- Hottenga J.J. (Jouke Jan)
- Houston D.K.
- Hu F.B. (Frank)
- Hui J.
- Huikari V. (Ville)
- Hunter D. (David)
- Hypponen E. (Elina)
- Ikram M.A. (Arfan)
- Ingelsson E. (Erik)
- Jacobs D.R. (David)
- Jarvelin M.-R. (Marjo-Riitta)
- Jensen M.K. (Majken K.)
- Johansson I. (Ingegerd)
- Kaakinen M. (Marika)
- Kanoni S. (Stavroula)
- Karjalainen J. (Juha)
- Khaw K.T.
- Kraft P. (Peter)
- Kristal B.S.
- Kutalik Z.
- KÀhönen M. (Mika)
- Lahti J. (Jari)
- LehtimÀki T. (Terho)
- Lemaitre R.N. (Rozenn )
- Lind L. (Lars)
- Lindgren C.
- Liu Y.
- Loos R.J.F. (Ruth)
- Lorentzon M. (Mattias)
- Luan J.
- Luben R.N. (Robert)
- Magnusson P.K.E. (Patrik K. E.)
- Manichaikul A. (Ani)
- Marques-Vidal P. (Pedro)
- Martin N.G. (Nicholas)
- Mason M.A.
- Melbye M. (Mads)
- Mellström D. (Dan)
- Metspalu A. (Andres)
- Michaëlsson K.
- Mihailov E. (Evelin)
- MikkilÀ V. (Vera)
- Milani L. (Lili)
- Mitchell P. (Paul)
- Monda K.L. (Keri)
- Montgomery G.W. (Grant W.)
- Morris A.P. (Andrew)
- Mozaffarian D.
- Mukamal K. (Kenneth)
- Musani S. (Solomon)
- MĂ€gi R. (Reedik)
- MÀnnistö S. (Satu)
- Nalls M.A. (Michael)
- Nettleton J.A.
- Neuhouser M.L. (Marian L.)
- Ngwa J.S.
- Nolte I.M. (Ilja M.)
- North K.E. (Kari)
- Ohlsson C. (Claes)
- Oostra B.A. (Ben)
- Ordovas J.M.
- Pasquale L.R.
- Paynter N.P. (Nina)
- Pedersen N.L. (Nancy L.)
- PerÀlÀ M.-M.
- Peters U. (Ulrike)
- Power C. (Christine)
- Prokopenko I. (Inga)
- Psaty B.M. (Bruce)
- Raitakari O. (Olli)
- Rasheed A.
- Rawal R.
- Reed D.R.
- Renström F. (Frida)
- Ridker P.M. (Paul)
- Rimm E.B. (Eric B.)
- Rooij F.J.A. (Frank) van
- Rose L.M. (Lynda M.)
- Saleheen D.
- Siscovick D.S. (David)
- Snieder H. (Harold)
- Stolk R.P.
- Stumvoll M. (Michael)
- Tanaka T.
- Teumer A. (Alexander)
- Tiemeier H.W. (Henning)
- Treur J.L.
- Tucker K.L.
- Tönjes A. (Anke)
- Uitterlinden A.G. (André)
- Viikari J. (Jorma)
- Vink J.M.
- Vollenweider P.K. (Peter K.)
- Waldenberger M. (Melanie)
- Wang J.J.
- Wareham N.J. (Nick)
- Westra H.-J.
- Wojczynski M.K. (Mary )
- Wolffenbuttel B.H.R. (Bruce H. R.)
- Wright M.J. (Margaret)
- Xue L. (Luting)
- Yu K.
- Zhao J.H. (Jing Hua)
- Zonderman A.B.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
- Author
- Abecasis G. (Goncalo)
- Abecasis G.R. (Gonçalo)
- Abecasis G.R. (Gonçalo)
- Aben K.K.H. (Katja)
- Absher D. (Devin)
- Absher D. (Devin)
- Aherrahrou Z. (Zouhair)
- Ahlqvist E. (Emma)
- Ahmadi K.R. (Kourosh)
- Ahmed N. (Nabeel)
- Alavere H. (Helene)
- Alibrandi M.T.S. (Maria)
- Allayee H. (Hooman)
- Allen H.L.
- Almgren P. (Peter)
- Altshuler D. (David)
- Amin N. (Najaf)
- Anand S.S. (Sonia)
- Andersen K.K. (Karl)
- Ardissino D. (Diego)
- Ardlie K.G. (Kristin)
- Armitage J. (Jane)
- Arnold A.M. (Alice)
- Aspelund T. (Thor)
- Assimes T.L. (Themistocles)
- Assmann G. (Gerd)
- Aulchenko Y.S. (Yurii)
- Azhar M. (Muhammad)
- Balkau B. (Beverley)
- Ball S.G. (Stephen G.)
- Barbalic M. (maja)
- Barker A.M. (Adam)
- Barlassina C. (Christina)
- Barlera S. (Simona)
- Barnes D. (Daniel)
- Barnes T.A. (Timothy)
- Barrett A. (Angela)
- Barroso I.E. (InĂȘs)
- Bataille V. (Veronique)
- Becker D.M. (Diane)
- Becker L.C. (Lewis)
- Beckmann J.S. (Jacques)
- Beckmann J.S. (Jacques)
- Beilby J.P. (John)
- Bell J.T. (Jordana)
- Ben-Shlomo Y.
- Ben-Shlomo Y. (Yoav)
- Bennett A.J. (Amanda)
- Berger K. (Klaus)
- Bergman R.N. (Richard N.)
- Bergmann S.M. (Sven)
- Berndt S.I. (Sonja)
- Biebermann H. (Heike)
- Bis J.C. (Joshua)
- Blagieva R. (Roza)
- Blakemore A.I.F. (Alexandra)
- Blankenberg S. (Stefan)
- Boehm B.O. (Bernhard)
- Boehm B.O. (Bernhard)
- Boehnke M. (Michael)
- Boeing H. (Heiner)
- Boeing H. (Heiner)
- Boekholdt S.M. (Matthijs)
- Boerwinkle E.A. (Eric)
- Boes T. (Tanja)
- Bonnycastle L.L. (Lori)
- Boomsma D.I. (Dorret)
- Borecki I.B. (Ingrid)
- Bornstein S.R. (Stefan R.)
- Bornstein S.R. (Stefan)
- Boström K.B. (Kristina Bengtsson)
- Bouatia-Naji N. (Nabila)
- Bowman L.
- Braund P.S. (Peter)
- Bravenboer B. (Bert)
- Buchanan T.A. (Thomas)
- Bumpstead S. (Suzannah)
- Burnett M.S.
- Burtt N.P. (Noël)
- Busonero F.
- Buysschaert I. (Ian)
- Cambien F. (François)
- Campbell H. (Harry)
- Cappuccio F.P. (Francesco P.)
- Cappuccio F.P. (Francesco)
- Carlquist J.F. (John)
- Cauchi S. (Stephane)
- Caulfield M. (Mark)
- Cavalcanti-Proença C. (Christine)
- Chambers J.C. (John C.)
- Chambers J.C. (John)
- Chanock S.J. (Stephen)
- Charpentier G. (Guillaume)
- Chasman D.I. (Daniel)
- Chatterjee N. (Nilanjan)
- Chen C.-M. (Chih-Mei)
- Chen H. (Han)
- Chen L. (Li)
- Chines P.S. (Peter)
- Cichon S. (Sven)
- Clarke R.
- Clarke R. (Robert)
- Codd V. (Veryan)
- Coin L. (Lachlan)
- Coin L. (Lachlan)
- Collins F.S. (Francis S.)
- Collins F.S. (Francis)
- Collins F.S. (Francis)
- Connell J. (John)
- Cooper C. (Charles)
- Cooper C.C. (Cyrus C.)
- Cooper M.N. (Matthew N.)
- Cooper M.N. (Matthew)
- Cornelis M. (Marilyn)
- Couper D.J. (David)
- Crawford G. (Gabe)
- Cupples L.A. (Adrienne)
- Daly M.J. (Mark)
- Dam R.M. (Rob) van
- Danesh J. (John)
- Davies R.W. (Robert)
- Day I.N.M. (Ian N.M.)
- Day I.N.M. (Ian)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dedoussis G.V. (George)
- Dehghan A. (Abbas)
- Deloukas P. (Panagiotis)
- Demissie S. (Serkalem)
- Den Heijer M. (Martin)
- Dennison E.M. (Elaine)
- Dermitzakis E.T. (Emmanouil T.)
- Devaney J.M. (Joseph M.)
- Di Meglio P. (Paola)
- Diemert P. (Patrick)
- Dimas A.S. (Antigone)
- Dina C. (Christian)
- Dixon A.L. (Anna)
- Do R. (Ron)
- Doering A. (Angela)
- Doney A.S.F. (Alex)
- Donnelly P. (Peter)
- Duan J. (Jubao)
- Duijn C.M. (Cornelia) van
- Dupuis J. (Josée)
- Durbin R. (Richard)
- Ebrahim S. (Shah)
- Ebrahim S. (Shanil)
- Eifert S. (Sandra)
- Eiriksdottir G. (Gudny)
- El Mokhtari N.E. (Nour Eddine)
- Elliott A.L. (Amanda)
- Elliott K.S. (Katherine)
- Elliott P. (Paul)
- Ellis S.G. (Stephen)
- Elosua R. (Roberto)
- Engert J.C. (James C.)
- Epstein S.E. (Stephen)
- Erdmann J. (Jeanette)
- Erdos M.R. (Michael)
- Eriksson P. (Per)
- Esko T. (Tonu)
- Esko T. (TÔnu)
- Estrada Gil K. (Karol)
- Eury E. (Elodie)
- Faire U. (Ulf) de
- Farooqi I.S. (I. Sadaf)
- Farooqi I.S. (Sadaf)
- Farrall M. (Martin)
- Feitosa M.F. (Mary Furlan)
- Felix S.B. (Stephan)
- Ferrannini E. (Ele)
- Ferreira T. (Teresa)
- Fischer M. (Marcus)
- Fischer-Posovszky P. (Pamela)
- Florez J.C. (Jose)
- Folkersen L. (Lasse)
- Folsom A.R. (Aaron)
- Forsen T. (Tom)
- Fox C.S. (Caroline)
- Franklin C.S. (Christopher)
- Frants R.R. (Rune)
- Franzosi M.
- Frayling T.M. (Timothy)
- Freimer N.B. (Nelson B.)
- Freyer J. (Jennifer)
- Friedrich N. (Nele)
- Froguel P. (Philippe)
- Frossard R.
- Fu M. (Mao)
- Gaget S. (Stefan)
- Ganser M. (Martha)
- Gardezi A. (Ali)
- Gejman P.V. (Pablo)
- Geus E.J. (Eeco)
- Gieger C. (Christian)
- Gigante B. (Bruna)
- Girelli D. (Domenico)
- Gjesing A.P. (Anette)
- Glass D. (Daniel)
- Glazer N.L. (Nicole)
- Gloyn A.L. (Anna)
- Goddard M.E. (Michael E.)
- Goddard M.E. (Michael)
- Goel A. (Anuj)
- Goodall A.H. (Alison)
- Goyette P. (Philippe)
- Grallert H. (Harald)
- Grarup N. (Niels)
- Green F. (Fiona)
- Green T. (Todd)
- Greenawalt D.M. (Danielle M.)
- Griffin S. (Simon)
- Groop L. (Leif)
- Groop L. (Leif)
- Groop L. (Leif)
- Groves C.J. (Christopher)
- Grundberg E. (Elin)
- GrĂ€sler J. (JĂŒrgen)
- Grönberg H. (Henrik)
- Gu H.F. (Harvest F.)
- Gudnason V. (Vilmundur)
- Gudnason V. (Vilmundur)
- Guiducci C. (Candace)
- Gulcher J.R. (Jeffrey)
- Gustafsson S. (Stefan)
- Gyllensten U. (Ulf)
- Hadjadj S. (Samy)
- Haeften T.W. (Timon) van
- Hagen K. (Knut)
- Hall A.S. (Alistair S.)
- Hall P. (Per)
- Halperin E. (Eran)
- Hammond C.J. (Christopher J.)
- Hammond C.J. (Christopher)
- Hammond N. (Naomi)
- Hamsten A. (Anders)
- Hansen T. (T.)
- Haritunians T. (Talin)
- Harris T.B. (Tamara)
- Hartikainen A.-L. (Anna-Liisa)
- Hassanali N. (Neelam)
- Hattersley A.T. (Andrew)
- Havulinna A.S. (Aki)
- Hayes R.B. (Richard)
- Hayes R.B. (Richard)
- Hayward C. (Caroline)
- Hazen S.L. (Stanley)
- Heard-Costa N.L. (Nancy)
- Heath A.C. (Andrew C.)
- Hebebrand J. (Johannes)
- Hedman A.K. (Asa)
- Heid I.M. (Iris)
- Heijer M. (Martin) den
- Heinrich J. (Joachim)
- Hellénius M.-L. (Mai-Lis)
- Hengstenberg C. (Christian)
- Herder C. (Christian)
- Herpt T.W. (Thijs) van
- Hicks A.A. (Andrew)
- Hide W.A. (Winston)
- Hinney A. (Anke)
- Hirschhorn J.N. (Joel)
- Hitman G.A. (Graham)
- Hoek M. (Mandy) van
- Hoesel V. (Volker)
- Hofman A. (Albert)
- Hofmann O.M. (Oliver)
- Holm H. (Hilma)
- Homuth G. (Georg)
- Hopewell J.
- Horikoshi M. (Momoko)
- Hottenga J.J. (Jouke Jan)
- Hu F.B. (Frank)
- Hui J. (Jennie)
- Huikuri H.V. (Heikki)
- Hunter D.J. (David J.)
- Huth C. (Cornelia)
- Hveem K. (Kristian)
- Igl W. (Wilmar)
- Illig T. (Thomas)
- Illig T. (Thomas)
- Ingelsson E. (Erik)
- Iribarren C. (Carlos)
- Ishaq M. (Muhammad)
- Isomaa B. (Bo)
- Jackson A.U. (Anne)
- Jacobs K.B. (Kevin)
- James A. (Alan)
- Jameson K. (Karen)
- Jansson J.-O. (John-Olov)
- Jarick I. (Ivonne)
- Jarvelin M.-R. (Marjo-Riitta)
- Jewell E. (Eelizabeth)
- Johansson A. (Asa)
- John U. (Ulrich)
- Johnson P. (Paul)
- Johnson P.R.V. (Paul R.V.)
- Johnson T. (Toby)
- Johnson T. (Toby)
- Jones G.T. (Gregory)
- Jorgensen T. (Torben)
- Jousilahti P. (Pekka)
- Jukema J.W. (Jan Wouter)
- Jula A. (Antti)
- Kaakinen M. (Marika)
- Kajantie E. (Eero)
- Kanoni S. (Stavroula)
- Kao W.H.L. (Wen)
- Kaplan L. (Lee)
- Kaplan R.C. (Robert)
- Kaprio J. (Jaakko)
- Kaprio J. (Jaakko)
- Karpe F. (Fredrik)
- Karpe F. (Fredrik)
- Kastelein J.J.P. (John)
- Kathiresan S. (Sekar)
- Kerr-Conte J. (Julie)
- Kettunen J. (Johannes)
- Khaw K.T.
- Kiemeney L.A.L.M. (Bart)
- KilpelÀinen T.O. (Tuomas)
- Klopp N. (Norman)
- Knowles J.W. (Joshua)
- Kolovou G. (Genovefa)
- Kong A. (Augustine)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal S.)
- Kooner J.S. (Jaspal)
- Koskinen S. (Seppo)
- Kovacs P. (Peter)
- Kraft P. (Peter)
- Krude H.
- Kutalik Z. (ZoltĂĄn)
- Kuusisto J. (Johanna)
- Kyriakou T. (Theodosios)
- KÀhönen M. (Mika)
- König I.R. (Inke)
- Laakso M. (Markku)
- Laaksonen R. (Reijo)
- Laitinen J. (Jaana)
- Lambrechts D. (Diether)
- Lamina C. (Claudia)
- Langenberg C. (Claudia)
- Lantieri O. (Olivier)
- Lanzani C. (Chiara)
- Launer L.J. (Lenore)
- Lauritzen T. (Torsten)
- Lawlor D.A. (Debbie)
- Lawrence R.W. (Robert)
- Lecoeur C. (CĂ©cile)
- LehtimÀki T. (Terho)
- Lettre G. (Guillaume)
- Levinson D.F. (Douglas F.)
- Levinson D.F. (Douglas)
- Li M. (Man)
- Li S. (Shengxu)
- Li X. (Xiaohui)
- Liang L. (Liming)
- Lieb W. (Wolfgang)
- Lieverse A.G. (Aloysius)
- Linksted P. (Pamela)
- Liu J. (Jianjun)
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- Lokki M.L.
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- Loos R.J.F. (Ruth)
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- Luan J.
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- McCarthy M. (Mark)
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- McCarthy M.I. (Mark)
- McCulloch L.J. (Laura)
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- Morken M.A. (Mario)
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- Prokopenko I. (Inga)
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- Rybin D. (Denis)
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- Sabater-Lleal M. (Maria)
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- Shuldiner A.R. (Alan)
- Shuldiner A.R. (Alan)
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- Silander K. (Kaisa)
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- Sladek R. (Rob)
- Sleight P. (Peter)
- Smit J.H. (Jan)
- Smith A.V. (Albert Vernon)
- Smith A.V. (Albert)
- Smith A.V. (Davey)
- Smith T.B. (Tamara B.)
- Snoep J.D. (Jaapjan)
- Soranzo N. (Nicole)
- SparsĂž T. (Thomas)
- Spector T.D. (Timothy)
- Speliotes E.K. (Elizabeth)
- Spertus J.A. (John)
- StanÄcĂĄkovĂĄ A. (Alena)
- Stark K. (Klaus)
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- Stirrups K. (Kathy)
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- Strassburger K. (Klaus)
- Strawbridge R.J. (Rona)
- Strawbridge R.J. (Rona)
- Stringham H.M. (Heather)
- Stumvoll M. (Michael)
- Sun Q. (Qi)
- Surdulescu G. (Gabriela)
- Swift A.J. (Amy)
- SyvÀnen A.C.
- Tammesoo M.L.
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- Tang W. (W.)
- Tardif J.-C. (Jean-Claude)
- Tennstedt S. (Stephanie)
- Teslovich T.M. (Tanya M.)
- Thiering E. (Eelisabeth)
- Thiering E. (Elisabeth)
- Thompson J.R. (John)
- Thomson B. (Brian)
- Thorand B. (Barbara)
- Thorand B. (Barbara)
- Thorgeirsson G. (Gudmundur)
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- Vliet-Ostaptchouk J.V. (Jana) van
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- Widen E. (Elisabeth)
- Wiegand S. (Susanna)
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- Wiklund F. (Fredrik)
- Wild P.S. (Philipp)
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- Willemsen G.A.H.M. (Gonneke)
- Willenborg C. (Christina)
- Willer C.J. (Cristen)
- Wilson J.F. (James F.)
- Wingerden S. (Sophie) van
- Winkler T.W. (Thomas W.)
- Witte D.R. (Daniel R.)
- Witte D.R. (Deniel)
- Witteman J. (Jacqueline)
- Witteman J.C.M. (Jacqueline)
- Witteman J.C.M. (Jaqueline C.M.)
- Wood A.R. (Andrew)
- Workalemahu T. (Tsegaselassie)
- Wright A.F. (Alan)
- Wright B.J. (Benjamin)
- Wu G. (Guanming)
- Xie W. (Weijia)
- Xu J. (Jianfeng)
- Yang J. (Jian)
- Yang J. (Joanna)
- Yang T.-P. (Tsun-Po)
- Ye S. (Shu)
- Zabena C. (Carina)
- Zaidi M.A. (Aghar)
- Zaman K.S. (Khan Shah)
- Zeggini E. (Eleftheria)
- Zeller T. (Tanja)
- Zethelius B. (Björn)
- Zgaga L. (Lina)
- Zhang Q. (Qunyuan)
- Zhang W. (Weihua)
- Zhao J.H. (Jing Hua)
- Ziegler A. (Andreas)
- Ziegler A. (Andreas)
- Zillikens M.C. (Carola)
- Zitting P. (Paavo)
- Zondervan K.T. (Krina T.)
- Zondervan K.T. (Krina)
- Zwart J-A. (John-Anker)
- Ăhrvik J. (John)
- Ăstenson C.-G. (Claes-Göran)
- Publication venue
- Publication date
- 01/10/2011
- Field of study
OBJECTIVE - Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired b-cell function, raised glucose levels, insulin resistance, and type 2 diabetes (T2D). Studies of the insulin processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS - We have conducted a meta-analysis of genome-wide association tests of ;2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) and fasting proinsulin levels in 10,701 nondiabetic adults of European ancestry, with follow-up of 23 loci in up to 16,378 individuals, using additive genetic models adjusted for age, sex, fasting insulin, and study-specific covariates. RESULTS - Nine SNPs at eight loci were associated with proinsulin levels (P < 5 Ă 10-8). Two loci (LARP6 and SGSM2) have not been previously related to metabolic traits, one (MADD) has been associated with fasting glucose, one (PCSK1) has been implicated in obesity, and four (TCF7L2, SLC30A8, VPS13C/ C2CD4A/B, and ARAP1, formerly CENTD2) increase T2D risk. The proinsulin-raising allele of ARAP1 was associated with a lower fasting glucose (P = 1.7 3 10-4), improved b-cell function (P = 1.1 Ă 10-5), and lower risk of T2D (odds ratio 0.88; P = 7.8 Ă 10-6). Notably, PCSK1 encodes the protein prohormone convertase 1/3, the first enzyme in the insulin processing pathway. A genotype score composed of the nine proinsulin-raising alleles was not associated with coronary disease in two large case-control datasets. CONCLUSIONS - We have identified nine genetic variants associated with fasting proinsulin. Our findings illuminate the biology underlying glucose homeostasis and T2D development in humans and argue against a direct role of proinsulin in coronary artery disease pathogenesis