Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the interaction between infected erythrocytes and endothelium. This is a complex system involving several host receptors and a major parasite-derived variant antigen (PfEMP1) expressed on the surface of the infected erythrocyte membrane. Previous studies have suggested a role for ICAM-1 in the pathology of cerebral malaria, although these have been inconclusive. In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases

Jovian Electrons in the Inner Heliosphere: Opportunities for Multi-spacecraft Observations and Modeling

In this paper we explore the idea of using multi-spacecraft observations of Jovian electrons to measure the 3D distribution of these particles in the inner heliosphere. We present simulations of Jovian electron intensities along selected spacecraft trajectories for 2021 and compare these, admittedly qualitatively, to these measurements. Using the data-model comparison we emphasize how such a study can be used to constrain the transport parameters in the inner heliosphere, and how this can lead to additional insight into energetic particle transport. Model results are also shown along the expected trajectories of selected spacecraft, including the off-ecliptic phase of the Solar Orbiter mission from 2025 onward. Lastly, we revisit the use of historical data and discuss upcoming missions that may contribute to Jovian electron measurements.</p