Nanotechnology and Drug Delivery Part 2: Nanostructures for Drug Delivery

This is the second part of a review on nanotechnology in general and particularly as it pertains to drug deliver. In the earlier paper (Part 1), nanotechnology in nature, its history as well as design and methodswere discussed. Its applications, benefits and risks were also outlined. In this paper (Part 2), various nanostructures employed in drug delivery, their methods of fabrication and challenges of nano drug delivery are reviewed. Nanotechnology is one approach to overcome challenges of conventional drugdelivery systems based on the development and fabrication of nanostructures. Some challenges associated with the technology as it relates to drug effectiveness, toxicity, stability, pharmacokinetics and drug regulatory control are discussed in this review. Clearly, nanotechnology is a welcomedevelopment that is set to transform drug delivery and drug supply chain management, if optimally developed

An assessment of pharmaceutical waste management in some Nigerian pharmaceutical industries

Thirty four (34) of the fifty (50) selected Nigerian based pharmaceutical businesses, mainly acting as local manufacturers and major importers of medicines were interviewed using questionnaires to ascertain their waste management practices, knowledge of waste management policies and subjection to regulatory control. This study indicated that like its counterpart industry in other countries of the world, the Nigerian pharmaceutical industry generated both hazardous and non-hazardous wastes. However, the wastes were not categorized, poorly managed by 91.2% of the respondents, while 58.8% of the health and safety personnel had little or no modern knowledge of waste management. Furthermore, 73.5% of the respondents claimed that they were aware of the regulatory requirements on waste, but no adherence was observed. The industry did not benefit from the strict supervisions of regulatory agencies. Pharmaceutical waste was improperly disposed and all the secondary manufacturers (79.4%) discharged wastewater without removal of pharmaceuticals. This study highlighted the urgent need to train personnel in the pharmaceutical industry and regulatory authorities. Management of waste should be planned, documented, implemented and sustained.Key words: Pharmaceutical waste, pharmaceuticals, wastewater, waste management, environment, regulatory authorities, effluent

Nanotechnology and Drug Delivery Part 1: Background and Applications

Nanotechnology in general and as it relates to drug delivery in humans has been reviewed in a two-part article, the first part of which is this paper. In this paper, nanotechnology in nature, history of nanotechnology and methods of synthesis are discussed, while also outlining its applications, benefits and risks. Nanotechnology is an industrial revolution, based on integration of disciplines that could change every facet of human life. Some examples ofchanges brought about by reduction in particle sizes to the physical, chemical and biological properties of substances, compounds and drug products have been cited. The benefits of nanotechnology are enormous and so these benefits should be maximized while efforts are made to reduce the risks