28 research outputs found
Phenotypic divergence of Jagged I and NOTCH 2 associated Algille syndrome: results from the international multicenter GALA study group.
QTL for the iron and zinc contents of the milled grains of a doubled-haploid rice (Oryza sativa L.) population grown over two seasons
Coverage of Adequately Iodized Salt Is Suboptimal and Rice Fortification Using Public Distribution Channels Could Reach Low-Income Households: Findings from a Cross-Sectional Survey of Anganwadi Center Catchment Areas in Telangana, India
Influence of Jagged1 on apoptosis-related gene expression: a microarray database analysis
Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
A light-gated potassium channel for sustained neuronal inhibition
Currently available inhibitory optogenetic tools provide short and transient silencing of neurons, but they cannot provide long-lasting inhibition because of the requirement for high light intensities. Here we present an optimized blue-light-sensitive synthetic potassium channel, BLINK2, which showed good expression in neurons in three species. The channel is activated by illumination with low doses of blue light, and in our experiments it remained active over (tens of) minutes in the dark after the illumination was stopped. This activation caused long periods of inhibition of neuronal firing in ex vivo recordings of mouse neurons and impaired motor neuron response in zebrafish in vivo. As a proof-of-concept application, we demonstrated that in a freely moving rat model of neuropathic pain, the activation of a small number of BLINK2 channels caused a long-lasting (>30 min) reduction in pain sensation