Mutagenic replication: target for tumor therapy?

A study published in Cell by Wojtaszek et al. provides a proof of principle that cancer cells can be sensitized to DNA-damaging chemotherapy by the drug-induced inhibition of mutagenic DNA translesion synthesis, a process that endows tolerance of DNA damage. However, the risk/benefit profile of such a combination therapy should be thoroughly evaluated.Genome Instability and Cance