A review on experimental pharmacology

In this era where the pharmaceutical companies and products are hiking in its need and production it is inevitable to document the safety and toxicity along with the indications of the same. This is where the experimental study has a vital role to play. Experimental pharmacology is the science where the drug interaction with different receptors and target sites in living organism are explained. This article reviews about the different aspects of experimental pharmacology and its uses.   Keywords: Experimental pharmacology, products, dosag

Vyana Vata – The Mahajava

Vyana Vata is described as Mahajava which is highly powerful. Therefore it keeps the Rasa Dhatu in circulation continuously and always throughout the life. Vyana Vata with its swift action performs all the functions in the body. All the three Doshas residing in Hrdaya contribute directly or indirectly to the functioning of the body; but vyana vata has a unique role in carrying out the functions throughout the body while residing in hrdaya. Any obstruction to vyana vata leads to a disease that affects the whole body. Vitiation of vyana vata hampers its functions as well as nutrition and movements of the body. Therefore treatment should aim at understanding vyana vata and to correct the root cause. The paper describes the physiological, pathological and treatment aspects of vyana vata in accordance with the contemporary view. The physiological aspect includes the location, functions and dependency of other sub types of Vata to Vyana Vata which is discussed along with its contemporary understanding. The pathological aspect deals with causes for vitiation and symptoms seen and the general line of treatment modality applied

THE ROLE OF HERBAL IMMUNOMODULATORS AS ADJUVANT THERAPY FOR ASYMPTOMATIC AND MILDLY SYMPTOMATIC COVID-19: AN EXPLORATORY CLINICAL STUDY

Objectives: The objective of the study is to evaluate herbal immunomodulators (Septilin and Bresol) as a possible adjuvant therapy for the treatment of asymptomatic and mildly symptomatic COVID-19. Methods: Randomized, open-label, comparative clinical study. Subjects were randomized to either arm I [Septilin and Bresol+standard of care (SOC)] or arm II (SOC). This study was registered on CTRI (CTRI/2020/06/025801). Results: Subjects in arm I showed a greater reduction in levels of interleukin-6 tumor necrosis factor-α following treatment than in arm II. Subjects in arm I showed a greater increase in levels of interferon (IFN)-β and IFN-λ than those in arm II. There was a greater reduction in D-dimer in arm I than in arm II subjects (64.28% vs. 35.59%) and all arm I subjects had D-dimer values in the normal range compared to 70% of arm II subjects. There were statistically significant reduction in lactate dehydrogenase and neutrophil-to-lymphocyte ratio in arm I (p<0.016 and p<0.013, respectively). Clinical assessments during the post-illness convalescence period showed significant improvements in fatigue assessment scores and quality of life. Conclusion: This herbal combination as an adjuvant to SOC may provide additional long-term benefits in COVID-19 infection by reducing inflammation. This treatment may offer a good addendum for the management of post-COVID-19 illness