2,028 research outputs found
<Abstract of Published Report>Experimental prevention of the contamination with nonthuberculous Mycobacteria in the 24h-bath systems. : Use of autoclaved porous filter balls
Five-dimensional AGT Conjecture and the Deformed Virasoro Algebra
We study an analog of the AGT relation in five dimensions. We conjecture that
the instanton partition function of 5D N=1 pure SU(2) gauge theory coincides
with the inner product of the Gaiotto-like state in the deformed Virasoro
algebra. In four dimensional case, a relation between the Gaiotto construction
and the theory of Braverman and Etingof is also discussed.Comment: 12 pages, reference added, minor corrections (typos, notation
changes, etc
Heterozygosity increases microsatellite mutation rate, linking it to demographic history
<p>Abstract</p> <p>Background</p> <p>Biochemical experiments in yeast suggest a possible mechanism that would cause heterozygous sites to mutate faster than equivalent homozygous sites. If such a process operates, it could undermine a key assumption at the core of population genetic theory, namely that mutation rate and population size are indpendent, because population expansion would increase heterozygosity that in turn would increase mutation rate. Here we test this hypothesis using both direct counting of microsatellite mutations in human pedigrees and an analysis of the relationship between microsatellite length and patterns of demographically-induced variation in heterozygosity.</p> <p>Results</p> <p>We find that microsatellite alleles of any given length are more likely to mutate when their homologue is unusually different in length. Furthermore, microsatellite lengths in human populations do not vary randomly, but instead exhibit highly predictable trends with both distance from Africa, a surrogate measure of genome-wide heterozygosity, and modern population size. This predictability remains even after statistically controlling for non-independence due to shared ancestry among populations.</p> <p>Conclusion</p> <p>Our results reveal patterns that are unexpected under classical population genetic theory, where no mechanism exists capable of linking allele length to extrinsic variables such as geography or population size. However, the predictability of microsatellite length is consistent with heterozygote instability and suggest that this has an important impact on microsatellite evolution. Whether similar processes impact on single nucleotide polymorphisms remains unclear.</p
Sidelobe reduction of unequally spaced arrays for 5G applications
Unequally spaced arrays technique offers an alternative for limited sidelobe level reduction compared to conventional array antennas with equally spaced elements. In this paper, the abilities and design of microstrip linear array antenna, fed by multiport feeding with uniform excitation coefficient in all array elements are presented for sidelobe level reduction at 28 GHz. By using the proximity coupled feed, simulation result gave -10 dB impedance bandwidth of 1.42 GHz and reflection coefficient of -35.5 dB has been achieved. The sidelobe level at broadside decreased from -11.77 dB to -14.76 dB (N = 4) and -12.77 dB to -15.98 dB (N = 8) with unequally spaced array. This feature is suitable for 5G applications
Transforming growth factor beta-1 (TGFB1) and peak bone mass: association between intragenic polymorphisms and quantitative ultrasound of the heel
BACKGROUND: Variance of peak bone mass has a substantial genetic component, as has been shown with twin studies examining quantitative measures such as bone mineral density (BMD) and quantitative ultrasound (QUS). Evidence implicating single nucleotide polymorphisms (SNPs) of the transforming growth factor beta-1 (TGFB1) gene is steadily accumulating. However, a comprehensive look at multiple SNPs at this locus for their association with indices of peak bone mass has not been reported. METHODS: A cohort of 653 healthy Caucasian females 18 to 35 years old was genotyped for seven TGFB1 SNPs. Polymorphisms were detected by restriction endonuclease digestion of amplified DNA segments. RESULTS: The frequencies of the least common allele at G-800A, C-509T, codon 10 (L10P), codon 25 (R25P), codon 263 (T263I), C861-20T, and 713-8 delC loci were 0.07, 0.33, 0.41, 0.08, 0.04, 0.25 and 0.01, respectively. A significant association was seen between QUS Stiffness Index (QUS-SI) and the SNP at codon 10 and the linked promoter SNP, C-509T. This association remained significant after multiple regression was used to incorporate important clinical covariates – age, BMI, level of activity, family history, and caffeine intake – into the model. CONCLUSION: The association of QUS-SI with -509T is consistent with a gene-dose effect, while only individuals homozygous for the codon 10P allele showed a significant increase. In this cohort of young healthy Caucasian females, the T allele at position -509 is associated with greater bone mass as measured by calcaneal ultrasound
Full nonperturbative QCD simulations with 2+1 flavors of improved staggered quarks
Dramatic progress has been made over the last decade in the numerical study
of quantum chromodynamics (QCD) through the use of improved formulations of QCD
on the lattice (improved actions), the development of new algorithms and the
rapid increase in computing power available to lattice gauge theorists. In this
article we describe simulations of full QCD using the improved staggered quark
formalism, ``asqtad'' fermions. These simulations were carried out with two
degenerate flavors of light quarks (up and down) and with one heavier flavor,
the strange quark. Several light quark masses, down to about 3 times the
physical light quark mass, and six lattice spacings have been used. These
enable controlled continuum and chiral extrapolations of many low energy QCD
observables. We review the improved staggered formalism, emphasizing both
advantages and drawbacks. In particular, we review the procedure for removing
unwanted staggered species in the continuum limit. We then describe the asqtad
lattice ensembles created by the MILC Collaboration. All MILC lattice ensembles
are publicly available, and they have been used extensively by a number of
lattice gauge theory groups. We review physics results obtained with them, and
discuss the impact of these results on phenomenology. Topics include the heavy
quark potential, spectrum of light hadrons, quark masses, decay constant of
light and heavy-light pseudoscalar mesons, semileptonic form factors, nucleon
structure, scattering lengths and more. We conclude with a brief look at highly
promising future prospects.Comment: 157 pages; prepared for Reviews of Modern Physics. v2: some rewriting
throughout; references update
Effects of the Molecular Weight and the Degree of Deacetylation of Chitosan Oligosaccharides on Antitumor Activity
Effects of the degree of deacetylation (DDA) and the molecular mass of chitosan oligosaccharides (CTS-OS), obtained from the enzymatic hydrolysis of high molecular weight chitosan (HMWC), on antitumor activity was explored. The DDA and molecular weights of CTS-OS were determined by matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-TOF MS) analysis. The CTS-OS were found to be a mixture of mainly dimers (18.8%), trimers (24.8%), tetramers (24.9%), pentamers (17.7%), hexamers (7.1%), heptamers (3.3%), and octamers (3.4%). The CTS-OS were further fractionated by gel-filtration chromatography into two major fractions: (1) COS, consisting of glucosamine (GlcN)n, n = 3–5 with DDA 100%; and (2) HOS, consisting of (GlcN)5 as the minimum residues and varying number of N-acetylglucosamine (GlcNAc)n, n = 1–2 with DDA about 87.5% in random order. The cytotoxicities, expressed as the concentration needed for 50% cell death (CC50), of CTS-OS, COS, and HOS against PC3 (prostate cancer cell), A549 (lung cancer cell), and HepG2 (hepatoma cell), were determined to be 25 μg·mL−1, 25 μg·mL−1, and 50 μg·mL−1, respectively. The HMWC was approximately 50% less effective than both CTS-OS and COS. These results demonstrate that the molecular weight and DDA of chitosan oligosaccharides are important factors for suppressing cancer cell growth
A ferroelectric memristor
Memristors are continuously tunable resistors that emulate synapses.
Conceptualized in the 1970s, they traditionally operate by voltage-induced
displacements of matter, but the mechanism remains controversial. Purely
electronic memristors have recently emerged based on well-established physical
phenomena with albeit modest resistance changes. Here we demonstrate that
voltage-controlled domain configurations in ferroelectric tunnel barriers yield
memristive behaviour with resistance variations exceeding two orders of
magnitude and a 10 ns operation speed. Using models of ferroelectric-domain
nucleation and growth we explain the quasi-continuous resistance variations and
derive a simple analytical expression for the memristive effect. Our results
suggest new opportunities for ferroelectrics as the hardware basis of future
neuromorphic computational architectures
Cultural adaptation and validation of the Freiburg Life Quality Assessment - Wound Module to Brazilian Portuguese
The Howl - Fall 2016
The Howl is a magazine that is planned, researched, written, photographed and designed by Otterbein University\u27s ESL and international students. The magazine serves to give them a safe space in which to use their voice to share their cultures, experiences and lives. If you are interested in submitting to The Howl, please email your writing or photography to [email protected]://digitalcommons.otterbein.edu/the_howl/1001/thumbnail.jp
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