18 research outputs found
RBE of "Prometeus" Facility Protons for Irradiation of Tumor Cells in vitro with One and Three Fields
The study was aimed to the biological effectiveness of the proton scanning beam of the first Russian medical facility. The clonogenic assay of B-16 tumor cells was used as a test system. Cell irradiation was carried out in a suspension condition in a water phantom. Single and three-field exposures were studied. The dose interval was 2-8 Gy. The energy range from 47.5 to 92.0 MeV was used for the Bragg peak formation. The relative biological effectiveness of protons comparing to gamma-rays was 1.2 for single-field and 1.5 for three-field irradiation. The results obtained agree with literature data related to the used cell culture (B-16) and linear energy transfer range (3Γ·8 keV/Β΅m)
Ξ²-ΠΠ°ΡΠ΅Π½ΠΈΠ½: ΡΡΡΡΠΊΡΡΡΠ°, ΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ ΡΠΎΠ»Ρ Π² ΠΎΠΏΡΡ ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ ΠΊΠ»Π΅ΡΠΎΠΊ
The article presents the data on the structure and mechanisms of Ξ²-Ρatenin functioning. The basic aspects of the role of Ξ²-Ρatenin in malignant transformation have been studied at various tumors. Primary structure of Ξ²-catenin allows it to interact with many factors and ligands, including transcription factors, Ξ±-catenin, cadherin, Axin, Rho family GTPases, Bcl9 et al. This interaction is the base for Ξ²-catenin's intracellular multifunctioning. The review presents data on the participation of Ξ²-catenin in the mechanisms of adhesion, regulation of RNA metabolism, formation contacts with the cytoskeleton and its role in the canonical Wnt signaling pathway, marked examples pro-inflammatory and anti-inflammatory effects of Ξ²-catenin. The Ξ²-catenin involvement in malignant transformation and progression of certain tumors is not in doubt. The data on the changes in Ξ²-catenin expression in the given examples of colon cancer, prostate cancer, different forms of thyroid cancer and hepatocellular carcinoma are presented with the prospects of its use as a marker and a predictor of malignant transformation. Continued research in this area will not only make use of Ξ²-catenin as a potential predictor of malignant tumors, but also to develop approaches to targeted therapy.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΎ ΡΡΡΡΠΊΡΡΡΠ΅ ΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Ξ²-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½Π°, Π΅Π³ΠΎ ΡΠΎΠ»ΠΈ Π² ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΏΡΠΈ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π²Π°ΡΠΈΠ°Π½ΡΠ°Ρ
Π½Π΅ΠΎΠΏΠ»Π°Π·ΠΈΠΉ. ΠΠ΅ΡΠ²ΠΈΡΠ½Π°Ρ ΡΡΡΡΠΊΡΡΡΠ° Ξ²-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½Π° ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΅ΠΌΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠΎ ΠΌΠ½ΠΎΠ³ΠΈΠΌΠΈ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ ΠΈ Π»ΠΈΠ³Π°Π½Π΄Π°ΠΌΠΈ, Π² Ρ.Ρ. Ρ ΡΠ°ΠΊΡΠΎΡΠ°ΠΌΠΈ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΈ, Ξ±-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½ΠΎΠΌ, Π±Π΅Π»ΠΊΠΎΠΌ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠΉ Π°Π΄Π³Π΅Π·ΠΈΠΈ ΠΊΠ°Π΄Π³Π΅ΡΠΈΠ½ΠΎΠΌ, Axin, ΠΌΠ°Π»ΡΠΌΠΈ ΠΠ’Π€Π°Π·Π°ΠΌΠΈ ΡΠ΅ΠΌΠ΅ΠΉΡΡΠ²Π° Rho, Bcl9 ΠΈ Π΄Ρ. ΠΡΠ΅ ΡΡΠΎ ΠΎΠ±ΡΡΡΠ½ΡΠ΅Ρ Π΅Π³ΠΎ Π²Π½ΡΡΡΠΈΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ ΠΌΠ½ΠΎΠ³ΠΎΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΡΡΡ. Π’Π°ΠΊΠΆΠ΅ ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΡΡΠ°ΡΡΠΈΠΈ Ξ²-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½Π° Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
Π°Π΄Π³Π΅Π·ΠΈΠΈ, ΡΠ΅Π³ΡΠ»ΡΡΠΈΠΈ ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΠ·ΠΌΠ° Π ΠΠ, ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΠ½ΡΠ°ΠΊΡΠΎΠ² Ρ ΡΠΈΡΠΎΡΠΊΠ΅Π»Π΅ΡΠΎΠΌ, Π΅Π³ΠΎ ΡΠΎΠ»ΠΈ ΠΊΠ°ΠΊ ΠΊΠΎΡΠ°ΠΊΡΠΎΡΠ° Π² ΠΊΠ°Π½ΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΌ Wnt-ΡΠΈΠ³Π½Π°Π»ΡΠ½ΠΎΠΌ ΠΏΡΡΠΈ; ΠΏΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΠΏΡΠΈΠΌΠ΅ΡΡ ΠΏΡΠΎ- ΠΈ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² Ξ²-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½Π°. Π£ΡΠ°ΡΡΠΈΠ΅ Ξ²-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½Π° Π² ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΈ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π΅ Π²ΡΠ·ΡΠ²Π°Π΅Ρ ΡΠΎΠΌΠ½Π΅Π½ΠΈΠΉ. ΠΡΠ²Π΅ΡΠ΅Π½Ρ ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΡ ΠΎΠ± ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ Ξ²-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½Π° ΠΏΡΠΈ ΡΠ°ΠΊΠΈΡ
ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΡ
Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»ΡΡ
, ΠΊΠ°ΠΊ ΡΠ°ΠΊ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠΈΡΠΊΠΈ, ΡΠ°ΠΊ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ Π²Π°ΡΠΈΠ°Π½ΡΡ ΡΠ°ΠΊΠ° ΡΠΈΡΠΎΠ²ΠΈΠ΄Π½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, Π³Π΅ΠΏΠ°ΡΠΎΡΠ΅Π»Π»ΡΠ»ΡΡΠ½ΡΠΉ ΡΠ°ΠΊ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π°Ρ
Π΅Π³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΊΠ°ΠΊ ΠΌΠ°ΡΠΊΠ΅ΡΠ° ΠΈ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠ° Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ. ΠΡΠΎΠ΄ΠΎΠ»ΠΆΠ΅Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² Π΄Π°Π½Π½ΠΎΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ Ξ²-ΠΊΠ°ΡΠ΅Π½ΠΈΠ½ ΠΊΠ°ΠΊ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΉ ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ, Π½ΠΎ ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΠΈΡ
ΡΠ°ΡΠ³Π΅ΡΠ½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈ
EFFICACY AND SAFETY OF IRRIGATION SPRAY APPLICATION FOR THE THROAT IN COMPLEX THERAPY OF INFLAMMATORY OROPHARYNX DISEASES IN CHILDREN
Inflammatory diseases of the oropharynx manifested with pain or discomfort in the throat, is a frequent pathology in children. Traditionally, patients with acute and exacerbation of chronic tonsillitis and pharyngitis are prescribed gargarism. In recent years, the use of sea water-based throat sprays have been allowed for irrigation therapy. Their use as part of the complex treatment of inflammatory oropharynx diseases statistically reliably decreases the intensity of pain reaction on the 10thβ24th day of treatment compared to conventional gargarism and is comparable with conventional therapy when assessing other clinical symptoms. It is therefore possible to recommend using sea water-based substance as a initial means of irrigation therapy in the complex treatment of inflammatory oropharynx diseases in children.Key words: pharyngitis, tonsillitis, throat pain, irrigation therapy, children
EFFICACY AND SAFETY OF IRRIGATION SPRAY APPLICATION FOR THE THROAT IN COMPLEX THERAPY OF INFLAMMATORY OROPHARYNX DISEASES IN CHILDREN
Inflammatory diseases of the oropharynx manifested with pain or discomfort in the throat, is a frequent pathology in children. Traditionally, patients with acute and exacerbation of chronic tonsillitis and pharyngitis are prescribed gargarism. In recent years, the use of sea water-based throat sprays have been allowed for irrigation therapy. Their use as part of the complex treatment of inflammatory oropharynx diseases statistically reliably decreases the intensity of pain reaction on the 10thβ24th day of treatment compared to conventional gargarism and is comparable with conventional therapy when assessing other clinical symptoms. It is therefore possible to recommend using sea water-based substance as a initial means of irrigation therapy in the complex treatment of inflammatory oropharynx diseases in children.Key words: pharyngitis, tonsillitis, throat pain, irrigation therapy, children
Morphological substantiation of laparoscopic suturing of stomach ulcer with formation of a covered perforation
Objective. Morphological substantiation of laparoscopic suturing of gastric ulcer with formation of a covered perforation. Material and methods. To analyze morphological tissue reaction in surgical area, we used 12 Chinchilla rabbits. All animals were divided into 2 groups by 6 animals. The main group enrolled rabbits undergoing suturing of perforated gastric ulcer with formation of a covered perforation by anterior stomach wall. In the control group, gastric perforation was sutured by conventional double-row suture. For histological analysis, 2 animals in each group were withdrawn from the experiment after 7, 14 and 21 days. We excised gastric wall within the area of perforation closure. Morphological data on healing process were compared between both groups. Results. Stomach deformation after 7 days was more severe in the main group compared to simple suturing. However, these dif- ferences were absent after 21 days. Morphological analysis revealed postoperative transmural necrosis after 7 days. Signs of early epithelialization were more obvious in the main group. After 21 postoperative days, we observed almost completely restored dif- ferentiation of stomach wall layers in both groups of animals. Β© 2022, Media Sphera Publishing Group. All rights reserved