5 research outputs found
Suppression of NADH dehydrogenase activity and semiquinone free radicals level as well as ROS production in human erythroleukemia K562 cells upon development of resistance to doxorubicin
- Publication venue
- Wiley-Blackwell
- Publication date
- Field of study
No full textChanges in expression of genes encoding antioxidant enzymes, heme oxygenase-1, Bcl-2, and Bcl-xl and in level of reactive oxygen species in tumor cells resistant to doxorubicin
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- 03/03/2020
- Field of study
No full textThe relationship between expression of genes encoding key antioxidant enzymes, heme oxygenase-1, Bcl-2, and Bcl-xl and change in production of reactive oxygen species (ROS) resulting from development of resistance of cancer cells K562, MCF-7, and SKOV-3 to the prooxidant chemotherapeutic agent doxorubicin (DOX) has been studied. Significant increase in mRNA level and activity of Mn-superoxide dismutase (Mn-SOD), catalase, and selenium-dependent glutathione peroxidase-1 (GPx-1) and reduced ROS level was found in resistant K562/DOX and SKVLB cells. In contrast, no change in ROS level was observed in MCF-7/DOX cells in parallel with decrease in Mn-SOD and catalase mRNAs and corresponding activities concurrently with high increase in GPx-1 mRNA and activity. As a result of the development of resistance, a similarity was found between the change in ROS level and the change in ho-1 and bcl-2 gene expression, whereas elevation of bcl-xl gene expression was observed in all three types of resistant cells. Particular features of development of adaptive antioxidant response as well as redox-dependent change in bcl-2 gene expression under formation of DOX resistance of cancer cells of different genesis are discussed. © Nauka/Interperiodica 2006
Changes in expression of genes encoding antioxidant enzymes, heme oxygenase-1, Bcl-2, and Bcl-xl and in level of reactive oxygen species in tumor cells resistant to doxorubicin
- Publication venue
- 'Pleiades Publishing Ltd'
- Publication date
- Field of study
No full textThe relationship between expression of genes encoding key antioxidant enzymes, heme oxygenase-1, Bcl-2, and Bcl-xl and change in production of reactive oxygen species (ROS) resulting from development of resistance of cancer cells K562, MCF-7, and SKOV-3 to the prooxidant chemotherapeutic agent doxorubicin (DOX) has been studied. Significant increase in mRNA level and activity of Mn-superoxide dismutase (Mn-SOD), catalase, and selenium-dependent glutathione peroxidase-1 (GPx-1) and reduced ROS level was found in resistant K562/DOX and SKVLB cells. In contrast, no change in ROS level was observed in MCF-7/DOX cells in parallel with decrease in Mn-SOD and catalase mRNAs and corresponding activities concurrently with high increase in GPx-1 mRNA and activity. As a result of the development of resistance, a similarity was found between the change in ROS level and the change in ho-1 and bcl-2 gene expression, whereas elevation of bcl-xl gene expression was observed in all three types of resistant cells. Particular features of development of adaptive antioxidant response as well as redox-dependent change in bcl-2 gene expression under formation of DOX resistance of cancer cells of different genesis are discussed. © Nauka/Interperiodica 2006
Intraplate basic-ultrabasic magmatism through time in terms of supercontinental cyclicity
- Author
- A. Davidson
- A. Hofmann
- A. Min de
- A.E. Isoh
- A.K. Hickman
- A.L. Ahmat
- A.N. Nikishin
- A.P. Nutman
- B. Bingen
- B. He
- C. Morimoto
- C. O’Neill
- C.E. Isachsen
- C.F. Ferreira-Filho
- D.L. Anderson
- D.M. Hoatson
- D.R. Nelson
- F. Corfu
- F.J. Baars
- G. Dessureau
- G.R. Byerly
- H.C. Halls
- I. McDougall
- I.S. Puhtel
- J. Lei
- J. Zhao
- J.E. French
- J.E. French
- J.F. Wilson
- J.G. Meert
- J.M. Barton Jr.
- J.M. Rao
- J.P.P. Pinese
- J.S. Myers
- K. Hegner
- K.L. Buchan
- L. Hanley
- L.B. Aspler
- L.M. Heaman
- M. Jayananda
- M. Ramakrishnan
- M.D. Higgins
- M.E. Barley
- M.F. Coffin
- M.J. Kranendonk Van
- M.J. Kranendonk Van
- M.T.D. Wingate
- M.T.D. Wingate
- N. A. Bozhko
- N. Coltice
- N.P. Scherbak
- O.M. Svenningsen
- P. A. Ziegler
- P.G. Eriksson
- R. Mazumder
- R.A. Armstrong
- R.E. Ernst
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- R.E. Ernst
- R.E. Ernst
- R.E. Ernst
- R.E. Ernst
- R.L. Romer
- R.P. Barnes
- R.S. Selbekk
- S.B. Lobach-Zhuchenko
- S.D. Lobach-Zhuchenko
- T. Radhakrishna
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- V.E. Courtillot
- V.E. Pavlov
- X. Qian
- Y.J.R. Rao
- Yu.A. Balashov
- Yu.V. Amelin
- Publication venue
- 'Allerton Press'
- Publication date
- Field of study
No full textBibliography
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