174 research outputs found
Meta-stable memory in an artificial immune network
Abstract. This paper describes an artificial immune system algorithm which implements a fairly close analogue of the memory mechanism proposed by Jerne(1) (usually known as the Immune Network Theory). The algorithm demonstrates the ability of these types of network to produce meta-stable structures representing populated regions of the antigen space. The networks produced retain their structure indefinitely and capture inherent structure within the sets of antigens used to train them. Results from running the algorithm on a variety of data sets are presented and shown to be stable over long time periods and wide ranges of parameters. The potential of the algorithm as a tool for multivariate data analysis is also explored.
Bell's theorem as a signature of nonlocality: a classical counterexample
For a system composed of two particles Bell's theorem asserts that averages
of physical quantities determined from local variables must conform to a family
of inequalities. In this work we show that a classical model containing a local
probabilistic interaction in the measurement process can lead to a violation of
the Bell inequalities. We first introduce two-particle phase-space
distributions in classical mechanics constructed to be the analogs of quantum
mechanical angular momentum eigenstates. These distributions are then employed
in four schemes characterized by different types of detectors measuring the
angular momenta. When the model includes an interaction between the detector
and the measured particle leading to ensemble dependencies, the relevant Bell
inequalities are violated if total angular momentum is required to be
conserved. The violation is explained by identifying assumptions made in the
derivation of Bell's theorem that are not fulfilled by the model. These
assumptions will be argued to be too restrictive to see in the violation of the
Bell inequalities a faithful signature of nonlocality.Comment: Extended manuscript. Significant change
The Self Model and the Conception of Biological Identity in Immunology
The self/non-self model, first proposed by F.M. Burnet, has dominated immunology for sixty years now. According to this model, any foreign element will trigger an immune reaction in an organism, whereas endogenous elements will not, in normal circumstances, induce an immune reaction. In this paper we show that the self/non-self model is no longer an appropriate explanation of experimental data in immunology, and that this inadequacy may be rooted in an excessively strong metaphysical conception of biological identity. We suggest that another hypothesis, one based on the notion of continuity, gives a better account of immune phenomena. Finally, we underscore the mapping between this metaphysical deflation from self to continuity in immunology and the philosophical debate between substantialism and empiricism about identity
Immunology at the crossroads
As decades of research have resulted in few clinical applications, it is time to think about new research strategies to understand the workings of the immune syste
- …