Reflections on the NatureCHI workshop series : unobtrusive user experiences with technology in nature

Being in nature is often regarded to be calming, relaxing and purifying. While technology has the potential to support engagement with nature, developing systems that provide support in an unobtrusive manner holds many challenges for interaction design. In this article, the articles describe their reflections around the NatureCHI workshop series. The aim with the workshops has been to help foster a research community interested in the design of Unobtrusive User Experiences with Technology in Nature. The first of two workshops ran as part of CHI 2016 in San Jose, California, while the second workshop took place alongside MobileHCI 2017 in Vienna, Austria. With 25 papers presented in total, the workshops demonstrate a rising interest in the areas where nature and interactive technologies meet.https://www.igi-global.com/journal/international-journal-mobile-human-computer/1126am2018Informatic

HUMAN CYCLOSPORIASIS DIAGNOSIS: REPORT OF A CASE IN SÃO PAULO, SP, BRAZIL

Diagnosis of the human cyclosporiasis is reported in São Paulo, SP, Brasil. Cyclospora cayetanensis has been identified in the feces of a patient by a modified Kinyoun staining method, with later sporulation in a solution of 2.5% potassium dichromate. The probability that this parasite is the eventual cause of gastrointestinal disturbances in the country was stimulated by this finding, which was arrived at by a simple technique. It had been kept in mind that the disease was expressing itself mainly among immunocompromised patients, whose number is increasing; especially in those with acquired immunodeficiency syndrome (AIDS), which is caused by the human immunodeficiency virus (HIV).<br>É relatado o diagnóstico de ciclosporíase humana em São Paulo, SP, Brasil. Cyclospora cayetanensis foi encontrada nas fezes de um indivíduo através de exame pelo método de coloração de Kinyoun modificado, com posterior esporulação em dicromato de potássio a 2,5%. Esta verificação deve estimular a necessidade de considerar a ciclosporíase como eventual causa de distúrbios gastrointestinais no país, podendo ela ser reconhecida até mesmo por meio de técnica razoavelmente simples. Foi ainda lembrado que esta parasitose vem adquirindo expressividade sobretudo pelo fato de não raramente acometer imunodeprimidos, agora cada vez mais numerosos em especial como decorrência da infecção pelo vírus da imunodeficiência humana (HIV), que causa a síndrome da imunodeficiência adquirida (AIDS)

Different Transmembrane Domains Associate with Distinct Endoplasmic Reticulum Components during Membrane Integration of a Polytopic Protein

We have been studying the insertion of the seven transmembrane domain (TM) protein opsin to gain insights into how the multiple TMs of polytopic proteins are integrated at the endoplasmic reticulum (ER). We find that the ER components associated with the first and second TMs of the nascent opsin polypeptide chain are clearly distinct. The first TM (TM1) is adjacent to the α and β subunits of the Sec61 complex, and a novel component, a protein associated with the ER translocon of 10 kDa (PAT-10). The most striking characteristic of PAT-10 is that it remains adjacent to TM1 throughout the biogenesis and membrane integration of the full-length opsin polypeptide. TM2 is also found to be adjacent to Sec61α and Sec61β during its membrane integration. However, TM2 does not form any adducts with PAT-10; rather, a transient association with the TRAM protein is observed. We show that the association of PAT-10 with opsin TM1 does not require the N-glycosylation of the nascent chain and occurs irrespective of the amino acid sequence and transmembrane topology of TM1. We conclude that the precise makeup of the ER membrane insertion site can be distinct for the different transmembrane domains of a polytopic protein. We find that the environment of a particular TM can be influenced by both the “stage” of nascent chain biosynthesis reached, and the TM's relative location within the polypeptide