33 research outputs found
Met het oog op stress
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129288.pdf (publisher's version ) (Open Access)Rede bij Ambtsaanvaarding, 26 juni 2008Radboud Universiteit Nijmegen : [S.n.]11 p
Regulatory elements involved in the developmental control of rat gamma-crystallin promoters
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Analysis of the tumor vasculature and metastatic behavior of xenografts of human melanoma cell lines transfected with vascular permeability factor
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22862___.PDF (publisher's version ) (Open Access
Sp1- and octamer-consensus sequence binding proteins during lens fibre differentiation
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sHSP in the eye lens: crystallin mutations, cataract and proteostasis
Alpha-crystallin, a major component of the eye lens cytoplasm, is a large multimer formed from two members of the small heat shock protein (sHsp) family. Inherited crystallin mutations are a common cause of childhood cataract, whereas miscellaneous changes to the long-lived crystallins cause age-related cataract, the most common cause of blindness worldwide. Newly formed eye lens cells use proteostasis to deal with the consequences of mutations, whereas mature lens cells, devoid of the ATP-driven folding and degradation machines, are hypothesised to have the Ī±-crystallin āholdaseā chaperone function to prevent protein aggregation. We discuss the impact of truncating and missense mutations on Ī±-crystallin, based on recent progress towards determining sHsp 3D structure. Dominant missense mutations to the āĪ±-crystallin domainā of Ī±A- (HSPB4) or Ī±B-crystallin (HSPB5) occur on residues predicted to facilitate domain dynamics. Ī±B-crystallin is also expressed in striated muscle and mutations cause myopathy. The impact on these cellular cytoplasms is compared where sHsp multimer partners and metabolic constraints are different. Selected inherited mutations of the lens Ī²- and Ī³-crystallins are considered in the context of their possible dependence on the āholdaseā chaperone function of Ī±-crystallin. Looking at discrete changes to specific crystallin polypeptide chains that can function as chaperone or substrate provide insights into the workings of a cytoplasmic proteostatic system. These observations provide a framework for validating the function of Ī±-crystallin as a chaperone, or as a lens space filler adapted from a chaperone function. Understanding the mechanistic role of Ī±-crystallins will aid progress in research into age-related cataract and adult-onset myopathy
mRNA made during heat shock enters the first round of translation
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34640.pdf (publisher's version ) (Closed access
The mechanism of recruitment of the lactate dehydrogenase-B/epsilon-crystallin gene by the duck lens
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Vascular permeability factor expression influences tumor angiogenesis in human melanoma lines xenografted to nude mice
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21464___.PDF (publisher's version ) (Open Access
Extralenticular expression of beta-crystallin genes in adult mouse, newborn rat and embryonic Xenopus laevis
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